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<!-- Quit adding speculative maps of 2008 swing states. Use swing states from 2004.-->
[[Image:Succinate Dehygrogenase 1YQ3 Haem group.png|thumb|right|220px|The bound [[heme]] cofactor of [[succinate dehydrogenase]], an [[enzyme]] in the [[mitochondria]]l [[electron transfer chain]]. The large semi-transparent sphere indicates the location of the [[iron]] [[ion]].]]
{{Original research|date=May 2008}}
A '''cofactor''' is a non-protein [[chemical compound]] that is bound (either tightly or loosely) to an [[enzyme]] and is required for [[catalysis]].<ref>{{cite web |url=http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#34 |title=Glossary of Terms Used in Bioinorganic Chemistry: Cofactors |accessdate=2007-10-30 |last=de Bolster |first=M.W.G. |date=1997 |publisher=International Union of Pure and Applied Chemistry}}</ref> They can be considered "helper molecules/ions" that assist in biochemical transformations. Certain substances such as [[water]] and various abundant ions may be bound tightly by enzymes, but are not considered to be cofactors since they are ubiquitous and rarely limiting. Some sources limit the use of the term "cofactor" to inorganic substances.<ref>{{cite web |url=http://academic.brooklyn.cuny.edu/biology/bio4fv/page/coenzy_.htm |title=coenzymes and cofactors |accessdate=2007-11-17 |format= |work=}}</ref><ref>{{cite web |url=http://www.elmhurst.edu/~chm/vchembook/571cofactor.html |title=Enzyme Cofactors |accessdate=2007-11-17 |format= |work=}}</ref>
{{for|the film of the same name|Swing State (film)}}
[[Image:Swing states, 2004.svg|thumb|300px|2004 swing states. States where the margin of victory was less than 5% are colored red if Bush won and blue if Kerry won.]]
A '''swing state''' (also, '''battleground state''' or '''purple state''') in [[United States]] [[President of the United States|presidential]] [[Politics of the United States|politics]] is a [[U.S. state|state]] in which no candidate has overwhelming support, meaning that any of the major candidates have a reasonable chance of winning the state's [[U.S. Electoral College|electoral college]] votes. Such states are targets of both major [[List of political parties in the United States|political parties]] in [[U.S. presidential election|presidential elections]], since winning these states is the best opportunity for a party to gain electoral votes. Non-swing states are sometimes called '''safe states''', because one candidate has strong enough support that they can safely assume they will win the state's votes.


==Origin of swing states==
Cofactors can be divided into two broad groups: [[coenzyme]]s and [[prosthetic group]]s. Coenzymes are small [[organic compound|organic]] non-[[protein]] [[molecule]]s that carry chemical groups between [[enzyme]]s. These molecules are not bound tightly by enzymes and are released as a normal part of the catalytic cycle. In contrast, [[prosthetic group]]s form a permanent part of the protein structure.
[[Image:Bush Kerry 2004.jpg|250px|right|thumb|Heavy television advertising by candidates in a swing state can bring out supporters for the candidates more than in other states. These yard signs in a residential district of [[Grosse Pointe, Michigan]] during the [[U.S. Presidential election, 2004|2004 Presidential election]] show the difference in opinions between two neighbors.]]
[[Image:2004CampaignAttention.png|right|thumb|450px|These maps show the amount of attention given in the 2004 election by [[George W. Bush|Bush]] and [[John Kerry|Kerry]] campaigns during the final five weeks of the election. At left, each waving hand represents a visit from a presidential or vice-presidential candidate during the final five weeks. At right, each dollar sign represents one million dollars spent on TV advertising by the campaigns during the same time period.]]


