Lukas Huber (doctor)

Lukas A. Huber (2013)

Lukas Alfons Huber (born July 4, 1961 in Vienna ) is an Austrian doctor, cell biologist and university professor at the Medical University of Innsbruck . He is the scientific director of the Austrian Drug Screening Institute (ADSI) and the Center for Personalized Cancer Medicine Oncotyrol in Innsbruck .

Live and act

Huber comes from a family of doctors from Schwaz in Tyrol and after attending the humanistic episcopal high school Paulinum, he studied medicine in Innsbruck. His first and important teacher was Georg Wick, with whom he received his doctorate in 1990 on the "Immunoregulatory Role of Lipoproteins". He then went to Heidelberg as a PostDoc with Kai Simons at the European Molecular Biology Laboratory (EMBL), where he investigated the role of small GTP- binding proteins ( Rab proteins ) in polarized protein transport in epithelia and neurons . Three years later he took a position as Maître-Assistant at the University of Geneva and worked in Jean Gruenberg's laboratory on the role of motor proteins in endocytosis . He returned to Austria in 1996. At first he headed his own working group at the Research Institute for Molecular Pathology in Vienna with a focus on signal transduction at the endosome , then he accepted the call to the Medical University of Innsbruck, where he has been full professor and director of the department of cell biology since 2002. He was and is active in numerous offices and functions at the Medical University of Innsbruck, including as founding director of the Biozentrum, as a member of the Senate, member of the honorary committee, head of the research infrastructure commission, on the board of the Integrated Research and Therapy Center (ITFZ) and as chairman of the Ilse and Helmut Wachter Foundation. His thematic focus in national and international large-scale and joint projects are proteomics , molecular and cell biological cancer research as well as translational oncology and drug screening. He headed the Austrian Proteomics Platform APP as part of the national genome research program GEN-AU as well as the Collaborative Research Center 021 “Cell proliferation and Cell death in tumors” of the FWF Fund for the Promotion of Scientific Research . He initiated and coordinated the international cancer research project Growthstop on programmed cell death in tumors, which took place in the 6th research framework program of the European Commission and was project leader in the international myeloma research project OPTATIO of the 7th European research framework program. Since 2009 he has been the scientific director of the Center for Personalized Cancer Research Oncotyrol, a COMET center (K1) of the Austrian Research Promotion Agency (FFG). Huber is committed to the FWF doctoral program Molecular Cell Biology and Oncology MCBO for young scientists.

After declining an offer from the University of Dublin , Huber founded the Austrian Drug Screening Institute (ADSI) in Innsbruck together with Günther Bonn in 2012 , which the two researchers jointly manage. The ADSI researches plant extracts in particular for their drug effects and uses mass spectrometry and automated drug screening on living cell cultures.

Lukas Huber is Senior Editor of the journals Proteomics, Proteomics Clinical Applications and FEBS Letters, Current Signal Transduction Therapy and Review Editor for Frontiers Cell and Developmental Biology and is co-editor of a textbook on small GTPases . He was and is active in various scientific advisory bodies, among others for the German Research Foundation (DFG), the German Federal Ministry of Education and Research and for the Bavarian genome research network Baygene.

research

Lukas Huber's research results have been published in more than 150 scientific articles which have been cited more than ten thousand times. His basic research has provided important insights in the field of signal transduction . Lukas Huber uses cell biological and proteomic methods such as tandem affinity purification coupled with mass spectrometry . His contributions to research into microvillus inclusion disease, a congenital, life-threatening diarrheal disease in babies and young children, are of particular clinical importance . Huber's research also contributes to a fundamental understanding of immunology , especially in the collaboration with the Innsbruck immunodermatologist Nikolaus Romani, on cancer development ( carcinogenesis ), cell growth and migration ( cell migration ) and offers starting points for drug development . Huber's particular interest is in endosomal signal protein complexes. In order to be able to react correctly to their environment, cells have to transmit external information into the cell nucleus . Since only a limited number of signal transmission paths are available for this, the internal communication must be precisely controlled in terms of location and time. Endosomes are small membrane-covered cell organelles that bring signal proteins together in the right combinations and monitor the duration of signal transmission. The endosomal signal transmission is one of the decisive factors for the fact that the communication processes in the cell run in an orderly manner and that cell growth and cell death are precisely regulated. Huber is researching the tasks of scaffold and adapter proteins, in particular the LAMTOR complex, an association of seven currently known regulatory proteins. This complex coordinates cell division, cell growth, cell death and cell migration by binding and controlling the signaling pathways MAPK and mTorC.

