Charles Leblond

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Charles Philippe Leblond (born February 5, 1910 in Lille , † April 10, 2007 in Montreal ) was a French-Canadian physician and cell biologist . He is known as a pioneer in autoradiography and stem cell research .

Life

Leblond studied medicine at the Sorbonne and received his doctorate there in 1934 , with a thesis on the histochemical concentration of ascorbic acid in the body (he found a concentration in steroid-secreting cells). After a stay as a post-doctoral student and Rockefeller scholarship at Yale University , where he also met his future wife Gertrude Sternschus, he worked in Paris on radioactive isotopes for medical research and autoradiography. In 1941 he continued this at McGill University . There he was first assistant lecturer in histology , 1943 assistant professor , 1946 associate professor and 1948 professor of anatomy . From 1957 to 1974 he held the chair for anatomy there. After his retirement , he continued his research at the National Institutes of Health as a Fogarty Scholar. He remained scientifically active into old age and published his last essay in 2006.

During the Second World War he was a medical examiner with the Forces françaises libres . Then he continued his step-by-step development of autoradiographic techniques with ever higher resolution. With autoradiographic techniques, he was able to show that the DNA in the body's cells is constantly renewed and was thus able to identify quantitative differences in the renewal cycles of different cells and identify stem cells. He first found this by studying the production of spermatocytes.

He published around 430 scientific papers.

Leblond used autoradiography to study the dynamics and location of various processes in the body such as tissue renewal and processing of various endogenous substances and protein synthesis . In 1953 he also found evidence of the replication of DNA during cell formation (published a little after the classic work by James D. Watson and Francis Crick ). In 1962 he discovered axonal transport.

Honors

In 1965 he received the Canada Gairdner International Award , in 1961 the Flavelle Medal and in 1983 the McLaughlin Medal of the Royal Society of Canada . He was a Fellow of the Royal Society of Canada (1951), the Royal Society (1965) and a member of the American Academy of Arts and Sciences (1970). He became an officer in 1977 and Companion of the Order of Canada in 1999 . In 2001 he became a Grand Officer of the National Order of Québec. He has received five honorary doctorates ( Acadia University , McGill University , Montreal University , York University , Sherbrooke University ). In 1995 he was inducted into the Canadian Medical Hall of Fame .

Private

After the death of his first wife in 2000 (with whom he had three sons and a daughter), he married a childhood friend in 2001.

literature

  • G. Bennett: Charles Philippe Leblond. February 5, 1910 - April 10, 2007. In: Biographical Memoirs of Fellows of the Royal Society. Volume 54, 2008, p. 17

Web links

Individual evidence

  1. ^ Y. Clermont, CP Leblond: Renewal of spermatogonia in the rat testis. In: Am. J. Anat. Volume 93, 1953, pp. 475-502
  2. ↑ CE Stevens, R. Daoust, Leblond: Rate of synthesis of deoxyribonucleic acid and mitotic rate in liver and intestine. In: J Biol Chem . Volume 202, 1953, pp. 177-186, published May, the Watson-Crick paper in Nature in April
  3. ^ B. Droz, Leblond: Migration of proteins along the axons of the sciatic nerve. In: Science . Volume 137, 1962, pp. 1047-1048
personal data
SURNAME Leblond, Charles
ALTERNATIVE NAMES Leblond, Charles Philippe (full name)
BRIEF DESCRIPTION French-Canadian physician and cell biologist
DATE OF BIRTH February 5, 1910
PLACE OF BIRTH Lille
DATE OF DEATH April 10, 2007
Place of death Montreal