In US Presidential elections, the [[U.S. Electoral College]] system allows each state to decide the method by which it awards electors. Since legislatures want to increase the voting power of the majority of their states, all states except [[Maine]] and [[Nebraska]] (explained below) use a [[Plurality voting system|winner-take-all]] system, where the candidate who wins the most popular votes in a state wins all of that state's electoral votes. Under this system no advantage is gained by winning more than a plurality of the vote, nor is there any advantage gained by winning additional votes in a state that will still be lost. In other words, Presidential candidates have no incentive to spend time or resources in states they are likely to win or lose by a sizeable margin.
==Apoenzymes and holoenzymes==
An [[enzyme]] without a cofactor is referred to as an apoenzyme, and the completely active enzyme (in addition to the cofactor) is called a holoenzyme.An enzyme that catalyzes gay sex is known as buttfuckase


Since a national campaign is interested in electoral votes, rather than the national popular vote, it tends to ignore states that it believes it will win easily; since it will win these without significant campaigning, any effort put into them is essentially wasted. A similar logic dictates that the campaign avoid putting any effort into states that it knows it will lose.
[[Apoenzyme]] + cofactor <=> [[Holoenzyme]]


For instance, a [[Republican Party (United States)|Republican]] candidate (the more [[Conservatism in the United States|conservative]] of the two major parties) can easily expect to win many of the [[Deep South|Southern]] states like [[Mississippi]], [[Alabama]] and [[South Carolina]], which historically have a very conservative culture and a more recent history of voting for Republican candidates. Similarly, the same candidate can expect to lose [[California]], [[Vermont]], [[Hawaii]], [[Connecticut]], [[Rhode Island]], and [[New York]], traditionally [[American liberalism|liberal]] states, no matter how much campaigning is done in those states. The only states which the campaign would target to spend time, money, and energy in are those that could be won by either candidate. These are the swing states.
==Metal ion cofactors==
{{further|[[Metalloprotein]]s}}
[[Metal]] [[ion]]s are common cofactors. The study of these cofactors falls under the area of [[bioinorganic chemistry]]. In [[nutrition]], the list of essential [[trace element]]s reflects their role as cofactors. In humans this list commonly includes [[iron]], [[manganese]], [[cobalt]], [[copper]], [[zinc]], [[selenium]], and [[molybdenum]].<ref>{{cite journal |author=Aggett PJ |title=Physiology and metabolism of essential trace elements: an outline |journal=Clin Endocrinol Metab |volume=14 |issue=3 |pages=513–43 |year=1985 |pmid=3905079 |doi=10.1016/S0300-595X(85)80005-0}}</ref> Although [[chromium]] deficiency causes [[impaired glucose tolerance]], no human enzyme that uses this metal as a cofactor has been identified.<ref>{{cite journal |author=Stearns DM |title=Is chromium a trace essential metal? |journal=Biofactors |volume=11 |issue=3 |pages=149–62 |year=2000 |pmid=10875302}}</ref><ref>{{cite journal |author=Vincent JB |title=The biochemistry of chromium |journal=J. Nutr. |volume=130 |issue=4 |pages=715–8 |year=2000 |pmid=10736319 |url=http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=10736319}}</ref> [[Iodine]] is also an essential trace element, but this element is used as part of the structure of [[thyroid hormone]]s rather than as an enzyme cofactor.<ref>{{cite journal |author=Cavalieri RR |title=Iodine metabolism and thyroid physiology: current concepts |journal=Thyroid |volume=7 |issue=2 |pages=177–81 |year=1997 |pmid=9133680}}</ref> [[Calcium]] is another special case, in that it is required as a component of the human diet, and it is needed for the full activity of many enzymes: such as [[nitric oxide synthase]], [[phosphatase|protein phosphatases]] or [[adenylate kinase]], but calcium activates these enzymes in [[allosteric regulation]], often binding to these enzymes in a complex with [[calmodulin]].<ref>{{cite journal |author=Clapham DE |title=Calcium signaling |journal=Cell |volume=131 |issue=6 |pages=1047–58 |year=2007 |pmid=18083096 |doi=10.1016/j.cell.2007.11.028}}</ref> Calcium is therefore a [[cell signaling]] molecule, and not usually considered as a cofactor of the enzymes it regulates.<ref>{{cite journal |author=Niki I, Yokokura H, Sudo T, Kato M, Hidaka H |title=Ca2+ signaling and intracellular Ca2+ binding proteins |journal=J. Biochem. |volume=120 |issue=4 |pages=685–98 |year=1996 |pmid=8947828}}</ref>