Awards and honors

• 1990 Hoechst Prize
• 1995 Johnson and Johnson Focused Giving Grant
• 1995 Research Prize German Society for Cell Biology
• 1996 Dr. Johannes Tuba Prize for Aging Research
• 2007 CAST Technology Award
• 2010 Austrian representative and member of the steering committee of the European Science Foundation (ESF) program Frontiers of Functional Genomics
• 2012 Appointment to University College Dublin as Professor and Director Systems Pharmacology - declined
• 2013 Austrian representative IARC Scientific Council ( WHO )
• 2014 Vice President Austrian Society for Molecular Biosciences and Biotechnology (ÖGMBT)
• 2015 Member of the Advisory Board of the Max Planck Institute for Infection Research Berlin

Web links

• Biocenter Report 2008 online
• Biocenter Report 2010 online
• Biocenter Report 2012 online
• Growthstop website of the European Commission, Community Research and Development Information Service CORDIS
• Georg Wicks memories of his PhD student Huber , p. 5, p. 7
• Laborwelt special issue Clinical Proteomics, No. 4 2005, article "Qualitative and quantitative proteomics" p. 26

Individual evidence

1. ^ Curriculum vitae Lukas Huber website of the Medical University of Innsbruck. Retrieved January 4, 2016.
2. ↑ Huber Scientific Director of the Austrian Drug Screening Institute ( Memento of the original from December 28, 2015 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Website of the Austrian Drug Screening Institute. Retrieved January 4, 2016. 
3. ↑ Lukas Huber Chief Scientific Officer of Oncotyrol ( Memento of the original from December 28, 2015 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Oncotyrol website: governance structure. Retrieved January 4, 2016. 
4. ↑ return with ambitious plans Newsbeitrag to appeal Hubers of 28 August 2002; University of Innsbruck website. Retrieved January 4, 2016
5. ↑ Jean Gruenberg working group ; Website of the University of Geneva, Department of Biochemistry, Jean Gruenberg Working Group. Retrieved January 7, 2016.
6. ↑ Former group leader at the Research Institute for Molecular Pathology ; Website of the Research Institute for Molecular Pathology. Retrieved January 4, 2016
7. ^ Division for Cell Biology at the Medical University of Innsbruck ; Website of the Medical University of Innsbruck. Retrieved January 4, 2016.
8. ^ "The West wants to keep up with the competition" Website of the daily newspaper Der Standard , Interview by Klaus Taschwer with Lukas Huber. Article dated January 29, 2008. Retrieved January 4, 2016.
9. ↑ Composition of the Infrastructure Commission of the Medical University of Innsbruck ; Website of the Medical University of Innsbruck. Retrieved January 4, 2016.
10. ^ Board of the Integrated Research and Therapy Center IFTZ website of the Medical University of Innsbruck. Retrieved January 4, 2016.
11. ↑ Lukas Huber Chairman of the Ilse & Helmut Wachter Foundation ( Memento of the original from March 4, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Website of the Ilse & Helmut Wachter Foundation. Retrieved January 4, 2016. 
12. ↑ "On the trail of the next secrets of life" Article in the standard of May 31, 2003 by Andreas Ferien. Retrieved January 4, 2016.
13. ^ Journal of Spectrum Onkology special edition personalized medicine, article by Lukas Huber "Translational research for personalized medicine" pp. 32–34, Medmedia Verlag ISSN  2223-0645 . Retrieved on January 4, 2016. ( online ( memento of the original from December 28, 2015 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this note. ) 
14. ^ Journal of Spectrum Onkology, Huber's article: “Early Drug Screening”, October 16, 2014, pp. 97–99, Medmedia Verlag. Accessed January 4, 2016. ( online )
15. ↑ “Der Standard” of March 14, 2003, “Proteomics Platform Founded” ( online ). Retrieved January 4, 2016.
16. ^ Website of the University of Innsbruck: "New special research area approved" of October 9, 2003 and "Life Science location further strengthened" of December 9, 2010 to extend the SFB. Accessed on January 4, 2016.
