Potassium antimonyl tartrate

Structural formula
General
Surname	Potassium antimonyl tartrate
other names	Emetic tartar; Potassium antimony (III) oxide tartrate; Antimonyl potassium tartrate; Antimonium tartaricum; Tartarus stibiatus; Tartarus emeticus;
Molecular formula	K 2 Sb 2 C 8 H 4 O 12 · 3 H 2 O
Brief description	colorless, sweet-tasting crystals
External identifiers / databases
EC number	608-190-2
ECHA InfoCard	100.116.333
PubChem	16682736
ChemSpider	17214979
Wikidata	Q423129
properties
Molar mass	667.85 g mol −1
Physical state	firmly
density	2.6 g cm −3
Melting point	100 ° C (water release)
solubility	moderate in water (55 g l −1 ); insoluble in ethanol;
safety instructions
H and P phrases	H: 302 + 332-411
	P: 273
MAK	not specified because it is carcinogenic
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Potassium antimonyl tartrate , and tartar emetic (also briefly tartrate or Tartarus called), is a harmful, especially nausea exciting acting chemical compound . It is obtained by saturating purified tartar with antimony oxide and forms colorless, transparent, shiny crystals that soon become opaque and white in the air. It is a salt of tartaric acid .

use

500 mg of tartar emetic

Potassium antimonyl tartrate used to be administered in doses of 20–30 mg as an emetic , which causes nausea and vomiting about 10 minutes after ingestion. In the digestive tract , it stimulates enterochromaffin cells to secrete serotonin , which in turn induces vomiting via 5-hydroxytryptamine type 3 receptors .

A well-known remedy was an emetic wine ( aqua benedicta rulandi or "Rulandswasser" after Martin Ruland the Elder ) prepared on the basis of potassium antimonyl tartrate (formerly known as Tartarus stibiatus ), which was found in pharmacopoeias until the 19th century.

In the textile and leather industry, tartarine is used as a pickling agent.

Individual evidence

↑ ^a ^b Entry on Brechweinstein. In: Römpp Online . Georg Thieme Verlag, accessed on December 22, 2014.
↑ ^a ^b ^c ^d ^e ^f Entry on potassium antimonyl tartrate in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .
↑ Not explicitly listed in Regulation (EC) No. 1272/2008 (CLP) , but with the specified labeling it falls under the group entry antimony compounds, with the exception of the tetroxide (Sb2O4), pentoxide (Sb2O5), trisulphide (Sb2S3), pentasulphide (Sb2S5) and those specified elsewhere in this Annex in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Wendy Macías Konstantopoulos, Michele Burns Ewald, Daniel S. Pratt: Case 22-2012: A 34-Year-Old Man with Intractable Vomiting after Ingestion of an Unknown Substance. In: New England Journal of Medicine. 367, 2012, pp. 259-268.
↑ Axel W. Bauer : Therapeutics, Therapy Methods. In: Werner E. Gerabek , Bernhard D. Haage, Gundolf Keil , Wolfgang Wegner (eds.): Enzyklopädie Medizingeschichte. De Gruyter, Berlin / New York 2005, ISBN 3-11-015714-4 , pp. 1388-1393; here: p. 1389.
↑ Robley Dunglison: Medical lexicon: A Dictionary of Medical Science. Blanchard & Lea, Philadelphia 1856, p. 906 ( limited preview in Google Book search).
^ Louis Posner: Handbook of clinical drug theory. Hirschwald, Berlin 1866, p. 517 ( limited preview in the Google book search).

[roempp-1] Entry on Brechweinstein. In: Römpp Online . Georg Thieme Verlag, accessed on December 22, 2014.

[GESTIS-2] ↑ ^a ^b ^c ^d ^e ^f Entry on potassium antimonyl tartrate in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .

[CLP_100.240.780-3] Not explicitly listed in Regulation (EC) No. 1272/2008 (CLP) , but with the specified labeling it falls under the group entry antimony compounds, with the exception of the tetroxide (Sb2O4), pentoxide (Sb2O5), trisulphide (Sb2S3), pentasulphide (Sb2S5) and those specified elsewhere in this Annex in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[4] Wendy Macías Konstantopoulos, Michele Burns Ewald, Daniel S. Pratt: Case 22-2012: A 34-Year-Old Man with Intractable Vomiting after Ingestion of an Unknown Substance. In: New England Journal of Medicine. 367, 2012, pp. 259-268.

[5] Axel W. Bauer : Therapeutics, Therapy Methods. In: Werner E. Gerabek , Bernhard D. Haage, Gundolf Keil , Wolfgang Wegner (eds.): Enzyklopädie Medizingeschichte. De Gruyter, Berlin / New York 2005, ISBN 3-11-015714-4 , pp. 1388-1393; here: p. 1389.

[6] Robley Dunglison: Medical lexicon: A Dictionary of Medical Science. Blanchard & Lea, Philadelphia 1856, p. 906 ( limited preview in Google Book search).

[7] Louis Posner: Handbook of clinical drug theory. Hirschwald, Berlin 1866, p. 517 ( limited preview in the Google book search).