In Maine and Nebraska, two electoral votes go to the person who wins a plurality in the state, and a candidate gets one additional electoral vote for each [[Congressional District]] in which they receive a plurality. Both of these states have relatively few electoral votes (for the 2004 election, Maine had 4 and Nebraska had 5; the minimum is 3) and are usually not considered swing states (Maine is generally considered a Democratic-leaning state while Nebraska is typically thought to be a Republican state). Despite their different rules, neither has ever had a split electoral vote.
Other organisms require additional metals as enzyme cofactors, such as [[vanadium]] in the [[nitrogenase]] of the [[nitrogen fixation|nitrogen-fixing]] bacteria of the genus ''[[Azotobacter]]'',<ref>{{cite journal |author=Eady RR |title=The vanadium-containing nitrogenase of Azotobacter |journal=Biofactors |volume=1 |issue=2 |pages=111–6 |year=1988 |pmid=3076437}}</ref> [[tungsten]] in the [[aldehyde ferredoxin oxidoreductase]] of the thermophilic [[archaea|archaean]] ''[[Pyrococcus furiosus]]'',<ref>{{cite journal |author=Chan MK, Mukund S, Kletzin A, Adams MW, Rees DC |title=Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase |journal=Science |volume=267 |issue=5203 |pages=1463–9 |year=1995 |pmid=7878465 |doi=10.1126/science.7878465}}</ref> and even [[cadmium]] in the [[carbonic anhydrase]] from the marine [[diatom]] ''Thalassiosira weissflogii''.<ref>{{cite journal |author=Lane TW, Morel FM |title=A biological function for cadmium in marine diatoms |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue=9 |pages=4627–31 |year=2000 |pmid=10781068 |url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10781068 |doi=10.1073/pnas.090091397}}</ref><ref>{{cite journal |author=Lane TW, Saito MA, George GN, Pickering IJ, Prince RC, Morel FM |title=Biochemistry: a cadmium enzyme from a marine diatom |journal=Nature |volume=435 |issue=7038 |pages=42 |year=2005 |pmid=15875011 |doi=10.1038/435042a}}</ref>


In the 2004 [[elections]] [[Colorado]] voted on [[Colorado Amendment 36|Amendment 36]], an initiative which would have allocated the state's electoral votes in proportion to the popular vote in the state. The initiative would have taken effect immediately, applying to the selection of electors in the same election. However, the initiative failed and Colorado remains under the winner-take-all system that is present in 48 states.
In many cases, the cofactor includes both an inorganic and organic component. One diverse set of examples are the [[haem]] proteins, which consists of a [[porphyrin]] ring coordinated to [[iron]].


==Determining swing states==
{|border="1"
The ''[[Oregon Daily Emerald]]'' cited [[University of Oregon]] [[political science]] professor Joel Bloom as mentioning three factors in identifying a swing state: "examining statewide opinion polls, political party registration numbers and the results of previous elections." The article also cites [[Leighton Woodhouse]], co-director of "''Driving Votes,''" as claiming that there is a general consensus among most groups regarding about 75 percent of the states typically thought of as swing states. <ref>"[http://media.www.dailyemerald.com/media/storage/paper859/news/2004/10/04/News/Portrait.Of.A.Swing.State-1969197.shtml Portrait of a swing State]", [[Meghan Cunhiff]], ''[[Oregon Daily Emerald]]'', [[October 4]], [[2004]].</ref>
|-
!Ion!!Examples of enzymes containing this ion
|-
||[[Copper|Cupric]] || [[Cytochrome oxidase]]
|-
||[[Iron|Ferrous or Ferric]] || [[Catalase]]<BR>[[Cytochrome]](via [[Heme]])<BR>[[Nitrogenase]]<BR>[[Hydrogenase]]
|-
||[[Magnesium]] || [[Glucose 6-phosphatase]]<br/>[[Hexokinase]]
|-
||[[Manganese]] || [[Arginase]]
|-
||[[Molybdenum]] || [[Nitrate reductase]]
|-
||[[Nickel]] || [[Urease]]
|-
||[[Selenium]] || [[Glutathione peroxidase]]
|-
||[[Zinc]] || [[Alcohol dehydrogenase]]<br/>[[Carbonic anhydrase]]<br/>[[DNA polymerase]]
|}


