The sacbrood virus ( SBV ) is an insect virus from the family Iflaviridae in order picornavirales that in larvae of the honeybee called sacbrood caused Disease. It was first identified by L. Bailey in 1964 and described as a viral pathogen.
The virion of the SBV consists of an unenveloped capsid , which is probably composed of three different viral structural proteins VP1 to VP3 and has a diameter of 26 nm. The capsid is very environmentally stable and resistant to detergents . Inside the capsid is an approximately 8800 nt , single-stranded, linear RNA with positive polarity that codes for a large polyprotein in a single open reading frame . The reading frame is flanked by a 5 'and 3' non-coding region 178 and 142 nt in length, respectively. In addition to four predicted structural proteins, the polyprotein shows other non-structural proteins typical of picornaviruses, such as an RNA helicase , a chymotrypsin- like protease and an RNA-dependent RNA polymerase . The smallest structural protein typical of picornaviruses, VP4, has not yet been detected in the virion. According to sequence comparisons it is very closely related to the wing deformity virus (DWV) and its subtype Kakugo virus .
Isolates
Various isolates were found as subtypes , for example in Europe the Rothamsted bagbrood virus (SBV-UK, isolated in Rothamsted Research ) and the Chinese isolates (CSBV) CSBV-LN and CSBV-GZ. The isolates differ slightly in genome length and in some amino acid deletions .
↑ Ma Mingxiao et al .: Molecular and Biological Characterization of Chinese Sacbrood Virus LN Isolate . Comp. Funct. Genomics (2011), PMC 3061217 (free full text), doi : 10.1155 / 2011/409386 .
literature
YP Chen et al .: Genus Iflavirus . In: * AMQ King, MJ Adams, EB Carstens, EJ Lefkowitz (eds.): Virus Taxonomy. Ninth Report of the International Committee on Taxonomy of Viruses. Amsterdam 2012, ISBN 978-0-12-384684-6 , p. 848.
