Tobias B. Huber

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Tobias B. Huber (born August 25, 1971 in Waldkirch ) is a German nephrologist and internist . He is a university professor, director and head of the III. Medical clinic at the University Medical Center Hamburg-Eppendorf. Before that he was head of the Chronic Kidney Disease Department at the University Medical Center Freiburg . Huber is internationally known for his scientific work on the molecular structure and function of the kidney filter. He is the grandson of the botanist Bruno Huber and great-grandson of the historian Alfons Huber and is related to the cell biologist Lukas Huber .

Life

Huber studied medicine in Freiburg , Vienna and Tampa (USA) (1992–1999). After completing his doctorate at the Physiological Institute in Freiburg, he worked from 1999 to 2003 as an assistant doctor in the nephrological department of the Freiburg University Medical Center. From 2003 to 2006 he was an Emmy Noether fellow of the Deutsche Forschungsgemeinschaft at the Department of Immunology and Pathology at Washington University in St. Louis (USA) . After completing his habilitation in 2007 and being recognized as a specialist in internal medicine , Huber headed an Emmy Noether research group in Freiburg. In 2012 he was accepted into the Heisenberg program and has held a W3 Heisenberg professorship for nephrology in Freiburg since 2013. From 2015 to 2017 Huber was Deputy Medical Director of the Clinic for Internal Medicine IV for Nephrology and General Medicine and Head of the Department for Chronic Kidney Diseases at the University Medical Center Freiburg. He was also co-director of the Center for Biosystems Analysis (ZBSA). Since April 2017, Huber has been director and head of the III Medical Clinic at the University Medical Center Hamburg-Eppendorf .

Scientific contribution

Huber and his team have made important contributions to understanding the function and diseases of the kidney . The focus of research is on complex signal processes in the development, maintenance and disease progression of the kidney. Huber's team identified several molecular mechanisms responsible for kidney failure, maintenance, aging, and disease.

On May 13, 2020, The New England Journal of Medicine published an online study by Huber et al. They quantified the viral load of 22 deceased in tissue samples from seven organs (including the kidneys, lungs, throat, heart, liver and brain). Up to 50% of COVID-19 patients experience acute kidney failure . The study's findings explain why COVID-19 often causes kidney damage. Symptom-free Covid-19 infected people should therefore also have their urine tested ; the test only costs a few cents. The earlier kidney problems are detected, the better medical professionals can avoid permanent damage.

Memberships in scientific associations

Huber is a member of numerous scientific associations. These include the German Society for Nephrology , the American Society of Nephrology , the German Society for Internal Medicine and the American Society for Clinical Investigation .

Honors and awards (selection)

Huber has received several international awards as well as national and international prizes for kidney research. In addition to a research grant from the German Kidney Foundation , which he received in 2002, the German Society for Nephrology awarded him the Carl Ludwig Prize (2004), the Hans-U.-Zollinger Research Prize (2009) and the Franz Volhard Prize (2010 ). In 2012 the American Society of Nephrology and the American Heart Association presented him with the prestigious Young Investigator Award . In 2014 Huber received a Consolidator Grant from the European Research Council (ERC) for research into diabetic kidney diseases . In 2014 Huber was inducted into the American Society for Clinical Investigation . Since 2015 he has been an Internal Senior Fellow of the FRIAS-Freiburg Institute for Advanced Studies .

Publications (selection)

