Werner Hunstein

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Werner Hunstein (born August 8, 1928 in Kassel ; † February 16, 2012 in Heidelberg ) was a German physician .

Life

Werner Hunstein passed the Abitur examination in 1947. He studied medicine in Freiburg im Breisgau and completed it with a dissertation on lymphogranulomatosis with Ludwig Heilmeyer .

In 1972 Hunstein was appointed to the Medical Polyclinic in Heidelberg . He built up and headed the department of hematology , oncology and rheumatology . The first autologous transplantation of blood stem cells by M. Körbling was successfully carried out at the department in 1985 . He retired in 1996.

Amyloidosis disease

Hunstein fell seriously ill in 2001. He went to various doctors for treatment. In December 2004 amyloidosis was diagnosed, more precisely systemic light chain (AL) amyloidosis as one of 20 known forms of amyloidosis. In the spring of 2005 he was treated with chemotherapy to prevent further thickening of the heart septum . The disease was considered incurable, and Hunstein had ceased therapy in August 2006.

Green tea therapy

Two former senior physicians at Hunstein, Antonio Pezzutto and Bernd Dörken , reported to Hunstein that the molecular medicine specialist Erich Wanker at the Max Delbrück Center for Molecular Medicine , Berlin, had discovered that an ingredient in green tea, epigallocatechin gallate (EGCG), prevents amyloid deposits and even dissolve it, and recommended that he consume green tea . Hunstein then drank two liters of green tea a day. His health improved noticeably, and despite concerns about not being taken seriously by his colleagues, he decided in 2007 to publish it in the medical journal Blood . His report, published in September 2007, received a lot of media coverage. A study for the treatment of transthyretin amyloidosis, for which there is currently no chemotherapy, has been carried out at the Medical Clinic of Heidelberg University.

Werner Hunstein has published together with other scientists about the new therapy option. In November 2009, Hunstein had to temporarily stop taking tea extracts because of peritonitis and prostate surgery. In addition, the dialysis had lowered the EGCG level. The amyloidosis symptoms then increased. It was possible to control the relapse again.

The effectiveness of the therapeutic approach has now been proven. Derliz Mereles and other scientists continue to research.

literature

  • Who's who in Germany: a biographical encyclopedia containing some 23,000 biographies of prominent personalities in Germany and a listing of 2,400 organizations. Issue 6, 1976.

Web links

Individual evidence

  1. ↑ Biographical. hunstein-egcg.de
  2. ↑ a b Johannes Gruber: The secret of green tea. ( drhuber.at ( Memento of the original from June 29, 2010 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. ) @1@ 2Template: Webachiv / IABot / www.drhuber.at
  3. ↑ a b Ingeborg Bördlein: Self- experiment on the threshold of death . In: Hamburger Morgenpost , June 10, 2008
  4. ^ A b Frank Grossmann: Neglected diseases: Interview with Professor Werner Hunstein - "Green tea for my heart" In: Winterthurer Stadtanzeiger . June 7, 2010
  5. ↑ Marion Rollin : The miraculous rescue of Professor Hunstein. In: Spiegel Online . February 22, 2009
  6. ↑ Werner Hunstein: Epigallocathechin-3-gallate in AL amyloidosis: a new therapeutic option? In: Blood . September 15, 2007, Vol. 110, No. 6, p. 2216
  7. ↑ Does green tea help against pathological protein deposits? In: Neue Zürcher Zeitung . September 19, 2007
  8. ↑ Effects of green tea consumption on the clinical course of transthyretin amyloidosis . (PDF; 14 kB) Study at the Medical Clinic of Heidelberg University.
  9. ↑ D. Mereles, SJ Buss, SE Hardt, W. Hunstein, HA Katus: Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis. In: Clinical Research in Cardiology 2010 Mar 10 PMID 20221615
  10. ↑ Werner Hunstein: Recurrence of AL-Amyloidosis: Peritoneal Dialysis Reduces EGCG Plasma Level.  ( Page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. (PDF) June 2010@1@ 2Template: Toter Link / www.hunstein-egcg.de  
  11. ↑ J. Bieschke, J. Russ, RP Friedrich et al .: EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. In: Proc Natl Acad Sci USA. 2010, 107 (17), pp. 7710-7715.
  12. ↑ Derliz Mereles, Werner Hunstein: Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises? In: Int. J. Mol. Sci. 2011, 12 (9), pp. 5592-5603; doi: 10.3390 / ijms12095592
personal data
SURNAME Hunstein, Werner
BRIEF DESCRIPTION German medic
DATE OF BIRTH August 8, 1928
PLACE OF BIRTH kassel
DATE OF DEATH February 16, 2012
Place of death Heidelberg