Bert W. O'Malley

Bert William O'Malley (born December 19, 1936 in Pittsburgh , Pennsylvania ) is an American molecular and cell biologist at Baylor College of Medicine in Houston , Texas .

Life

O'Malley earned a bachelor's degree from the University of Pittsburgh in 1959 and an MD from the University of Pittsburgh School of Medicine in 1963 . As an assistant doctor he worked at Duke University Medical Center before he went to the National Institutes of Health (NIH) in 1965 , from 1967 as head of the department of molecular biology at the National Institute of Child Health and Development (NICHD). After a professorship in reproductive biology (1969–1973) at Vanderbilt University in Nashville , Tennessee , O'Malley was appointed professor of molecular and cellular biology at Baylor College of Medicine in Houston, Texas.

Bert W. O'Malley is married with four children.

Act

O'Malley is recognized as a leader in research into the effects of the female steroid hormones progesterone and estrogen and the basic mechanisms of gene regulation (regulation of gene expression ) in eukaryotes . O'Malley was able to show that steroid hormones and nuclear receptors initially act on the level of gene transcription to regulate mRNA synthesis. O'Malley described the molecular steps from hormone to gene to protein and discovered the "missing link regulators" ( coactivators / corepressors ) that decipher the transcription instructions of the receptors. His work led to the molecular understanding of the effects of hormone antagonists and is of considerable importance in the areas of endocrinology , reproductive technology , hereditary diseases and the treatment of hormone-dependent types of breast and prostate cancer .

Awards (selection)

• 1979 Dickson Prize in Medicine
• 1988 Fred Conrad Koch Award
• 1992 membership in the National Academy of Sciences
• 1996 membership in the American Academy of Arts and Sciences
• 2001 Antonio Feltrinelli Prize
• 2005 Pasarow Award
• 2007 National Medal of Science
• 2011 Ernst Schering Prize
• 2013 Endocrine Regulation Prize
• 2018 Louisa Gross Horwitz Prize

O'Malley holds honorary doctorates from the following universities: New York Medical College , Karolinska Institutet , National University of Ireland , University of Maryland , University of Pennsylvania , University of Pittsburgh , University of Athens .

literature

• BW O'Malley: A life-long search for the molecular pathways of steroid hormone action. In: Molecular endocrinology (Baltimore, Md.). Volume 19, No. 6, June 2005, pp. 1402-1411, ISSN  0888-8809 . doi: 10.1210 / me.2004-0480 . PMID 15914709 .

Web links

• Bert W. O'Malley, MD at Baylor College of Medicine (bsm.edu); Retrieved April 13, 2012
• Prof. Bert W. O'Malley, MD , curriculum vitae (PDF, 43 kB) at the Schering Foundation (scheringstiftung.de); Retrieved April 13, 2012
• Brian York and Bert W. O'Malley at the Journal of Molecular Biology (jbc.org); Retrieved April 13, 2012

Individual evidence

1. ↑ ^{a b} Bert W. O'Malley. In: nationalmedals.org. National Science & Technology Medal Foundation, accessed January 8, 2020 . 
2. ^ Dickson Prize in Medicine Winners at the University of Pittsburgh (pitt.edu); Retrieved April 13, 2012
3. ↑ Book of Members 1780 – present, Chapter O. (PDF; 289 kB) In: American Academy of Arts and Sciences (amacad.org). Accessed August 27, 2019 . 
4. ^ Premi Feltrinelli 1950–2011. Accademia dei Lincei , accessed August 27, 2019 . 
5. ↑ Bert W. O'Malley at the National Science Foundation (nsf.gov); Retrieved April 13, 2012
6. ^ Bert W. O'Malley - Ernst Schering Prize 2011. Schering Foundation , accessed on August 27, 2019 .