17. ↑ "The Standard" for the EU FP6 project Growthstop "Therapy beyond the lock-and-key principle" by Andreas Holiday May 26, 2010 p. 22 ( online ). Retrieved January 4, 2016.
18. ↑ OPTATIO project on the website of the European Commission Community Research and Development Information Service (CORDIS) . Accessed January 4, 2016.
19. ^ Website of the Medical University of Innsbruck on Huber's appointment as Chief Scientific Officer of the Oncotyrol Cancer Research Center.Retrieved January 4, 2016.
20. ^ Website of the international graduate program Molecular Cell Biology and Oncology. Accessed January 4, 2016.
21. ↑ Chemiereport, publisher Josef Brodacz, "More than hits and leads" to the start of the Austrian Institute of Drug Screening George Sachs, December 28, 2012 p 44f ( online )
22. ↑ The standard at the start of the Austrian Drug Screening Institute on November 28, 2012. “Getting the valuable out of the plant” by Jutta Berger ( online )
23. ↑ Die Presse: "What Plants Can Do for Pharmacy" on the Austrian Drug Screening Institute from October 17, 2015 by Veronika Schmidt ( online )
24. ↑ Die Presse: “Das Plattenhotel im Zauberkasten” from October 17, 2015 on the automatic screening of human cell cultures in the Austrian Drug Screening Institute by Veronika Schmidt ( online )
25. ↑ Website of the specialist journal Proteomics Editorial Board ( Memento of the original from December 28, 2015 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. 
26. ↑ Website of the professional journal Proteomics Clinical Applications Editorial Board ( Memento of the original from December 28, 2015 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. 
27. ↑ Website of the trade journal FEBS letters Editorial Board  ( page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.  
28. ^ Website of the journal Current Signal Transduction Therapy Editorial Board
29. ^ Website of the journal Frontiers in Cell and Developmental Biology
30. ↑ Web link to the specialist book "Guidebook to the Small GTPases, edited by Marino Zerial & Lukas A. Huber, Sambrook & Tooze Publications , ISBN 978-0-19-859944-9
31. ↑ website of BayGene organizational structure
32. ^ Pubmed entries Huber
33. ↑ Citation entries by Lukas Huber
34. ↑ Der Standard: "Mechanism of signal transmission in cells clarified", December 6, 2002 ( online )
35. ↑ Overview of research content and thematically selected publications on the website of the Division of Cell Biology
36. ↑ Website of the Medical University of Innsbruck on Lukas Huber's contribution to research into the microvillus inclusion disease on the occasion of a current publication in the Journal of Cell Biology
37. ↑ Website of the Medical University of Innsbruck on the results of the collaboration between Nikolaus Romani and Lukas Huber
38. ↑ Der Standard: "Bright spot for leukemia patients", October 23, 2014 ( online )
39. ↑ The press on joint research with Giulio Superti-Furga ( online )
40. ↑ Website of the Medical University of Innsbruck on Huber's new research results on the subject of cell migration
41. ^ Die Presse: "Cancer Therapy: Blocking Signals" by Jürgen Langenbach, July 27, 2004 ( online )
42. ↑ Exemplary review article D. Teis, Huber LA "The odd couple: signal transduction and endocytosis" (2003) Cell and Molecular Life Sciences 60 (2020–2033), for further original literature see section "Literature"
43. ^ Website of the University of Innsbruck on the CAST Technology Award [1]
44. ^ Website of the European Science Foundation
45. ↑ Website of the Medical University of Innsbruck: "Top researcher Lukas Huber will remain Tyrol as a life sciences location"
46. ↑ Biosketch Austrian representative IARC Scientific Council
47. ^ Website of the Austrian Society for Molecular Biosciences and Biotechnology - Board of Directors
48. ^ Website of the Max Planck Institute for Infection Research