Celiprolol
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( R ) -Celiprolol (top) and ( S ) -Celiprolol (bottom), 1: 1 mixture of stereoisomers | ||||||||||||||||||||||
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Non-proprietary name | Celiprolol | |||||||||||||||||||||
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Drug information | ||||||||||||||||||||||
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Mechanism of action |
selective blockade of β1 receptors |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Celiprolol , a drug from the group of β-receptor blockers , is used to treat high blood pressure and coronary artery disease .
Clinical information
Celiprolol is a moderately effective antagonist of β 1 -adrenoceptors and a partial agonist of β 2 -adrenoceptors , with a half-life of four to twelve hours and a duration of action of up to one day. The bioavailability of Celiprolol is 50%. As a β 2 -adrenoceptor agonist, celiprolol actively leads to vasodilation of peripheral vessels. Elimination occurs mainly through the kidneys. Use in the presence of severe renal insufficiency is contraindicated .
Other Information
The peculiarity of celiprolol and some other beta blockers ( acebutolol , oxprenolol and pindolol ) is their intrinsic sympathomimetic activity ( ISA , see intrinsic activity ).
Trade names
Selectol (D, A, CH)
with chlorthalidon : Selecturon (A)
Individual evidence
- ^ A b The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 324, ISBN 978-0-911910-00-1 .
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Data sheet CELIPROLOL HYDROCHLORIDE CRS (PDF) at EDQM , accessed on July 19, 2008.
literature
- T. Karow, R. Lang-Roth: General and special pharmacology and toxicology . 2003, pp. 62-66.
- G. Herold: Internal Medicine . 2004.
- E. Mutschler, drug effects, 7th edition 1996, WVG Stuttgart, ISBN 3-8047-1377-7 .