Shi Zhengli

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Shi Zhengli ( Chinese  石正麗 ; born May 26, 1964 in Xixia (Nanyang) near Nanyang ) is a Chinese virologist who researches SARS- like coronaviruses. Shi heads the Center for Emerging Infectious Diseases at the Institute of Virology Wuhan (English Wuhan Institute of Virology (WIV)) of the Chinese Academy of Sciences (CAS). In 2017, Shi and her colleague Cui Jie discovered that the SARS coronavirus likely originated from a bat population in China's Yunnan Province . Shi became known in the popular press as "Bat Woman" during the 2019-20 coronavirus pandemic for her work on bat coronaviruses. Shi is a member of the Chinese Society of Microbiology's Virology Committee. She is editor of the Board of Virologica Sinica , the Chinese Journal of Virology, and the Journal of Fishery Sciences of China .

Education

In 1987 she graduated from Wuhan University . In 1990 she received her Masters at the Institute of Virology Wuhan of the Chinese Academy of Sciences (CAS) and in 2000 her doctorate at the University of Montpellier in France.

research

In 2005, a team led by Shi Zhengli and Cui Jie discovered that the SARS virus originated from bats. Their results were published in the journal Science in 2005 and in the Journal of General Virology in 2006.

In 2011, researchers from the Wuhan Institute of Virology traveled with US and Australian colleagues in the karst caves of Kunming Jiuxiang Scenic Region , in Yunnan Province in southern China, to collect excrement from horseshoe bats that contain viruses. Their search was successful: In 117 saliva and faeces samples, they discovered 27 previously unknown viruses that were similar to the SARS virus. In 2013 they reported in "Nature" about this discovery and the isolation of a SARS-like virus that uses the protein "spikes" on its corona "crown" for docking with human ACE2 receptors.

In 2014 Shi Zhengli was involved in an investigation into bat coronaviruses, in particular functional tests with SARS and bat coronaviruses, a joint research carried out by the University of North Carolina and the Institute of Virology Wuhan under the direction of Ralph S. Baric.

In October 2014, the Obama cabinet imposed a moratorium on funding research that makes a virus more deadly or contagious. Such research has been called “gain-of-function experiments”. The moratorium is intended to interrupt risky virology studies with influenza, MERS and SARS viruses.

During the coronavirus pandemic 2019-20 , Shi and other scientists from the institute formed an expert group to research SARS-CoV-2 .

In February 2020, researchers under the direction of Shi Zhengli published an article in Nature entitled "A pneumonia outbreak associated with a new coronavirus of probable bat origin", describing the transmission of coronaviruses from bats to pigs; Another article in BioRxiv reported that SARS-CoV2 belongs to the same family as SARS and is closely related to a species found in bats.

In February 2020, her team in Cell Research published an article showing that Remdesivir , an experimental drug from Gilead Sciences , had a positive effect on inhibiting the virus in vitro, and filed a patent for that on behalf of the Wuhan Institute of Virology medicine in China, Shi was co-author of a report in which the virus first Disease X is shown.

In February 2020, the South China Morning Post reported that Shi's decades of work building one of the world's largest databases on bat viruses gave the scientific community a "head start" in understanding the virus. The newspaper also reported that Shi was the focus of personal attacks on Chinese social media that claimed the WIV was the source of the virus. This prompted Shi to post, "I swear with my life, [the virus] has nothing to do with the laboratory," and when Shi was asked by the newspaper to comment on the attacks, it replied, "My time must be spent on more important matters. " Caixin Media Company Ltd reported that Shi had made further public statements against "perceived Tinfoil has theories about the new virus's source" and quoted them as saying, "The novel 2019 coronavirus is nature punishing the human race for keeping uncivilized living habits. I, Shi Zhengli, swear on my life that it has nothing to do with our laboratory "(" The novel coronavirus 2019 is nature that punishes humanity for it, Maintain uncivilized habits. I, Shi Zhengli, swear by my life that it has nothing to do with our laboratory ").

In a March 2020 interview with Scientific American calling her China's "bat woman," Shi said, "Bat-borne coronaviruses will cause more outbreaks," "Bat-borne coronaviruses will cause more outbreaks," and "Us have to find them before they find us. " ("We must find them before they find us.")

