Paul Trendelenburg

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Paul Trendelenburg (born March 24, 1884 in Bonn , † November 4, 1931 in Berlin ) was a German doctor , pharmacologist and toxicologist .

Life

He was the son of the former Rostock professor and surgeon Friedrich Trendelenburg from Leipzig . His brothers included the physiologist Wilhelm Trendelenburg , the lawyer Friedrich Trendelenburg , the lawyer Ernst Trendelenburg and the physicist Ferdinand Trendelenburg . Paul attended the humanistic Thomas School in Leipzig until 1902 . He then studied medicine at the Universities of Leipzig , Grenoble and Freiburg . In 1909 he was with at Walther Straub -made of Pharmacology at Freiburg dissertation Comparative study of the mechanism of action and the effect intensity glykositischer heart poisons to Dr. med. PhD. In 1912 he completed his habilitation, again with Straub. Due to tuberculosis, he did not take part in the First World War. Later he was professor of pharmacology and toxicology at the universities of Tartu (1918), as full professor for the first time in Rostock (from May 1919 to 1923), Freiburg im Breisgau (from 1923 to 1927) and Berlin (from 1927). From 1926 he was a board member of the German Pharmacological Society . Paul Trendelenburg died of a "chronic tubercular disease". His son Ullrich Trendelenburg was also a pharmacologist.

tomb

He is buried in the Evangelical Churchyard Nikolassee in Berlin.

Research and Teaching

Trendelenburg worked particularly in the areas of the autonomic nervous system and internal secretion . His research on adrenaline , standardized biological measuring methods for hormone preparations and work on the hypothalamus hormones vasopressin and oxytocin are of particular pharmacological importance . One of his most momentous discoveries was the inhibition of peristalsis in the small intestine in guinea pigs by morphine . It led Hans Kosterlitz to his research on opioids and finally (1975) on the discovery of endogenous opioids . The 75-page article from 1917 in the Archives for Experimental Pathology and Pharmacology was reprinted in 2006 in the same journal, translated into English, with a comment.

Trendelenburg's textbook Basics of the General and Special Drug Ordinance was published in seven editions, the first in 1926, the third to the seventh posthumously, edited by Otto Krayer and Manfred Kiese . The foreword speaks of a critical attitude towards the pharmaceutical industry and alternative medicine to this day : “Since the presentation of pharmaceuticals has been almost completely subject to capitalism, the vast amount of new specialties and the often quite subjective form of their recommendation makes it difficult to form a reliable judgment - all the more so more than the more and more spreading fog of mystical speculative considerations about the nature of medicinal therapy began to cloud the criticism sharpened by the scientific methods of researching the effects of medicinal products. It was the intention of the author, by choosing the most important means and by letting the unimportant or not yet sufficiently tested, help to put the doctor-to-be in a better position to judge when he is on solid ground with his therapeutic action. "

Works

  • Physiological and pharmacological experiments on peristalsis of the small intestine. In: Naunyn Schmiedeberg's Archives for Experimental Pathology and Pharmacology. Volume 81, 1917, pp. 55-129.
  • Basics of the general and special drug regulation , Leipzig 1926.
  • The hormones , Berlin 1929.

Web links

Individual evidence

  1. ↑ Curt Elze : 15 years anatomist in Rostock (1921–1936). In: Scientific journal of the University of Rostock. Volume 17, 1968, pp. 29-38, here: p. 34.
  2. ↑ Richard Sachse, Karl Ramshorn, Reinhart Herz: The teachers of the Thomasschule in Leipzig 1832-1912. The high school graduates of the Thomas School in Leipzig 1845–1912 . BG Teubner Verlag, Leipzig 1912, p. 107.
  3. ↑ Paul Trendelenburg: Comparative study on the mechanism of action and the intensity of action of glycositive cardiac toxins. In: Archives for Experimental Pathology and Pharmacology 1909; 61: 256-273.
  4. ↑ Klaus Starke: The history of the Pharmacological Institute of the University of Freiburg , page 17-27. ( PDF 1.52 MB )
  5. ↑ Thomas Beck : The Rostocker Ordinariate for Pharmacology under Paul Trendelenburg 1919–1923. In: Würzburg medical history reports. Volume 25, 2006, pp. 205-213.
  6. ↑ Curt Elze: 15 years anatomist in Rostock (1921–1936). 1968, p. 34.
  7. ↑ Paul Trendelenburg: Determination of the adrenaline content in normal blood as well as when the effect of a single intravenous adrenaline injection subsides using a physiological measurement method. In: Archives of Experimental Pathology and Pharmacology. Volume 63, 1910, pp. 161-176.
  8. ^ Paul Trendelenburg: The adrenaline secretion under normal and disturbed conditions. In: Results of Physiology. Volume 21, 1923, pp. 500-557.
  9. ↑ Thomas Beck: The Rostock Ordinariate for Pharmacology [...]. 2006, p. 205.
  10. ^ Paul Trendelenburg: Physiological and pharmacological experiments on the small intestinal peristalsis . In: Archives of Experimental Pathology and Pharmacology . 81, 1917, pp. 55-129. doi : 10.1007 / BF01862644 .
  11. ^ Hans W. Kosterlitz: The best laid schemes o'mice an 'men gang aft agley. In: Annual Review of Pharmacology and Toxicology 1979; 19: 1-12.
  12. ^ Wim JEP Lammers, Anne Marijke Lammers-van den Berg, John FB Morrison and Georg A. Petroianu: Translating Trendelenburg; back to the future . In: Naunyn-Schmiedeberg's Archives of Pharmacology . 373, 2006, pp. 134-138. doi : 10.1007 / s00210-006-0051-8 .
  13. ^ Paul Trendelenburg: Physiological and pharmacological investigations of small intestinal peristalsis . In: Naunyn-Schmiedeberg's Archives of Pharmacology . 373, 2006, pp. 101-133. doi : 10.1007 / s00210-006-0052-7 .
  14. ↑ Paul Trendelenburg: Basics of the general and special drug prescription. Leipzig, Vogel 1926.
personal data
SURNAME Trendelenburg, Paul
BRIEF DESCRIPTION German pharmacologist
DATE OF BIRTH March 24, 1884
PLACE OF BIRTH Bonn
DATE OF DEATH November 4, 1931
Place of death Berlin