==Historical swing states==
==Cofactors and coenzymes==
The swing states of [[Connecticut]], [[Indiana]], [[New Jersey]] and [[New York]] were key to the outcome of the [[United States presidential election, 1888|1888 election]],<ref> "[http://elections.harpweek.com/1888/Overview-1888-4.htm 1888 Overview]" p.4, ''[[Harper's Weekly|HarpWeek]]''.</ref> and [[Illinois]]<ref>"[http://www.nytimes.com/2005/04/21/national/21daley.html Daley Remembered as Last of the Big-City Bosses]", [[David Rosenbaum]], ''[[New York Times]]'', [[April 21]], [[2005]].</ref> and [[Texas]] were key to the outcome of the [[United States presidential election, 1960|1960 election]]. [[Ohio]] has often been considered a swing state,<ref>[http://www.nytimes.com/2004/10/02/arts/02camp.html Trolling the Campuses for Swing-State Votes], Julie Salamon, "[[The New York Times]]", [[October 2]], [[2004]]</ref> <ref>[http://www.slate.com/id/2108640/ Game Theory for Swingers], Jordan Ellenberg, "[[Slate.com]]", [[October 25]], [[2004]]</ref> <ref>[http://www.enquirer.com/editions/2004/07/25/loc_ohconvention25.html Swing-state status lifts Ohio delegates' prestige] Carl Weiser, "[[Cincinnati Enquirer]], [[July 25]], [[2004]]" </ref>, particularly during the [[United States presidential election, 2004|2004 election]], having voted with the winner in every election since 1948 except for 1960,<ref>[http://abcnews.go.com/WN/Vote2008/Story?id=3826822&page=1 As Ohio Goes, So Goes the Nation...Again], Kate Snow, [[ABC World News]], [[November 6]], [[2007]]</ref> and [[Missouri]] has voted for the winner of every presidential election since 1904, save for its support of [[Adlai Stevenson]] in [[United States presidential election, 1956|1956]], prompting the state's reputation as a [[Missouri bellwether|bellwether]].<ref>"[http://archives.cnn.com/2000/ALLPOLITICS/stories/12/13/got.here/index.html How we got here: A timeline of the Florida recount]", [[CNN]], [[December 13]], [[2000]].</ref>
Cofactors vary in their location and the tightness of their binding to the host enzyme. When bound tightly to the enzyme, cofactors are called [[prosthetic group]]s. Loosely-bound cofactors typically associate in a similar fashion to enzyme [[substrate (biochemistry)|substrate]]s. These are better described as [[coenzyme]]s, which are organic substances that directly participate as substrates in an enzyme reaction. [[Vitamin]]s can serve as precursors to coenzymes (e.g. vitamins [[Vitamin B1|B<sub>1</sub>]], [[Vitamin B2|B<sub>2</sub>]], [[Vitamin B6|B<sub>6</sub>]], [[Vitamin B12|B<sub>12</sub>]], [[niacin]], [[folic acid]]) or as coenzymes themselves (e.g. [[vitamin C]]).


==See also==
==Recent swing states==

*[[Enzyme catalysis]]
*'''Florida''': The outcome of 2000 presidential election hung on a margin of 537 votes in this state and the [[United States presidential election, 2000 Florida results|fierce legal battles]] that ensued. Florida's electorate is balanced by heavily Democratic large cities like [[Miami, Florida|Miami]], heavily Republican large cities such as [[Jacksonville]], and sparser, more Republican areas like the [[Florida Panhandle]].
*[[Inorganic chemistry]]
*'''Pennsylvania''': Pennsylvania is famously described by Democratic strategist [[James Carville]] as "you’ve got Philadelphia at one end of the state, Pittsburgh at the other end, and Alabama in the middle.”<ref>"[http://mac10.umc.pitt.edu/u/FMPro?-db=ustory&-lay=a&-format=d.html&storyid=2687&-Find Pitt could see more attempts by legislators to micro-manage]", [[University of Pittsburgh]] [[University Times]], [[October 10]], [[2007]].</ref> Pennsylvania Secretary of the Commonwealth [[Pedro A. Cortés]] stated on [[March 17]], [[2007]], that "The commonwealth’s large number of electoral college votes and diverse population make Pennsylvania a key battleground state." <ref>"[http://www.dos.state.pa.us/dos/lib/dos/press/2007/presidential_primary_03-13-07.pdf Rendell Administration Supports Giving Pennsylvanians a Voice in Presidential Primary]", Commonwealth of [[Pennsylvania]] [[Department of State]], [[March 13]], [[2007]].</ref>
*'''Ohio''': "I think 2008 is very likely to be a hotly contested race in Ohio," stated [[Eric Rademacher]], director of the [[University of Cincinnati]]'s Ohio Poll, for the ''[[Cincinnati Enquirer]]''. <ref>[http://www.enquirer.com/editions/2004/11/04/loc_oh2008.html Intense 2008 election forecast for Ohio]</ref> Its 20 electoral votes were critical to President Bush's reelection in 2004.

