Terazosin
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Non-proprietary name | Terazosin | |||||||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Terazosin is a drug from the group of alpha blockers that is used to treat clinical symptoms and urination disorders in benign prostatic hyperplasia (BPH) and - as a reserve drug - to treat arterial hypertension . Terazosin was patented by Abbott ( trade name Hytrin ® ) in 1977 and is commercially available as a generic .
Together with doxazosin and indoramine, it belongs to the prazosin derivatives, but in contrast to prazosin it has a higher bioavailability (90%) and a longer half-life (10-18 hours).
Via competitive antagonism at the postsynaptic α 1 -adrenoceptor , it inhibits the action of noradrenaline and thus has a sympatholytic effect. The increased binding of norepinephrine to the presynaptic α 2 -adrenoceptors also leads to an increased effect. The lowering of blood pressure achieved in this way (with lowering of pre- and afterload) is used in the therapy of arterial hypertension .
Trade names
- Monopreparations : Flotrin (D), Heitrin (D), Hytrin (CH), Tera TAD (D), Terablock (D), Teranar (D), Terazid (D), Urocard (A), Uroflo (A), Urozosin ( D), Vicard (A)
Individual evidence
- ↑ a b entry on terazosin. In: Römpp Online . Georg Thieme Verlag, accessed on November 10, 2014.
- ↑ a b c d J. Bauer, J. Morley, S. Spanton, FJJ Leusen, R. Henry, S. Hollis, W. Heitmann, A. Mannino, J. Quick, W. Dziki: Identification, preparation, and characterization of several polymorphs and solvates of terazosin hydrochloride. In: Journal of Pharmaceutical Sciences. 95, 2006, pp. 917-928, doi: 10.1002 / jps.20425 .
- ↑ a b Datasheet Terazosin hydrochloride from Sigma-Aldrich , accessed on April 23, 2011 ( PDF ).
- ^ A b The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. 14th Edition, Merck & Co., Inc., Whitehouse Station, NJ, USA 2006, ISBN 978-0-911910-00-1 , p. 1574.
- ↑ Roehrborn CG: Efficacy of alpha-Adrenergic Receptor Blockers in the Treatment of Male lower urinary tract symptoms . In: Reviews in Urology . 11, No. Suppl 1, 2009, pp. S1-8. PMID 20126606 . PMC 2812889 (free full text).
- ↑ Lepor H: Alpha blockers for the treatment of benign prostatic hyperplasia . In: Reviews in Urology . 9, No. 4, 2007, pp. 181-190. PMID 18231614 . PMC 2213889 (free full text).