Bruce M. Spiegelman

Bruce Michael Spiegelman (born November 14, 1952 in Bay Shore , New York ) is an American cell biologist at Harvard Medical School . He is best known for his contributions to the function, pathophysiology and differentiation of adipose tissue .

Live and act

Spiegelman received a BA from the College of William and Mary in 1974 and a Ph.D. from Princeton University in 1978. in biochemistry . He worked as a postdoctoral fellow at the Massachusetts Institute of Technology . In 1982 he received a first professorship (assistant professor) for pharmacology at Harvard Medical School and the Dana-Farber Cancer Institute , in 1987 he became an associate professor for biochemistry and molecular pharmacology. Since 1991 he has held a full professorship, from 1993 for cell biology . Since 2008 he has been Stanley J. Korsmeyer Professor of Cell Biology and Medicine at Harvard Medical School . In addition, he has been Director of the Center for Energy Metabolism and Chronic Disease at the Dana-Farber Cancer Institute since 2006 .

Spiegelman deals with the transcriptional basis of the energy metabolism of mammals, in particular adipogenesis ( differentiation of adipocytes ). The nuclear receptor PPARγ was identified as the central regulator of the differentiation of fat cells and insulin resistance and its importance for the growth of epithelial cells was shown - also in cancer forms that originate from these cells. PPARγ ligands have been tested as anti-cancer agents. Further work dealt with PGC-1 as a coactivator of transcription in various processes, especially gluconeogenesis in the liver .

Awards (selection)

• 1997 Heinrich Wieland Prize
• 2002 member of the American Academy of Arts and Sciences
• 2002 member of the National Academy of Sciences
• 2003 Rolf Luft Award
• 2006 Corresponding member of the European Molecular Biology Organization (EMBO)
• 2012 Banting Medal of the American Diabetes Association
• 2013 Manpei Suzuki International Prize for Diabetes Research
• 2014 member of the National Academy of Medicine
• 2015 InBev-Baillet Latour Health Prize

literature

• P. Nair: QnAs with Bruce M. Spiegelman. In: Proceedings of the National Academy of Sciences . 108, 2011, p. 19121, doi: 10.1073 / pnas.1117668108 .

Web links

• Bruce Spiegelman at Harvard Medical School (harvard.edu)
• Spiegelman Lab at Harvard Medical School (harvard.edu)
• CV (PDF, 428 kB, as of 2016) at the University of Virginia (virginia.edu)

Individual evidence

1. ↑ 1990 - 1999 - Heinrich Wieland Prize - Homepage. In: heinrich-wieland-prize.de. Retrieved December 23, 2016 . 
2. ↑ Book of Members 1780 – present (PDF, 1.2 MB) at the American Academy of Arts and Sciences (amacad.org); accessed on December 23, 2016.
3. ↑ Bruce Spiegelman. In: nasonline.org. Retrieved December 23, 2016 . 
4. ^ American Diabetes Association Announces Award Winners. In: diabetes.org. June 5, 2012, accessed December 23, 2016 . 
5. ↑ https://www.manpeisuzukiprize.org/winners/2013.html
6. ↑ Prix ​​de la santé (PDF, 629 kB) at the InBev Baillet-Latour-Foundation (fondsbailletlatour.com); accessed on December 23, 2016.