Estriol

Structural formula
General
Surname	Estriol
other names	Estra-1,3,5 (10) -triene-3,16 α , 17 β -triol 16 α - hydroxy -17 β -estradiol Estriol
Molecular formula	C 18 H 24 O 3
Brief description	Colorless crystals
External identifiers / databases
CAS number 50-27-1 EC number 200-022-2 ECHA InfoCard 100,000,021 PubChem 5756 DrugBank DB04573 Wikidata Q409721
Drug information
ATC code	G03 CA03 G03 CC06 G03 CD01
Drug class	Estrogens
properties
Molar mass	288.37 g · mol -1
Physical state	firmly
Melting point	282-285 ° C
solubility	soluble in organic solvents and vegetable oils, practically insoluble in water
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances danger H and P phrases H: 351-360 P: 201-281-308 + 313
Toxicological data	> 2000 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Estriol (E ₃ ), also known as estriol , is a quantitatively important metabolic product of estradiol and estrone . It has a weak estrogenic effect, about 1/10 that of estradiol. It is formed in the placenta directly or from precursors synthesized by the fetus . Estriol is also produced in adipose tissue by aromatizing the A-ring of androstenedione .

Trade names

Monopreparations

OeKolp (D), Oestro-Gynaedron (D, CH), Ortho-Gynest (D, A, CH), Ovestin (D, A, CH), Xapro (D), Generika (D)

Combination preparations

CycloÖstrogynal (D), Gynoflor (D, A, CH)

Individual evidence

1. ↑ ^{a b c} Entry on estriol. In: Römpp Online . Georg Thieme Verlag, accessed on December 28, 2014.
2. ↑ ^{a b} sheet estriol at Sigma-Aldrich retrieved on October 18, 2016 ( PDF ).
3. ↑ Entry on estriol in the ChemIDplus database of the United States National Library of Medicine (NLM) .