== Other terms for ''swing state'' ==
*'''Battleground state'''
*'''Purple state''', so named because [[purple]] is the combination of the colors [[red]] and [[blue]], which are used to represent [[Republican Party (United States)|Republican]]- and [[Democratic Party (United States)|Democratic]]-majority states, respectively. See [[Red states and blue states]].

== See also ==
* [[Red state vs. blue state divide]]
* [[Marginal seat]] in other countries' elections
* [[List of U.S. swing states]]
* [[Missouri bellwether]]
* [[Swing Vote (2008 film)]]


==References==
==References==
{{reflist}}
{{reflist}}


==External links==
== External links ==
* [http://www.swingstatethemovie.com Swing State Ohio Documentary]
* {{eMedicineDictionary|Cofactor}}
* [http://www.inthezoneproductions.net Swing State feature documentary project]
* {{MeshName|Enzyme+cofactors}}
* [http://www.cccarto.com/congress_maps/index.html 2004 clickable Swing State Maps showing county data and results]
* [http://www.cnn.com/interactive/allpolitics/0010/battleground.states/battlegroundstates.html Coverage of battleground states in 2000 election] from [[Cable News Network|CNN]]
* [http://slate.msn.com/id/2101779/ Guide to the 2004 swing states] from ''[[Slate (magazine)|Slate]]''
* [http://www.gwu.edu/~action/2004/battleground04.html Battleground states] from ''Democracy in Action'' site hosted by [[George Washington University]]
* [http://www.interventionmag.com/cms/modules.php?op=modload&name=News&file=article&sid=578 The Swing States] from ''Intervention Magazine''
* [http://www.swingstateproject.com/ Swing State Project], a law student's [[weblog]]
* [http://www.swingstatevoices.com Swing State Voices, a Website for discussion between citizens of the key 2008 battleground states]
* [http://presidentalelections.blogspot.com/ Uwe-Jürgen Ness et al - Conclusion of All Polls in Each State since January 2008, Forecasts on the Base of all Polls, Definitions of Criterias regarding "Swing States", Discussion of Scientific Methods regarding Polls]
* [http://www.fabmac.com/FMA-2004-07-08-Undecideds.pdf The Bush campaign memo detailing its look at the swing states (PDF file)]
* [http://www.msu.edu/~sheppa28/elections.html#states How close were Presidential Elections? Influential States] - Michael Sheppard, Michigan State University
* [http://www.americanfeud.org/ American Feud: A History of Conservatives and Liberals], a documentary film about the history of both movements


[[Category:United States presidential elections]]
{{Enzymes}}
[[Category:American political terms]]
{{Enzyme cofactors}}
[[Category:Enzymes]]
[[Category:Cofactors]]


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Revision as of 03:13, 14 October 2008

2004 swing states. States where the margin of victory was less than 5% are colored red if Bush won and blue if Kerry won.

A swing state (also, battleground state or purple state) in United States presidential politics is a state in which no candidate has overwhelming support, meaning that any of the major candidates have a reasonable chance of winning the state's electoral college votes. Such states are targets of both major political parties in presidential elections, since winning these states is the best opportunity for a party to gain electoral votes. Non-swing states are sometimes called safe states, because one candidate has strong enough support that they can safely assume they will win the state's votes.

Origin of swing states

Heavy television advertising by candidates in a swing state can bring out supporters for the candidates more than in other states. These yard signs in a residential district of Grosse Pointe, Michigan during the 2004 Presidential election show the difference in opinions between two neighbors.
These maps show the amount of attention given in the 2004 election by Bush and Kerry campaigns during the final five weeks of the election. At left, each waving hand represents a visit from a presidential or vice-presidential candidate during the final five weeks. At right, each dollar sign represents one million dollars spent on TV advertising by the campaigns during the same time period.

