Cetyl pyridinium chloride

Structural formula
General
Non-proprietary name	Cetyl pyridinium chloride
other names	1-hexadecylpyridinium chloride ( IUPAC ); Cetylpyridinii chloridum ( Latin ); CPC;
Molecular formula	C 21 H 38 ClN
Brief description	colorless crystal powder with a slight characteristic odor
External identifiers / databases
ECHA InfoCard	100.004.177
PubChem	31239
Wikidata	Q418318
Drug information
ATC code	R02 AA06
Drug class	Antiseptics
properties
Molar mass	339.99 g mol −1
Physical state	firmly
Melting point	83-85 ° C
solubility	soluble in water (50 g l −1 at 20 ° C); good in chloroform , dichloromethane and ethanol ; hardly soluble in benzene , toluene and diethyl ether ;
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
H and P phrases	H: 301-330-315-318-335-400
	P: 260-273-280-284-301 + 310-305 + 351 + 338
Toxicological data	200 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cetylpyridinium chloride is a quaternary ammonium compound which, due to its antiseptic effect, is used as a medicinal substance in lozenges and mouthwash solutions and sprays to treat infections and inflammation of the oral cavity and the pharynx and to relieve sore throats and swallowing difficulties . The substance is also used as a preservative to preserve pharmaceuticals and is also contained in toothpaste and liquid dental care products to prevent plaque and gingivitis .

Medicines with cetylpyridinium chloride as an active ingredient do not usually require a prescription and are available in pharmacies as so-called OTC drugs . The therapeutic effectiveness for the treatment of infections in the mouth and throat area has not been proven by meaningful clinical studies and, depending on the form of use, is sometimes controversial, as the substance is quickly washed out of the oral cavity by the saliva . For this reason, it is used in combination with other active ingredients in some medicines.

Trade names

Monopreparations

Anginetten (D), Dobendan (D, A), Optisana throat tablets (D), Heilusan throat tablets (D), Doreperol (A), Halset (A), Medicazin throat tablets (D)

Combination preparations

Angina MCC (CH), Anginazol (CH), Anginex (A), Citropain (CH), Coldistan (A), Dentinox (A), Dobendan Strepsils Dolo (D), Fentrinol (A), Gem Halsweh (CH), Gurfix (A), Hextriletten (CH), Lidazon (CH), Lysopain (CH), Mebucaine (CH), Neo-Angin (CH), Otothricinol (CH), Septolete (D), Wick Sulagil (D), dm the healthy one Plus gargle solution (D) with aluminum chloride

Individual evidence

↑ ^a ^b ^c ^d ^e entry on cetylpyridinium chloride. In: Römpp Online . Georg Thieme Verlag, accessed on November 11, 2014.
↑ ^a ^b ^c Entry on cetylpyridinium chloride in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
↑ Red List online, as of October 2009.
↑ AM comp. d. Switzerland, as of October 2009.
↑ AGES-PharmMed, as of October 2009.

[RÖMPP-1] ↑ ^a ^b ^c ^d ^e entry on cetylpyridinium chloride. In: Römpp Online . Georg Thieme Verlag, accessed on November 11, 2014.

[GESTIS-2] Entry on cetylpyridinium chloride in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .

[3] Red List online, as of October 2009.

[4] AM comp. d. Switzerland, as of October 2009.

[5] AGES-PharmMed, as of October 2009.