Desmedipham

Structural formula
General
Surname	Desmedipham
other names	Desmediphan; Ethyl 3-phenylcarbamoyloxyphenyl carbamate; [3- (ethoxycarbonylamino) phenyl] phenyl carbamate;
Molecular formula	C 16 H 16 N 2 O 4
Brief description	colorless and odorless crystals
External identifiers / databases
EC number	237-198-5
ECHA InfoCard	100.033.802
PubChem	24743
Wikidata	Q3024527
properties
Molar mass	300.31 g mol −1
Physical state	firmly
density	0.620 g cm −3
Melting point	120 ° C
solubility	practically insoluble in water (7 mg l −1 at 20 ° C)
safety instructions
GHS hazard labeling from Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary Caution
H and P phrases	H: 410
	P: 273-391-501
Toxicological data	9600 mg kg −1 ( LD 50 , rat , oral ) ; > 2000 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Desmedipham is a chemical compound from the group of phenylcarbamates and bis carbamate .

Extraction and presentation

Desmedipham can be obtained by reacting ethyl chloroformate and m- aminophenol with phenyl isocyanate .

use

Desmedipham was founded in 1970 by Schering AG (later Aventis , now Bayer CropScience ) as a selective, systemic post-emergence - Herbicide introduced. It is mainly used in beet cultivation (especially against bent back amaranth / Amaranthus retroflexus ) and in strawberry crops against weeds, e.g. T. in combination with Phenmedipham .

Desmedipham inhibits the D1 protein on photosystem II .

Admission

In the European Union, with effect from March 1, 2005, Desmedipham was added to the list of permissible active ingredients in pesticides for use as a herbicide .

Desmedipham is approved as an active ingredient in crop protection products in Germany, Austria and Switzerland under the trade names Betanal and Betamax. The approvals of plant protection products with Desmedipham in the EU ended on January 1, 2020. The sales and use-by deadlines of July 1, 2020 apply.

Web links

EU approval for the active ingredient desmedipham in plant protection products not renewed

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g Entry on Desmedipham in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .
↑ Entry on Desmedipham in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Desmedipham data sheet , PESTANAL at Sigma-Aldrich , accessed on May 20, 2017 ( PDF ).
↑ Entry on Desmedipham. In: Römpp Online . Georg Thieme Verlag, accessed on May 28, 2014.
↑ Directive 2004/58 / EC of the Commission of April 23, 2004 (PDF) amending Council Directive 91/414 / EEC to include the active substances alpha-cypermethrin, benalaxyl, bromoxynil, desmedipham, ioxynil and phenmedipham.
↑ General Directorate Health and Food Safety of the European Commission: Entry on Desmedipham in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; Retrieved February 19, 2016.
↑ BVL - Technical reports - Revocation of the approval of plant protection products with the active ingredient Desmedipham on January 1, 2020. Accessed on February 11, 2020 .

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g Entry on Desmedipham in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .

[CLP_100.033.802-2] Entry on Desmedipham in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[Sigma-3] Desmedipham data sheet , PESTANAL at Sigma-Aldrich , accessed on May 20, 2017 ( PDF ).

[roempp-4] Entry on Desmedipham. In: Römpp Online . Georg Thieme Verlag, accessed on May 28, 2014.

[5] Directive 2004/58 / EC of the Commission of April 23, 2004 (PDF) amending Council Directive 91/414 / EEC to include the active substances alpha-cypermethrin, benalaxyl, bromoxynil, desmedipham, ioxynil and phenmedipham.

[PSM-6] General Directorate Health and Food Safety of the European Commission: Entry on Desmedipham in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; Retrieved February 19, 2016.

[7] BVL - Technical reports - Revocation of the approval of plant protection products with the active ingredient Desmedipham on January 1, 2020. Accessed on February 11, 2020 .