Propionic anhydride

Structural formula
General
Surname	Propionic anhydride
other names	Propionyl oxide
Molecular formula	C 6 H 10 O 3
Brief description	colorless liquid with an unpleasant, pungent odor
External identifiers / databases
EC number	204-638-2
ECHA InfoCard	100.004.218
PubChem	31263
Wikidata	Q418066
properties
Molar mass	130.14 g mol −1
Physical state	liquid
density	1.02 g cm −3
Melting point	−45 ° C
boiling point	167 ° C
Vapor pressure	1.42 h Pa (20 ° C)
solubility	decomposes in water
Refractive index	1.404 (20 ° C)
safety instructions
GHS hazard labeling from Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary danger
H and P phrases	H: 314
	P: 301 + 330 + 331-305 + 351 + 338-309 + 310-280
Toxicological data	2360 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Propionic anhydride is a chemical compound from the group of carboxylic acid anhydrides .

Extraction and presentation

Propionic anhydride, by dehydration of propionic acid with ketene obtained:

2

properties

Propionic anhydride has a pH of 2.5 and a viscosity of 1.144 mPa.s at 20 ° C. In water it decomposes to propionic acid.

use

Propionic anhydride is used as an intermediate in the production of other chemical compounds (e.g. propiophenone , fentanyl ).

safety instructions

The vapors of propionic anhydride can form an explosive mixture with air ( flash point 74 ° C, ignition temperature 315 ° C). Due to exothermic hydrolysis to form an acid (propionic acid), it is also very irritating to corrosive.

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h Entry on propionic anhydride in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .
↑ Propionic anhydride data sheet from Sigma-Aldrich , accessed on February 23, 2010 ( PDF ).

↑ Entry on Propionic anhydride in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

↑ Data sheet propionic anhydride (PDF) from Merck , accessed on February 23, 2010.

↑ Williams, JW and Krynitsky, JA: n-Caproic Anhydride In: Organic Syntheses . 21, 1941, p. 13, doi : 10.15227 / orgsyn.021.0013 ; Coll. Vol. 3, 1955, p. 164 ( PDF ).

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h Entry on propionic anhydride in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .

[2] Propionic anhydride data sheet from Sigma-Aldrich , accessed on February 23, 2010 ( PDF ).

[CLP_100.004.218-3] Entry on Propionic anhydride in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[4] Data sheet propionic anhydride (PDF) from Merck , accessed on February 23, 2010.

[5] Williams, JW and Krynitsky, JA: n-Caproic Anhydride In: Organic Syntheses . 21, 1941, p. 13, doi : 10.15227 / orgsyn.021.0013 ; Coll. Vol. 3, 1955, p. 164 ( PDF ).