In US Presidential elections, the U.S. Electoral College system allows each state to decide the method by which it awards electors. Since legislatures want to increase the voting power of the majority of their states, all states except Maine and Nebraska (explained below) use a winner-take-all system, where the candidate who wins the most popular votes in a state wins all of that state's electoral votes. Under this system no advantage is gained by winning more than a plurality of the vote, nor is there any advantage gained by winning additional votes in a state that will still be lost. In other words, Presidential candidates have no incentive to spend time or resources in states they are likely to win or lose by a sizeable margin.

Since a national campaign is interested in electoral votes, rather than the national popular vote, it tends to ignore states that it believes it will win easily; since it will win these without significant campaigning, any effort put into them is essentially wasted. A similar logic dictates that the campaign avoid putting any effort into states that it knows it will lose.

For instance, a Republican candidate (the more conservative of the two major parties) can easily expect to win many of the Southern states like Mississippi, Alabama and South Carolina, which historically have a very conservative culture and a more recent history of voting for Republican candidates. Similarly, the same candidate can expect to lose California, Vermont, Hawaii, Connecticut, Rhode Island, and New York, traditionally liberal states, no matter how much campaigning is done in those states. The only states which the campaign would target to spend time, money, and energy in are those that could be won by either candidate. These are the swing states.

In Maine and Nebraska, two electoral votes go to the person who wins a plurality in the state, and a candidate gets one additional electoral vote for each Congressional District in which they receive a plurality. Both of these states have relatively few electoral votes (for the 2004 election, Maine had 4 and Nebraska had 5; the minimum is 3) and are usually not considered swing states (Maine is generally considered a Democratic-leaning state while Nebraska is typically thought to be a Republican state). Despite their different rules, neither has ever had a split electoral vote.

In the 2004 elections Colorado voted on Amendment 36, an initiative which would have allocated the state's electoral votes in proportion to the popular vote in the state. The initiative would have taken effect immediately, applying to the selection of electors in the same election. However, the initiative failed and Colorado remains under the winner-take-all system that is present in 48 states.

Determining swing states

The Oregon Daily Emerald cited University of Oregon political science professor Joel Bloom as mentioning three factors in identifying a swing state: "examining statewide opinion polls, political party registration numbers and the results of previous elections." The article also cites Leighton Woodhouse, co-director of "Driving Votes," as claiming that there is a general consensus among most groups regarding about 75 percent of the states typically thought of as swing states. [1]

Historical swing states

The swing states of Connecticut, Indiana, New Jersey and New York were key to the outcome of the 1888 election,[2] and Illinois[3] and Texas were key to the outcome of the 1960 election. Ohio has often been considered a swing state,[4] [5] [6], particularly during the 2004 election, having voted with the winner in every election since 1948 except for 1960,[7] and Missouri has voted for the winner of every presidential election since 1904, save for its support of Adlai Stevenson in 1956, prompting the state's reputation as a bellwether.[8]

Recent swing states

  • Florida: The outcome of 2000 presidential election hung on a margin of 537 votes in this state and the fierce legal battles that ensued. Florida's electorate is balanced by heavily Democratic large cities like Miami, heavily Republican large cities such as Jacksonville, and sparser, more Republican areas like the Florida Panhandle.
  • Pennsylvania: Pennsylvania is famously described by Democratic strategist James Carville as "you’ve got Philadelphia at one end of the state, Pittsburgh at the other end, and Alabama in the middle.”[9] Pennsylvania Secretary of the Commonwealth Pedro A. Cortés stated on March 17, 2007, that "The commonwealth’s large number of electoral college votes and diverse population make Pennsylvania a key battleground state." [10]
  • Ohio: "I think 2008 is very likely to be a hotly contested race in Ohio," stated Eric Rademacher, director of the University of Cincinnati's Ohio Poll, for the Cincinnati Enquirer. [11] Its 20 electoral votes were critical to President Bush's reelection in 2004.

Other terms for swing state

See also

References

External links