In 2015, scientists questioned whether Shi's team was taking unnecessary risks, according to an April 2020 statement by Josh Rogin in The Washington Post . According to Rogin, US officials who visited the Wuhan Institute of Virology in 2018 had sent two wire reports back to Washington in which they "warned of the security and management weaknesses in the Wuhan Institute of Virology laboratory." They also met with Shi Zhengli.

Honors

See also

Web links

Wikiquote: Shi Zhengli  - Quotes

Individual evidence

  1. ↑ a b David Cyranoski: Bat cave solves mystery of deadly SARS virus - and suggests new outbreak could occur , Nature. December 1, 2017. Accessed April 20, 2020. 
  2. ↑ a b How China's "Bat Woman" Hunted Down Viruses from SARS to the New Coronavirus . March 11, 2020.
  3. ^ Archived copy (zh) . In: sciencenet.cn , March 10, 2009. Retrieved February 6, 2019. 
  4. ↑ Li Wendong, Zhengli Shi, Meng Yu, Wuze Ren, Craig Smith, Jonathan H Epstein, Hanzhong Wang, Gary Crameri, Zhihong Hu, Huajun Zhang, Jianhong Zhang, Jennifer McEachern, Hume Field, Peter Daszak, Bryan T Eaton, Shuyi Zhang , Lin-Fa Wang: Bats Are Natural Reservoirs of SARS-Like Coronaviruses . In: Science . 310, No. 5748, October 2005, pp. 676-679. bibcode : 2005Sci ... 310..676L . doi : 10.1126 / science.1118391 . PMID 16195424 .
  5. ^ Wei ( 鲁 伟 ) Lu, Liu Zheng ( 刘铮 ): Archived copy (zh) . In: sciencenet.cn , March 10, 2009. Retrieved January 26, 2020. 
  6. ↑ Wuze Ren, Wendong Li, Meng Yu, Pei Hao, Yuan Zhang, Peng Zhou, Shuyi Zhang, Guoping Zhao, Yang Zhong, Shengyue Wang, Lin-Fa Wang, Zhengli Shi: Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis . In: J Gen Virol . 87, No. 11, November 1, 2006, pp. 3355-3359. doi : 10.1099 / vir.0.82220-0 . PMID 17030870 .
  7. ↑ Yang, Yang: Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus . In: Journal of Virology . 89, No. 17, June 10, 2015, pp. 9119-9123. doi : 10.1128 / JVI.01279-15 . Retrieved April 14, 2020.
  8. ↑ Vineet D. Menachery, Boyd L. Yount, Kari Debbink, Sudhakar Agnihothram, Lisa E. Gralinski, Jessica A. Plante, Rachel L. Graham, Trevor Scobey, Xing-Yi Ge, Eric F. Donaldson, Scott H. Randell: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence . In: Nature Medicine . 21, No. 12, November 11, 2015, ISSN  1546-170X , pp. 1508-1513. doi : 10.1038 / nm.3985 . PMID 26552008 . PMC 4797993 (free full text). ; Ralph S. Baric, [1] , [2]
  9. ↑ In October 2014, the US government had imposed a moratorium on funding of any research that makes a virus more deadly or contagious, known as “gain-of-function” experiments. see: State Department cables warned of safety issues at Wuhan lab studying bat coronaviruses. in The Washington Post , April 14, 2020; The PREDICT project seeks to identify new emerging infectious diseases that could become a threat to human health. PREDICT partners locate their research in geographic "hotspots" and focus on wildlife that are most likely to carry zoonotic diseases - animals such as bats, rodents, and nonhuman primates. "USAID-EPT-PREDICT" ("EcoHealthAlliance"); [3]
  10. ^ Jocelyn Kaiser: Letters from NIH and NIAID telling 14 institutions to halt projects . November 13, 2014.
  11. ↑ Jocelyn Kaiser: Moratorium on risky virology studies leaves work at 14 institutions in limbo ( en ) November 17, 2014.
  12. ↑ Juan ( 张 隽 ) Zhang, Guan Xiyan ( 关 喜 艳 ): zh: 石正丽 等 13 位 专家组 队 攻关 新型 肺炎 研究 (Shi Zhengli and 13 other experts have teamed up to fight new pneumonia) (zh) . In: people.com.cn , January 24, 2020. Retrieved January 26, 2020. 
