Allan C. Spradling

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Allan Charles Spradling (* 1949 in Kalamazoo , Michigan ) is an American embryologist and geneticist at the Carnegie Institution for Science in Baltimore , Maryland .

Spradling first studied math and physics and earned a bachelor's degree in physics from the University of Chicago before turning to biology . In 1975 he earned a Ph.D. from the Massachusetts Institute of Technology (MIT). with a work on polytene chromosomes and heat shock proteins in Drosophila . He worked as a postdoctoral fellow at Indiana University in Bloomington .

In 1980 Spradling went to the Carnegie Institution in Baltimore , Maryland , where he became director of the local embryology facility in 1994 . Spradling has also been doing research for the Howard Hughes Medical Institute (HHMI) since 1988 . He is also an adjunct professor of biology at Johns Hopkins University and one of genetics at the Johns Hopkins University School of Medicine , both also in Baltimore.

Bloomington Spradling could prove the first time that protein - coding genes of amplification may be subject. At the Carnegie Institution in 1982, together with Gerry Rubin, he developed a method (coupling to a transposon ) to insert DNA into the genome of Drosophila . As a result, he was able to identify cis elements that are involved in the regulation and amplification of genes. Also with Rubin, Spradling founded the Drosophila genome project in 1991 , which was completed in 2000 with the sequencing of the entire genome. Spradling examined stem cells in their normal tissue environment and described for the first time that stem cells look for a “niche” for themselves, a microenvironment that they need for self-preservation and their intended function.

Spradling's recent work deals with epithelial stem cells and the development of egg cells .

Awards (selection)

Web links

Individual evidence

  1. ^ The Passano Award 1945-2011 at the Passano Foundation (passanofoundation.org); Retrieved April 11, 2012
  2. ^ NAS Award in Molecular Biology. In: nasonline.org. Retrieved January 13, 2016 .
  3. ↑ a b Past GSA Award Recipients at the Genetics Society of America (genetics-gsa.org); Retrieved April 11, 2012
  4. ↑ Book of Members 1780 – present (PDF, 443 kB) of the American Academy of Arts and Sciences (amacad.org); Retrieved April 11, 2012
  5. ↑ TL Orr-Weaver: The 2003 George W. Beadle Medal; Gerald M. Rubin and Allan C. Spradling. In: Genetics. Volume 164, No. 4, August 2003, pp. 1248-1249, ISSN  0016-6731 . PMID 15106662 . PMC 1462668 (free full text).
  6. ↑ Allan C. Spradling at the Gruber foundation (gruberprizes.org); Retrieved April 11, 2012
personal data
SURNAME Spradling, Allan C.
ALTERNATIVE NAMES Spradling, Allan Charles (full name)
BRIEF DESCRIPTION American embryologist and geneticist
DATE OF BIRTH 1949
PLACE OF BIRTH Kalamazoo , Michigan