Ullrich Trendelenburg

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Trendelenburg in Tübingen (1995)

Ullrich Trendelenburg (born December 31, 1922 in Gehlsdorf (Rostock) ; † November 21, 2006 in Tübingen ; full name: Ullrich Georg Trendelenburg ) was a German pharmacologist. From 1968 to 1991 he held the chair for pharmacology and toxicology at the Julius Maximilians University of Würzburg .

Life

Ullrich Trendelenburg was the son of the pharmacologist Paul Trendelenburg and his wife Veronika geb. Wilcken. The paternal grandfather, Friedrich Trendelenburg , was a well-known surgeon. The maternal grandfather, Ulrich Wilcken , was an ancient historian. In his father's pharmacological institute in Berlin, Ullrich met pharmacologists who were opponents of National Socialism, such as Otto Krayer , Edith Bülbring and Marthe Vogt . During the war he enlisted in the air force to avoid the SS . After being a prisoner of war, he studied medicine in Göttingen and Uppsala and was awarded a doctorate in 1952 at the University of Göttingen. med. PhD .

From 1952 to 1956 he worked as a British Council scholar in the Department of Pharmacology at Oxford University with Joshua Harold Burn . Here he married his wife Christel (1922–2008) in 1953, with whom he had a daughter. From 1956 to 1957 he was at the Pharmacological Institute of the University of Mainz with Gustav Kuschinsky , from 1957 to 1968 at the Department of Pharmacology at Harvard Medical School with Otto Krayer. From there he was appointed to the chair for pharmacology and toxicology at the University of Würzburg, which he held until his retirement in 1991. He then lived in Tübingen until his death .

tomb

He is buried in the Evangelical Churchyard Nikolassee in Berlin.

Professional activity

Trendelenburg's main area of ​​research was the pharmacology of the autonomic nervous system and catecholamines . He identified new receptors on autonomous ganglion cells , clarified the mechanisms of hypersensitivity and under-sensitivity to pharmaceuticals , clarified the mode of action of direct and indirect sympathomimetics and described inactivation pathways for catecholamines in which a transport protein and a degrading enzyme are connected in series. He called these inactivation pathways "metabolizing systems".

The discovery of the existence of histamine receptors in the heart, which differed from those previously known, was particularly momentous . They were later referred to as histamine H 2 receptors and sites of action of the therapeutically important H 2 antihistamines such as cimetidine .

In 1957, while studying ganglionic receptors, Trendelenburg found that morphine inhibited the release of the neurotransmitter and catecholamine noradrenaline from sympathetic nerves . Klaus Starke pointed out that Ullrich was thus taking up a trace of his father Paul, who had found in 1917 that morphine inhibited the peristalsis reflex in guinea pigs . Ullrich did not quote his father in 1957. “The historian may be impressed by the parallel: Forty years later, the father observed presynaptic inhibition by morphine in the intestinal nervous system (inhibition of the release of acetylcholine ) and the son observed presynaptic inhibition by morphine in the sympathetic nervous system (inhibition of the release of noradrenaline)."

From 1975 to 1979 Trendelenburg was president of the German Pharmacological Society , from 1969 to 1991 editor of Naunyn-Schmiedeberg's archive for experimental pathology and pharmacology . He served the International Union of Pharmacology (IUPHAR) from 1981 to 1998, for example as Vice President.

Sensitized through his friendship with victims of National Socialism, after his retirement he presented Otto Krayer's unique courage towards National Socialism and collected the biographies of persecuted pharmacologists.

Honors

Trendelenburg was an honorary member of the Polish, Indian, Czechoslovak, German and Venezuelan Pharmacological Societies and was an honorary doctor of the medical faculties of five universities. In 1984, friends and students published the book Neuronal and Extraneuronal Events in Autonomic Pharmacology in his honor . In a “Tribute to Ullrich G. Trendelenburg” it says: “Trendelenburg's impact on pharmacology around the world has been enormous. Young scientists have come from every continent to work in his laboratory at Harvard or Würzburg and all have benefited richly from his remarkable scientific insight, high standards, and absolute insistence on careful and thorough experiments. ... The warmth of both Ullrich and Christel Trendelenburg makes everyone who works in his laboratory a member of the family. “In 1998 the German Pharmacological Society awarded him the Schmiedeberg plaque .

literature

Web links

Commons : Ullrich Trendelenburg  - Collection of images, videos and audio files

Individual evidence

  1. ↑ Dissertation: About the effect of some cough suppressants on cough threshold and breathing . In: Acta physiologica Scandinavica 21, 1950, pp. 174-186.
  2. ↑ Starke 2007 and Guimarães 2011; Karl-Heinz Graefe: Institute for Pharmacology and Toxicology, Medical Faculty of the Julius Maximilians University of Würzburg (1968–1991). The Trendelenburg years. In: Athineos Philippu (Ed.): History and work of the pharmacological, clinical-pharmacological and toxicological institutes in German-speaking countries. Berenkamp-Verlag, Innsbruck 2004, ISBN 3-85093-180-3 , pp. 664-668.
  3. ^ Ulrich Trendelenburg: Some aspects of the pharmacology of autonomic ganglion cells. In: Reviews of Physiology, Biochemistry and Experimental Pharmacology 59, 1967, pp. 1-85.
  4. ↑ Ullrich Trendelenburg: supersensitivity and subsensitivity to Sympathomimetic cardamines. In: Pharmacological Reviews 15, 1963, pp. 225-276 ( PDF ).
  5. ^ Ullrich Trendelenburg: The metabolizing systems involved in the inactivation of catecholamines. In: Naunyn-Schmiedeberg's Archives of Pharmacology 332, 1986, pp. 201-207 doi : 10.1007 / BF00504854 .
  6. ↑ Ulrich Trendelenburg: The action of histamine and 5-hydroxytryptamine on isolated mammalian atria . In: Journal of Pharmacology and Experimental Therapeutics 130, 1960, pp. 450-460.
  7. ↑ Klaus Starke: There can be a trace of our earth floors - on pharmacologists and pharmacology . In: Naunyn-Schmiedeberg's Archives of Pharmacology . tape 380 , 2009, p. 465-471 , doi : 10.1007 / s00210-009-0443-7 .
  8. ^ Ulrich Trendelenburg: The action of morphine on the superior cervical ganglion and on the nictitating membrane of the cat . In: British Journal of Pharmacology . tape 12 , 1975, p. 79-85 , doi : 10.1111 / j.1476-5381.1957.tb01366.x .
  9. ↑ Strong 2007.
  10. ^ Ullrich Trendelenburg: Otto Krayer (October 22, 1899 to March 18, 1982) and the "Law for the Restoration of the Professional Civil Service" (April 1933). In: DGPT Mitteilungen 16, 1995, pp. 33-34.
  11. ^ Ullrich Trendelenburg: Persecuted German-speaking pharmacologists 1933–1945. Frechen, Dr. Schrör Verlag, 2006. ISBN 3-9806004-7-5 .
  12. ^ William W. Fleming, Karl-Heinz Graefe, SZ Langer, Norman Weiner: Neuronal and Extraneuronal Events in Autonomic Pharmacology. Raven Press, New York 1984, ISBN 0-88167-001-4 .
  13. ↑ Strong 2007.
personal data
SURNAME Trendelenburg, Ullrich
ALTERNATIVE NAMES Trendelenburg, Ullrich Georg (full name)
BRIEF DESCRIPTION German pharmacologist
DATE OF BIRTH December 31, 1922
PLACE OF BIRTH Gehlsdorf (Rostock)
DATE OF DEATH November 21, 2006
Place of death Tübingen