Peter K. Vogt

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Peter Klaus Vogt (born March 10, 1932 in Broumov , then Braunau, Czechoslovakia ) is a German -born American molecular biologist , virologist and geneticist . He is primarily concerned with retroviruses and viral and cellular oncogenes .

Life

After he fled the Soviet-occupied zone of Germany to the West in 1950, Vogt studied biology at the University of Würzburg . From 1955 he worked on his doctoral thesis at the Max Planck Institute for Virology in Tübingen and received his doctorate in 1959 at the University of Tübingen . He then accepted a postdoctoral position (as a Damon Runyon Cancer Research Fellow ) in Harry Rubin's laboratory at the University of California at Berkeley and began working on the Rous sarcoma virus . In 1962 he moved to the University of Colorado in Denver , where he was first assistant and then associate professor . From 1967 to 1971 he was Associate Professor and then Professor of Microbiology at the University of Washington in Seattle before moving to the University of Southern California as Hastings Professor in 1971 , where he became Head of the Department of Microbiology in 1980. Since 1993 he has been a professor at the Scripps Research Institute in La Jolla.

plant

At the beginning of his scientific career, Vogt determined the interaction of the retroviral envelope proteins and their cellular receptors as the first condition for infection. On the basis of this work it was possible for him to arrange the retroviruses of the poultry into several strictly defined groups. This grouping made important cell biological work on retroviruses possible. In Seattle he turned to the genetics of the retroviruses. Together with his colleague Kumao Toyoshima , he isolated the first temperature-sensitive mutants of a retrovirus and thus showed that virus-induced cancer is based on a function of the viral genome. In collaboration with the biochemist Peter Duesberg , he then defined the viral genome segment that is necessary for tumor generation, and thus discovered the first retroviral oncogene, src (see tyrosine kinase Src ). His work on mutants of the Rous sarcoma virus enabled Michael Bishop and Harold Varmus to demonstrate the cellular origin of all oncogenes. Through his extensive studies of poultry retroviruses, Vogt also discovered other oncogenes that now play an important role in human cancer, such as Myc (together with Bister and Duesberg), jun (with Maki and Bos) and p3k (with Chang).

Awards, honors and memberships

Vogt's work has received numerous awards and honors, including the Irene Vogeler Prize (1976), Alexander von Humboldt Prize (1984), Ernst Jung Prize (1985), Robert J. and Claire Pasarow Award (1987) , Paul Ehrlich and Ludwig Darmstaedter Prize (1988), Bristol Myers Squibb Prize (1989), Charles S. Mott Prize (1991), the Szent Györgyi Prize (2010), the Loeffler Frosch Medal (2010 ), the Pezcoller Foundation-AACR International Award for Cancer Research (2013), the IHV Lifetime Achievement Award for Scientific Contributions (2016), and the AICF Prize for Scientific Excellence in Medicine (2017). In 2019 he was awarded the Louisa Gross Horwitz Prize . In 1995 he was awarded an honorary doctorate from the University of Würzburg . Vogt is a member of numerous national and international scientific societies, such as the National Academy of Sciences USA , the American Philosophical Society , the American Academy of Arts and Sciences , the German National Academy of Scientists Leopoldina and the American Academy of Microbiology (AAM) of the American Society for Microbiology (ASM). He is also active in scientific committees and editorial advisory boards, e. B. in the Sidney Kimmel Foundation for Cancer Research (since 2005), in the Editorial Board of the Proceedings of the National Academy of Arts and Sciences, USA (since 2000) and in the editorial board for Current Topics in Microbiology and Immunology (Springer, since 1967 ).

Private

Vogt is also a committed painter. During his studies in Würzburg he took lessons from the landscape painter Josef Versl (1901–1993).

Web links

Individual evidence

  1. ↑ Life data from American Men and Women of Science , Thomson Gale 2005
  2. ^ Jung Prize Laureates . Archived from the original on February 10, 2018. Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved February 9, 2018. @1@ 2Template: Webachiv / IABot / www.jung-stiftung.de
  3. ^ Paul Ehrlich and Ludwig Darmstaedter Prize Laureates .
  4. ^ Cancer Research Cover June 15, 1989 .
  5. ^ Vogt, PK (1992), Jun: A transcription factor becomes oncogenic. Cancer, 69: 2610-2614. .
  6. ↑ Pezcoller-AACR Award .
  7. ^ IHV Lifetime Achievement Award .
  8. ↑ AICF Prize for Scientific Excellence in Medicine .
  9. ↑ Louisa Gross Horwitz Prize 2019
  10. ↑ Member entry by Prof. Dr. Peter K. Vogt (with picture) at the German Academy of Sciences Leopoldina , accessed on August 27, 2016.
personal data
SURNAME Vogt, Peter K.
ALTERNATIVE NAMES Vogt, Peter Klaus (full name)
BRIEF DESCRIPTION American molecular biologist, virologist and geneticist of German origin
DATE OF BIRTH March 10, 1932
PLACE OF BIRTH Broumov