Chlormephos

Structural formula
General
Surname	Chlormephos
other names	O, O- diethyl- S - (chloromethyl) dithiophosphate; S - (chloromethyl) - O, O -diethyldithiophosphate; Dotan; S - (chloromethyl) - O, O -diethylphosphorodithioate; Dithiophosphoric acid S - (chloromethyl) - O, O -diethyl ester;
Molecular formula	C 5 H 12 ClO 2 PS 2
Brief description	colorless liquid
External identifiers / databases
EC number	246-538-1
ECHA InfoCard	100.042.292
PubChem	32739
Wikidata	Q421506
properties
Molar mass	234.71 g mol −1
Physical state	liquid
density	1.260 g cm −3
boiling point	81–85 ° C at 0.13 mbar
Vapor pressure	0.076 mbar (30 ° C)
solubility	practically insoluble in water
safety instructions
H and P phrases	H: 300-310-410
	P: 264-273-280-301 + 310-302 + 350-310
Toxicological data	7 mg kg −1 ( LD 50 , rat , oral ) ; > 1600 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Chlormephos is a chemical compound from the group of organic chlorine compounds and thiophosphoric acid esters .

Extraction and presentation

Chlormephos can be obtained by reacting sodium O, O diethyldithiophosphate with bromochloromethane .

properties

Chlormephos is a colorless liquid that is poorly soluble in water.

use

Chlormephos is used as an insecticide against soil insects such as wireworms on a number of plants. It acts as an acetylcholinesterase inhibitor and its main metabolite is ethione .

Admission

In the EU countries such as Germany and Austria as well as in Switzerland, no pesticides are permitted that contain Chlormephos as an active ingredient.

Web links

Entry to Chlormephos in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on August 1, 2013.

Individual evidence

↑ Data sheet Chlormefos PESTANAL at Sigma-Aldrich , accessed on October 16, 2016 ( PDF ).
↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Entry on Chlormephos in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .
↑ Entry on Chlormephos in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Thomas A. Unger: Pesticide synthesis handbook . 1996, ISBN 978-0-8155-1401-5 , pp. 346 ( limited preview in Google Book search).
^ Terence Robert Roberts, DH Hutson: Metabolic pathways of agrochemicals, Part 2 . Royal Soc of Chemistry, 1999, ISBN 978-0-85404-499-3 ( page 231 in the Google book search).
↑ General Directorate Health and Food Safety of the European Commission: Entry on Chlormephos in the EU pesticide database ; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; Retrieved March 3, 2016.

[Sigma-1] Data sheet Chlormefos PESTANAL at Sigma-Aldrich , accessed on October 16, 2016 ( PDF ).

[GESTIS-2] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Entry on Chlormephos in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .

[CLP_100.042.292-3] Entry on Chlormephos in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[unger-4] Thomas A. Unger: Pesticide synthesis handbook . 1996, ISBN 978-0-8155-1401-5 , pp. 346 ( limited preview in Google Book search).

[buch-5] Terence Robert Roberts, DH Hutson: Metabolic pathways of agrochemicals, Part 2 . Royal Soc of Chemistry, 1999, ISBN 978-0-85404-499-3 ( page 231 in the Google book search).

[PSM-6] General Directorate Health and Food Safety of the European Commission: Entry on Chlormephos in the EU pesticide database ; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; Retrieved March 3, 2016.