Web links

Individual evidence

  1. ↑ a b III. Medical clinic at the University Medical Center Hamburg-Eppendorf
  2. ↑ Clinic for Internal Medicine IV for Nephrology and General Medicine, University Hospital Freiburg ( Memento of the original from July 1, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.uniklinik-freiburg.de
  3. ↑ a b Research Prize for Tobias Huber In: badische-zeitung.de , September 28, 2009, accessed on December 6, 2017.
  4. ^ A b c Young Investigator Attains Recognition for Podocyte Research In: kidneynews.org.Retrieved December 6, 2017.
  5. ↑ a b Prof. Dr. Tobias B. Huber - Freiburg Institute for Advanced Studies - FRIAS In: frias.uni-freiburg.de, accessed on December 6, 2017.
  6. ↑ Department of Internal Medicine IV for Nephrology and General Medicine, University Medical Center Freiburg ( Memento from July 1, 2016 in the Internet Archive )
  7. ↑ Center for Biosystems Analysis, University Hospital Freiburg - Huberlab ( Memento of the original from May 31, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.tbhuber.org
  8. ↑ Huber, TB, Schermer, B., Muller, RU, Hohne, M., Bartram, M., Calixto, A., Hagmann, H., Reinhardt, C., Koos, F., Kunzelmann, K., Shirokova , E., Krautwurst, D., Harteneck, C., Simons, M., Pavenstadt, H., Kerjaschki, D., Thiele, C., Walz, G., Chalfie, M., and Benzing, T. 2006 . Podocin and MEC-2 bind cholesterol to regulate the activity of ion channels associated . Proc Natl Acad Sci U S A 103: 17079-86. doi: 10.1073 / pnas.0607465103 .
  9. ↑ Huber, TB, Kwoh, C., Wu, H., Asanuma, K., Godel, M., Hartleben, B., Blumer, KJ, Miner, JH, Mundel, P., and Shaw, AS 2006. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin . J Clin Invest 116: 1337-45. doi: 10.1172 / jci27400 .
  10. ↑ Grahammer, F., Schell, C., and Huber, TB 2013. The podocyte slit diaphragm - from a thin gray line to a complex signaling hub . Nat Rev Nephrol 9: 587-98. doi: 10.1038 / nrneph.2013.169 .
  11. ↑ Grahammer, F., Nesterov, V., Ahmed, A., Steinhardt, F., Sandner, L., Arnold, F., Cordts, T., Negrea, S., Bertog, M., Ruegg, MA, Hall, MN, Walz, G., Korbmacher, C., Artunc, F., and Huber, TB 2016. mTORC2 critically regulates renal potassium handling . J Clin Invest doi: 10.1172 / jci80304 .
  12. ↑ When the sugar kills the kidneys In: pr.uni-freiburg.de , accessed on December 6, 2017. doi: 10.1172 / JCI44774
  13. ↑ Hartleben, B., Godel, M., Meyer-Schwesinger, C., Liu, S., Ulrich, T., Kobler, S., Wiech, T., Grahammer, F., Arnold, SJ, Lindenmeyer, MT , Cohen, CD, Pavenstadt, H., Kerjaschki, D., Mizushima, N., Shaw, AS, Walz, G., and Huber, TB 2010. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice . Journal of Clinical Investigation 120: 1084-96. doi: 10.1172 / jci39492 .
  14. ↑ Godel, M., Hartleben, B., Herbach, N., Liu, S., Zschiedrich, S., Lu, S., Debreczeni-Mor, A., Lindenmeyer, MT, Rastaldi, MP, Hartleben, G. , Wiech, T., Fornoni, A., Nelson, RG, Kretzler, M., Wanke, R., Pavenstadt, H., Kerjaschki, D., Cohen, CD, Hall, MN, Ruegg, MA, Inoki, K ., Walz, G., and Huber, TB 2011. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice . In Invest 121: 2197-209. doi: 10.1172 / jci44774 .
  15. ↑ Grahammer, F., Schell, C., and Huber, TB 2013. The podocyte slit diaphragm - from a thin gray line to a complex signaling hub . Nat Rev Nephrol 9: 587-98. doi: 10.1038 / nrneph.2013.169 .
  16. ↑ a b BIOSS Member Wins Young Investigator Award 2012 In: bioss.uni-freiburg.de , accessed on December 6, 2017.
  17. ↑ Multiorgan and Renal Tropism of SARS-CoV-2 , German summary see aerzteblatt.de (May 18, 2020)
  18. ↑ FAZ.net June 8, 2020: Interview with Prof. Christoph Wanner
  19. ^ Prize winners - German Society for Nephrology In: dgfn.eu , accessed on December 6, 2017.
  20. ↑ Awarding of the Hans-U.-Zollinger Research Prize 2009 In: aerzteblatt.de , accessed on December 6, 2017.
  21. ↑ Awarding of the science prizes of the DGfN and the research grants of the German Kidney Foundation In: innovations-report.de , accessed on December 6, 2017.
  22. ↑ Call for applications ASN Young Investigator Award 2012 In: aerzteblatt.de accessed on December 6, 2017.
  23. ↑ EU sponsorship award for Tobias Huber from Waldkirch In: badische-zeitung.de , February 28, 2014, accessed on December 6, 2017.
  24. ↑ Tobias Huber, foreign member of The American Society for Clinical Investigation (ASCI) In: the-asci.org , accessed on December 6, 2017.
personal data
SURNAME Huber, Tobias
ALTERNATIVE NAMES Huber, Tobias B.
BRIEF DESCRIPTION German nephrologist
DATE OF BIRTH August 25, 1971
PLACE OF BIRTH Waldkirch