Isopropyl acetate

Structural formula
General
Surname	Isopropyl acetate
other names	Isopropyl acetate i- propyl acetate
Molecular formula	C 5 H 10 O 2
Brief description	colorless liquid with a fruity odor
External identifiers / databases
CAS number 108-21-4 EC number 203-561-1 ECHA InfoCard 100.003.238 PubChem 7915 Wikidata Q419799
properties
Molar mass	102.13 g mol −1
Physical state	liquid
density	0.88 g cm −3
Melting point	−73 ° C
boiling point	89 ° C
Vapor pressure	62 hPa at 20 ° C
solubility	little in water (31 g l −1 at 20 ° C) miscible with many organic solvents
Refractive index	1.377
safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary danger H and P phrases H: 225-319-336 EUH: 066 P: 210-305 + 351 + 338-370 + 378-403 + 235
MAK	DFG / Switzerland: 100 ml m −3 or 420 mg m −3
Toxicological data	6750 mg kg −1 ( LD 50 ,  rat ,  oral ) > 17400 mg kg −1 ( LD 50 ,  rabbit ,  transdermal )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Isopropyl acetate is a chemical compound from the group of carboxylic acid esters . It is a colorless, highly flammable and volatile liquid.

Extraction and presentation

The industrial production of isopropyl acetate takes place by esterification of acetic acid with isopropanol at temperatures of 60-80 ° C on strongly acidic cation exchangers as a catalyst .

The reaction is carried out in a fixed bed reactor .

In the laboratory or on a smaller scale, sulfuric acid or p-toluenesulfonic acid is occasionally used as a catalyst .

properties

Isopropyl acetate has a fruity odor when diluted, but a pungent odor when concentrated. Isopropyl acetate hydrolyzes slowly in moist air, liberating acetic acid. It decomposes when exposed to light and at temperatures above 430 ° C.

use

Isopropyl acetate is used as an intermediate in the production of other chemical compounds and as a solvent (e.g. for natural and synthetic resins, oils, fats and plasticizers).

safety instructions

The vapors of isopropyl acetate form an explosive mixture with air (flash point 2 ° C, ignition temperature 425 ° C).

Individual evidence

1. ↑ ^{a b} entry on isopropyl acetate. In: Römpp Online . Georg Thieme Verlag, accessed on November 10, 2014.
2. ↑ ^{a b c d e f g h i j k l m} Entry on isopropyl acetate in the GESTIS substance database of the IFA , accessed on January 10, 2017(JavaScript required) .
3. ↑ Entry on isopropyl acetate at ChemBlink , accessed on February 25, 2011.
4. ↑ Entry on Isopropyl acetate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
5. ↑ Swiss Accident Insurance Fund (Suva): Limit values ​​- current MAK and BAT values (search for 108-21-4 or isopropyl acetate ), accessed on November 2, 2015.
6. ↑ ^{a b} Ying Liu, Jia Liu, Hanzhao Yan, Zheng Zhou, Aidong Zhou: Kinetic Study on Esterification of Acetic Acid with Isopropyl Alcohol Catalyzed by Ion Exchange Resin . In: ACS Omega . 4, No. 21, pp. 19462-19468. doi : 10.1021 / acsomega.9b02994 .
7. ^ Association of authors: Organikum , 19th edition, Johann Ambrosius Barth, Leipzig · Berlin · Heidelberg 1993, ISBN 3-335-00343-8 , p. 420.
8. ^ Klaus Schwetlick et al: Organikum . 24th edition. Wiley-VCH, Weinheim 2015, ISBN 978-3-527-33968-6 .
9. ↑ Information on harmful substances from Enius