Walter Doerfler

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Walter Doerfler (born August 11, 1933 in Weißenburg / Bavaria ) works as a geneticist and virologist in Germany .

Life

education

Walter Doerfler studied medicine in Munich, Erlangen and Hamburg. After that he was intern at Mercer Hospital Trenton , NJ , USA . He held postdoctoral degrees from 1961 to 1963 at the Max Planck Institute for Biochemistry in Munich and from 1963 to 1966 at the Department of Biochemistry, Stanford University Medical School.

Teaching

Walter Doerfler was Assistant Professor from 1966 to 1969 and then Associate Professor from 1969 to 1971. He then held the position of Adjunct Professor at Rockefeller University in New York City between 1971 and 1978 . From 1972 to 2002 Doerfler was a professor at the Institute for Genetics at the University of Cologne . Since 2002 he has been professor emeritus activ at the University of Cologne.

Visiting professorships

In 1971 and 1972 Walter Doerfler was a visiting professor at Uppsala Universitet . In 1978 he was appointed to a visiting professorship at Stanford University . In 1983 this call was repeated. In 1986 and 1999 Princeton University appointed him a visiting professor. The Vanderbilt University called Walter Doerfler after his retirement in of 2006.

Since 2002 he has been teaching at the Institute for Virology at the Friedrich-Alexander University Erlangen-Nuremberg .

Scientific contributions and discoveries

In the course of his academic work, Walter Doerfler published over four hundred articles and fourteen books in his field.

During his scientific work he made the following genetic discoveries:

  • Molecular Biology of Oncogenic Adenovirus Type 12
  • Integration of viral DNA into the genome of mammalian cells
  • de novo methylation of integrated foreign DNA
  • Promoter methylation as a long-term switch-off signal for genes
  • Integration of foreign DNA has remote effects on methylation in the genome of the recipient cell
  • Fate of foreign DNA ingested with food
  • Patterns of methylation in the human genome, molecular medical genetics

Prizes and awards

ancestors

Walter Doerfler's ancestors are Hans Doerfler (1863–1942), a pioneer in surgery in Bavaria, and Franz Jakob Kreuter (1813–1889), a civil engineer and architect in Vienna (Munich).

literature

  • W. Doerfler: The fate of the DNA of adenovirus type 12 in baby hamster kidney cells . In: Proc. Natl. Acad. Sci. tape 60 . USA 1968, p. 636-643 .
  • J. Groneberg, Y. Chardonnet and W. Doerfler: Integrated viral sequences in adenovirus type 12-transformed hamster cells . In: Cell . tape 10 , 1977, pp. 101-111 .
  • W. Doerfler: DNA methylation and gene activity . In: Ann. Rev. Biochem. tape 52 , 1983, pp. 93-124 .
  • H. Heller, C. Kämmer, P. Wilgenbus and W. Doerfler: Chromosomal insertion of foreign (adenovirus type 12, plasmid, or bacteriophage 1) DNA is associated with enhanced methylation of cellular DNA segments . In: Proc. Natl. Acad. Sci . tape 92 . USA 1995, p. 5515-5519 .
  • W. Doerfler: In pursuit of the first recognized epigenetic signal . DNA methylation. In: Epigenetics . tape 3 , 2008, p. 125-133 .

Web links

Individual evidence

  1. ^ Institute of Genetics, University of Cologne and Institute for Clinical and Molecular Virology, Erlangen University Medical School (ed.): Laboratory for Molecular Virology and Medical Genetics 2009 . Institute of Genetics, University of Cologne and Institute for Clinical and Molecular Virology, Erlangen University Medical School. 2009, The Research Group, p. 1 ( online [PDF; 770 kB ; accessed on November 7, 2009]).
  2. Member entry by Prof. Dr. Walter Doerfler (with picture) at the German Academy of Sciences Leopoldina , accessed on July 4, 2016.