Salvador Moncada

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Sir Salvador Moncada (born December 3, 1944 in Tegucigalpa , Honduras ) is a British-Honduran pharmacologist .

Life

Moncada graduated from the Universidad de El Salvador with a degree in medicine, which he began in 1962 . At the University of London , he obtained a Ph.D. in 1973 from John Robert Vane. in Pharmacology and 1983 in General Sciences ( D.Sc. ). Moncada worked as a lecturer at the universities of El Salvador and Honduras, from 1974 as an assistant professor at the University of Honduras. From 1975 he worked in pharmaceutical research at Wellcome , in particular he did research on prostaglandins . In 1986 he took over the management of the research laboratories there. From 1995 to 2012 he headed the Wolfson Institute for Biomedical Research at University College London . He was succeeded by William D Richardson. Moncada is married to Marie-Esmeralda of Belgium , a daughter of the Princess of Réthy and a member of the Belgian royal family. The couple have two children. In 2010, Moncada, now also a British citizen, was raised to the British nobility by Queen Elizabeth II as a Knight Bachelor in recognition of his academic achievements . Today Moncada is Director of the Institute of Cancer Sciences at the University of Manchester .

Act

Moncada was able to make fundamental contributions to the understanding of the body's own signal transmission with applications in pharmacology . His research areas are vasoactive substances , arachidonic acid metabolism and nitric oxide (NO). He was able to identify the latter as endothelium-derived relaxing factor (EDRF), which laid the foundation for the use of glycerol trinitrate in the treatment of coronary artery disease .

Moncada discovered that mammalian vessel walls synthesize nitric oxide from L-arginine . He was able to explain the importance of this metabolic pathway as a universal mechanism of signal transduction for the regulator of various cell functions. Moncada played an important role in the discovery of thromboxane synthase and prostacyclin .

The award of the Nobel Prize in Physiology or Medicine in 1998 for research into the relationship between L-arginine and NO to Robert F. Furchgott , Louis J. Ignarro and Ferid Murad , ignoring Moncada, met with incomprehension among parts of the scientific community.

Awards (selection)

literature

Web links

Commons : Salvador Moncada  - Collection of images, videos and audio files

Individual evidence

  1. ↑ About Us. In: ucl.ac.uk. July 27, 2015, accessed January 23, 2016 .
  2. ↑ Descendants of Leopold I, King of The Belgians ( Memento from July 24, 2011 in the Internet Archive )
  3. ^ New Year's Honors for UCL staff
  4. ↑ István Hargittai: Salvador Moncada. In: Candid Science II. Conversations with Famous Biomedical Scientists. World Scientific Publishing 2002 ISBN 1-86094-280-6 p. 565
  5. ^ Fellows of the Royal Society at royalsociety.org; Retrieved June 20, 2011
  6. ^ Prince of Asturia Awards. Technical & Scientific Research 1990 at fpa.es; Retrieved December 3, 2010
  7. ^ Salvador Moncada (1944), United Kingdom - KNAW. In: knaw.nl. Retrieved January 23, 2016 .
  8. ^ A b Salvador Moncada at the Academia Europaea (ae-info.org); Retrieved July 16, 2011
  9. ^ New Year Honors — United Kingdom (PDF, 81 kB) at london-gazette.co.uk; accessed on May 12, 2019.
  10. ^ Ernst Jung Medal for Medicine in Gold 2013: Prof. Sir Salvador E. Moncada MD PhD at the Jung Foundation (jung-stiftung.de); accessed on May 12, 2019.
personal data
SURNAME Moncada, Salvador
ALTERNATIVE NAMES Moncada, Salvador E .; Moncada, Salvador Enrique
BRIEF DESCRIPTION British-Honduran pharmacologist
DATE OF BIRTH December 3, 1944
PLACE OF BIRTH Tegucigalpa , Honduras