  13. ^ Jon Cohen, Mining coronavirus genomes for clues to the outbreak's origins . February 1, 2020. Retrieved on February 4, 2020: "team led by Shi Zheng-Li, a coronavirus specialist at the Wuhan Institute of Virology, reported on January 23 on bioRxiv that 2019-nCoV's sequence was 96.2% similar to a bat virus and had 79.5% similarity to the coronavirus that causes severe acute respiratory syndrome (SARS), a disease whose initial outbreak was also in China more than 15 years ago. "
  14. ↑ Zhengli Shi, Team of 29 researchers at the WIV: A pneumonia outbreak associated with a new coronavirus of probable bat origin . In: Nature . 579, No. 7798, February 2020, pp. 270-273. doi : 10.1038 / s41586-020-2012-7 . PMID 32015507 .
  15. ↑ The world is now distancing itself from China. RND April 23, 2020.
  16. ↑ Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa- Xian Zhan, Yan-Yi Wang, Geng-Fu Xiao, Zheng-Li Shi: Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin . In: bioRxiv . January 23, 2020, p. 2020.01.22.914952. doi : 10.1101 / 2020.01.22.914952 . Retrieved January 26, 2020.
  17. ↑ Regalado Antonio: Virus in Chinese outbreak is closest to one from bats, not snakes . In: technologyreview . Retrieved January 26, 2020. 
  18. ↑ Zhengli Shi, Team of 10 researchers at the WIV: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro . In: Cell Research . 30, No. 3, February 4, 2020, pp. 269-271. doi : 10.1038 / s41422-020-0282-0 . PMID 32020029 . PMC 7054408 (free full text).
  19. ↑ China Wants to Patent Gilead's Experimental Coronavirus Drug . Retrieved February 5, 2020.
  20. ↑ Denise Grady: China Begins Testing an Antiviral Drug in Coronavirus Patients . In: New York Times , February 6, 2020. Retrieved February 8, 2020. 
  21. ↑ Zhengli Shi, Jiang Shibo: The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus. . In: Virologica Sinica . 2020. doi : 10.1007 / s12250-020-00206-5 . PMID 32060789 .
  22. ↑ a b Stephen Chen: Coronavirus: bat scientist's cave exploits offer hope to beat virus 'sneakier than Sars' . In: South China Morning Post , February 6, 2020. Retrieved February 8, 2020. 
  23. ^ Wuhan Virology Lab Deputy Director Again Slams Coronavirus Conspiracies . February 7, 2020. Accessed February 8, 2020.
  24. ↑ Person of the Week: Zheng-Li Shi Is China Afraid of the Truth? , Wolfram Weimer, April 14, 2020, [4] ; [5]
  25. ↑ John Rogin : State Department cables warned of safety issues at Wuhan lab studying bat coronaviruses . In: Washington Post , April 14, 2020. 
  26. ↑ zh: 法国 驻华 大使 亲临 武汉 病毒 所 为 袁志明 、 石正丽 研究员 授勋 ( zh ) Wuhan Institute of Virology. 20th June 2016.
  27. ↑ zh: 新型 冠状 病毒 可能 来源于 蝙蝠！ “蝙蝠 女侠” 石正丽 发现 其 与 蝙蝠 冠状 病毒 同源 性 为 96% (The new coronavirus can come from bats! "Batwoman" Shi Zhengli found out that its homology with the bat coronavirus is) (zh) . In: sina , January 24, 2020. Retrieved January 26, 2020. 
  28. ↑ zh: 学界 大 牛！ 12 位 华人 学者 当选 2019 年 美国 微生物 科学院 院士 (Academic Daniel! 12 Chinese scientists elected to the American Academy of Microbiology in 2019) (zh) . In: xincailiao.com , February 3, 2019. Retrieved February 6, 2019. 


Note: This article places the family name before the person's first name. This is the usual order in Chinese. Shi is the family name here, Zhengli is the first name.
personal data
SURNAME Shi, Zhengli
BRIEF DESCRIPTION Chinese virologist (Institute of Virology Wuhan)
DATE OF BIRTH May 26, 1964
PLACE OF BIRTH Xixia (Nanyang) near Nanyang