4-methylumbelliferone

Structural formula
General
Non-proprietary name	Hymecromon
other names	4-methylumbelliferone β-methylumbelliferone IUPAC : 7-Hydroxy-4-methylcoumarin
Molecular formula	C 10 H 8 O 3
Brief description	white to yellowish crystals
External identifiers / databases
CAS number 90-33-5 EC number 201-986-7 ECHA InfoCard 100.001.806 PubChem 5280567 ChemSpider 4444190 DrugBank DB07118 Wikidata Q904431
Drug information
ATC code	A05 AX02
Drug class	Antispasmodic
properties
Molar mass	176.17 g · mol -1
Physical state	firmly
Melting point	194-195 ° C
pK s value	7.83
solubility	practically insoluble in cold water soluble in glacial acetic acid and methanol
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances Caution H and P phrases H: 315-319-335 P: 261-305 + 351 + 338
Toxicological data	3850 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

4-methylumbelliferone or hymecromone ( INN ) is a methyl - derivative of umbelliferone .

It is used as a medicinal substance (as a choleretic and musculotropic antispasmodic ) and as a light or sunscreen , as it absorbs UV radiation . It is also used in fluorescence analysis. It is often used in the form of esters , which are then cleaved by the esterases . Often used is 4-methylumbelliferyl heptanoate , which is abbreviated to MUH.

Trade names

Monopreparations

Cholspasmin (D), Chol-Spasmoletten (D), Unichol (A)

Individual evidence

1. ↑ HPT Ammon (Ed.): Hunnius Pharmaceutical Dictionary . 9th edition. Walter de Gruyter, Berlin a. New York 2004, pp. 752-753.
2. ↑ ^{a b c d} Entry on Hymecromon. In: Römpp Online . Georg Thieme Verlag, accessed on May 1, 2014.
3. ↑ ^{a b} Data sheet 4-Methylumbelliferone from Sigma-Aldrich , accessed on April 4, 2011 ( PDF ).
4. ↑ Data sheet HYMECROMONE CRS (PDF) at EDQM , accessed on July 31, 2008.
5. ↑ Red List, as of August 2009.
6. ↑ AGES-PharmMed, as of August 2009.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !