1-bromo-3-chloropropane

from Wikipedia, the free encyclopedia
Structural formula
Structural formula of 1-bromo-3-chloropropane
General
Surname 1-bromo-3-chloropropane
other names
  • 1-chloro-3-bromopropane
  • Trimethylene chlorobromide
  • Trimethylene bromide chloride
  • 3-bromopropyl chloride
Molecular formula C 3 H 6 BrCl
Brief description

colorless liquid with a characteristic odor

External identifiers / databases
CAS number 109-70-6
EC number 203-697-1
ECHA InfoCard 100.003.362
PubChem 8006
ChemSpider 7715
Wikidata Q22829220
properties
Molar mass 157.44 g mol −1
Physical state

liquid

density

1.60 g cm −3

Melting point

−59 ° C

boiling point

143 ° C

Vapor pressure

7.5 hPa (20 ° C)

solubility
Refractive index

1.4855 (20 ° C)

safety instructions
GHS labeling of hazardous substances
06 - Toxic or very toxic

danger

H and P phrases H: 302-331-412
P: 273-304 + 340-308 + 310
Toxicological data

930 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

1-Bromo-3-chloropropane is a chemical compound from the group of aliphatic , saturated halogenated hydrocarbons .

Extraction and presentation

1-Bromo-3-chloropropane can be obtained by the radical addition of hydrogen bromide to allyl chloride .

properties

1-Bromo-3-chloropropane is a flammable, hardly inflammable, colorless liquid with a characteristic odor that is sparingly soluble in water.

use

1-Bromo-3-chloropropane is used in the manufacture of industrial and pharmaceutical substances such as Gemfibrozil and Reproterol . It is also used as a phase separation reagent for the isolation of high quality ribonucleic acid (RNA).

Individual evidence

  1. ↑ a b c d e f g h i j k Entry on 1-bromo-3-chloropropane in the GESTIS substance database of the IFA , accessed on March 22, 2020(JavaScript required) .
  2. ↑ a b c Data sheet 1-Bromo-3-chloropropane, 99% from AlfaAesar, accessed on March 22, 2020 ( PDF )(JavaScript required) .
  3. ^ Wiley-VCH: Ullmann's Fine Chemicals . John Wiley & Sons, 2014, ISBN 978-3-527-68359-8 , pp. 23 ( limited preview in Google Book search).
  4. ^ E. Reinholz, A. Becker, B. Hagenbruch, S. Schäfer, A. Schmitt: Selectivity in Alkylation of Phenols with 1-Bromo-3-chloropropane Using Phase-Transfer Catalysis. In: Synthesis. 1990, 1990, p. 1069, doi : 10.1055 / s-1990-27096 .