David Julius

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David Julius, 2016

David Jay Julius (born November 4, 1955 in Brighton Beach , Brooklyn , New York City ) is an American sensory physiologist and professor at the University of California, San Francisco (UCSF).

Life

Julius acquired in 1977 a Bachelor in Life Sciences ( Life Sciences ) at the Massachusetts Institute of Technology (MIT) in Cambridge , Massachusetts , where he first research experience in the laboratory of Alexander Rich gained. In 1984 he received a Ph.D. from Jeremy Thorner and later Nobel Prize winner Randy Schekman. in Biochemistry from the University of California, Berkeley in Berkeley , California . Julius worked as a postdoctoral fellow with the later Nobel Prize winner Richard Axel at Columbia University in New York City. In 1990 Julius became a faculty member at the University of California, San Francisco (UCSF) in San Francisco , California, where he now (as of 2020) heads the Department of Physiology .

Julius' wife, Holly Ingraham , is also a professor of physiology at UCSF. The couple has a son.

Act

Julius was able to gain fundamental knowledge about the molecular and functional properties of ionotropic receptors , which react to serotonin and ATP , or which are responsible for modalities of the pain , heat and cold receptors . Julius' discoveries are central to understanding the molecular basis of temperature perception, for which cold and warmth are integrated.

Julius discovered that the TRPV1 channel is a capsaicin receptor that mediates the body's response to various stimuli such as temperature, inflammation, and other forms of tissue damage. This was an important finding for the treatment of chronic pain syndrome and other syndromes associated with neurogenic inflammation , osteoarthritis , cancer or asthma . The understanding of allodynia and hyperalgesia was also promoted, a pain sensation with stimuli that are usually not pain-inducing or an excessive pain sensation with only minor pain stimuli.

Julius is u. a. Editor of the prestigious Annual Review of Physiology .

Since 2014 Thomson Reuters has counted him among the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of his citations .

Awards (selection)

Web links

Individual evidence

  1. 49th Annual Faculty Research Lecture at ucsf.edu; accessed on May 27, 2020.
  2. 2014 Predictions at Thomson Reuters (sciencewatch.com); Retrieved September 25, 2014
  3. Book of Members 1780 – present, Chapter J. (PDF; 354 ​​kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved April 5, 2018 .
  4. Zülch Prize at mpg.de; accessed on May 27, 2020.
  5. recipients of the passano laureate and physician scientist awards. In: passanofoundation.org. Passano Foundation, accessed May 27, 2020 .
  6. ^ The Shaw Prize in Life Science and Medicine 2010 at shawprize.org; accessed on May 27, 2020.
  7. ^ Prince of Asturias Awards. Technical & Scientific Research 2010 at fpa.es; accessed on May 27, 2020.
  8. Julius, David. In: mta.hu. Retrieved April 5, 2018 (Hungarian).