Yellow orange S

Structural formula
General
Surname	Yellow orange S
other names	Disodium 6-hydroxy-5 - [( E ) - (4-sulfonatophenyl) diazenyl] -2-naphthalenesulfonate ( IUPAC ); CI Food Yellow 3; CI 15985; E 110 ; Sunset yellow FCF; FD & C Yellow No. 6th; Sunset yellow;
Molecular formula	C 16 H 10 N 2 Na 2 O 7 S 2
External identifiers / databases
EC number	220-491-7
ECHA InfoCard	100.018.629
PubChem	17730
ChemSpider	11431290
Wikidata	Q410095
properties
Molar mass	452.36 g mol −1
Physical state	firmly
density	0.617 g cm −3
Melting point	> 300 ° C
boiling point	836.6 ° C
solubility	4 g l −1 in water at 26 ° C; bad in ethanol ;
safety instructions
GHS labeling of hazardous substances	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
Toxicological data	> 10000 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Yellow orange S , also Sunset Yellow FCF , is an artificial acid and lightfast food coloring from the class of azo coloring agents . As a food additive E 110, it is preferably used in ready-made foods such as citrus fruit yoghurt or in yellowish cheeses. It is classified as an allergen (asthma, skin reactions), which particularly affects people with aspirin intolerance. Kidney tumors have also occurred in animal experiments.

properties

The absorption maximum is at 482 nm .

use

Yellow Orange-S is used as a coloring agent in food and pharmaceuticals. Among other things, it is used in:

Asia rice and peanut snacks
Bubble teas
Fruit gums
jelly
some potassium substitution drugs
Salmon substitute
Medications such as ACE inhibitors
Vetmedin (medicine for dogs with heart disease)
Aperol
Coloring of antiseptics for skin disinfection to identify the areas that have already been treated

Sunset yellow (E110) may cause allergic reactions to ACE inhibitors, including asthma.

Legal situation

Since July 21, 2010, foods containing the azo dye must be labeled in the European Union with a warning, the text of which reads: "May impair activity and attention in children".

On June 1, 2013, the permitted daily dose was temporarily reduced from a maximum of 2.5 mg / kg body weight to 1 mg / kg body weight. In view of the new data available, a permitted daily dose of 4 mg / kg body weight was set on May 15, 2014.

Individual evidence

↑ Entry on E 110: Sunset Yellow FCF / Orange Yellow S in the European database on food additives, accessed on June 16, 2020.
↑ ^a ^b ^c ^d ^e ^f ^g Data sheet Sunset Yellow FCF from Sigma-Aldrich , accessed on November 18, 2019 ( PDF ).
^ Entry on yellow orange S. In: Römpp Online . Georg Thieme Verlag, accessed on November 12, 2014.
↑ Entry on disodium 6-hydroxy-5 - ((4-sulfonatophenyl) azo) naphthalene-2-sulfonate in the GESTIS substance database of the IFA , accessed on November 18, 2019 (JavaScript required)
↑ E110 - Gelborange S. In: enius.de. Retrieved July 28, 2017 .
↑ Hans-Harald Sedlacek: Oncology - the human tumor diseases: origin, defense and treatment options . de Gruyter, Berlin / Boston 2013, ISBN 3-11-025594-4 , p. 259 ( limited preview in Google Book search).
↑ ^a ^b Rami Q. (No longer available online.) In: Open Drug Database. Archived from the original on July 28, 2017 ; accessed on July 28, 2017 .
↑ Entry on Vetmedin at Vetpharm, accessed on July 28, 2017.
↑ ChloraPrep colored 20 mg / ml + 0.7 ml / ml solution for use on the skin. (PDF; 20 kB) at Pharmazie.com, accessed on August 25, 2011.
↑ Reinhard Wolff: Brightly colored is unhealthy. In: The daily newspaper . July 18, 2010, accessed July 28, 2017 .
^ Assessment of the results of the study by McCann et al. (2007) on the effect of some colors and sodium benzoate on children's behavior - Scientific Opinion of the Panel on Food Additives, Flavors, Processing Aids and Food Contact Materials (AFC) . In: EFSA Journal . tape 6 , no. 3 , 2008, p. 660 , doi : 10.2903 / j.efsa.2008.660 .
↑ Gisela Horlemann: Controversial dyes in food are drastically restricted. (No longer available online.) In: Food Monitor. May 8, 2013, archived from the original on December 22, 2015 ; accessed on December 14, 2015 .
↑ Yellow orange S: EFSA sets ADI. EFSA, July 15, 2014, accessed July 18, 2014 .

[E-Nummer110-1] Entry on E 110: Sunset Yellow FCF / Orange Yellow S in the European database on food additives, accessed on June 16, 2020.

[SIGMA-2] ↑ ^a ^b ^c ^d ^e ^f ^g Data sheet Sunset Yellow FCF from Sigma-Aldrich , accessed on November 18, 2019 ( PDF ).

[roempp-3] Entry on yellow orange S. In: Römpp Online . Georg Thieme Verlag, accessed on November 12, 2014.

[Gestis-4] Entry on disodium 6-hydroxy-5 - ((4-sulfonatophenyl) azo) naphthalene-2-sulfonate in the GESTIS substance database of the IFA , accessed on November 18, 2019 (JavaScript required)

[5] E110 - Gelborange S. In: enius.de. Retrieved July 28, 2017 .

[6] Hans-Harald Sedlacek: Oncology - the human tumor diseases: origin, defense and treatment options . de Gruyter, Berlin / Boston 2013, ISBN 3-11-025594-4 , p. 259 ( limited preview in Google Book search).

[ODDB-7] Rami Q. (No longer available online.) In: Open Drug Database. Archived from the original on July 28, 2017 ; accessed on July 28, 2017 .

[8] Entry on Vetmedin at Vetpharm, accessed on July 28, 2017.

[9] ChloraPrep colored 20 mg / ml + 0.7 ml / ml solution for use on the skin. (PDF; 20 kB) at Pharmazie.com, accessed on August 25, 2011.

[Tageszeitung-10] Reinhard Wolff: Brightly colored is unhealthy. In: The daily newspaper . July 18, 2010, accessed July 28, 2017 .

[11] Assessment of the results of the study by McCann et al. (2007) on the effect of some colors and sodium benzoate on children's behavior - Scientific Opinion of the Panel on Food Additives, Flavors, Processing Aids and Food Contact Materials (AFC) . In: EFSA Journal . tape 6 , no. 3 , 2008, p. 660 , doi : 10.2903 / j.efsa.2008.660 .

[12] Gisela Horlemann: Controversial dyes in food are drastically restricted. (No longer available online.) In: Food Monitor. May 8, 2013, archived from the original on December 22, 2015 ; accessed on December 14, 2015 .

[13] Yellow orange S: EFSA sets ADI. EFSA, July 15, 2014, accessed July 18, 2014 .