Douglas Coleman
Douglas Leonard Coleman (born October 6, 1931 in Stratford , Ontario , † April 16, 2014 in Lamoine , Maine ) was a Canadian biochemist and researcher at the Jackson Laboratory . His work was fundamental to the study of obesity and diabetes mellitus .
Life
Coleman earned a bachelor's degree in chemistry from McMaster University in Hamilton in 1954, a master's degree from the University of Wisconsin – Madison in 1956, and a Ph.D. in 1958. there.
Coleman spent his scientific career - until his retirement in 1991 - at the Roscoe B. Jackson Memorial Laboratory (now Jackson Laboratory ) in Bar Harbor , Maine . He started as a research assistant and went through numerous career stages up to head of a research group and (transitional) director.
Since his retirement, Coleman has dedicated himself to ecological issues such as small-scale forest management and landscape protection.
Act
Coleman discovered two mutations in mice : the variant obese can not produce a hormone (known today as leptin ) and tends to become obese - even with reduced food intake; the variant diabetes has the hormone in abundance, but can not utilize it in the hypothalamus and is therefore also prone to obesity. With attempts at parabiosis - the interconnection of parts of the circulation of two test animals, each homozygous for a genetic defect - Coleman was able to develop theories about the effect of the postulated hormone. Coleman also suggested that the widespread prevalence of obesity and diabetes mellitus among modern humans is the result of an evolutionary advantage of heterozygous individuals during periods of starvation. Many of Coleman's considerations were later confirmed by Jeffrey M. Friedman .
Awards (selection)
- 1998 membership in the National Academy of Sciences
- 2005 Gairdner Foundation International Award (together with Jeffrey M. Friedman et al.)
- 2009 Shaw Prize in Life Science and Medicine (together with Jeffrey M. Friedman )
- 2010 Albert Lasker Award for Basic Medical Research (together with Jeffrey M. Friedman )
- 2012 BBVA Foundation Frontiers of Knowledge Award (together with Jeffrey M. Friedman )
- 2013 König Faisal Prize for Medicine (together with Jeffrey M. Friedman )
literature
- Jeffrey Friedman : Douglas Coleman (1931-2014). In: Nature . Volume 509, No. 7502, 2014, p. 564, doi: 10.1038 / 509564a
Web links
- Douglas L. Coleman - Obituary. In: Bangor Daily News of April 17, 2014 (English)
- Douglas Coleman - Obituary. In: The Daily Telegraph of April 17, 2014 (English)
Individual evidence
- ↑ Autobiography of Douglas L Coleman at shawprize.org; Retrieved December 21, 2010
- ↑ Dr. Douglas Coleman, Ph.D. at gairdner.org; Retrieved September 21, 2012
- ^ Shaw Prize in Life Science and Medicine - Press Release at shawprize.org; Retrieved December 21, 2010
- ^ Albert Lasker Basic Medical Research Award 2010 Winners: Douglas Coleman and Jeffrey M. Friedman at laskerfoundation.org; Retrieved December 21, 2010
- ^ King Faisal Prize 2013 for Medicine
| personal data | |
|---|---|
| SURNAME | Coleman, Douglas |
| ALTERNATIVE NAMES | Coleman, Douglas Leonard (full name) |
| BRIEF DESCRIPTION | Canadian biochemist and researcher at the Jackson Laboratory |
| DATE OF BIRTH | October 6, 1931 |
| PLACE OF BIRTH | Stratford , Ontario |
| DATE OF DEATH | April 16, 2014 |
| Place of death | Lamoine , Maine |