Carl H. June

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Carl H. June (2015)

Carl H. June (* 1953 ) is an American immunologist . He teaches at the Pennsylvania Perelman School of Medicine ( University of Pennsylvania ).

Junes research group deals with the mechanisms of the activation of lymphocytes . This concerns in particular the development and testing of new forms of immunotherapy of cancer ( cancer immunotherapy ) or immunotherapy of chronic infections .


June earned a bachelor's degree in biology from the United States Naval Academy in Annapolis , Maryland in 1971 and an MD from Baylor College of Medicine in Houston , Texas in 1979 . 1978/1979 he worked as a research assistant in the immunological research center of the World Health Organization in Geneva . He completed his specialist training in internal medicine between 1979 and 1983 at the National Naval Medical Center in Bethesda , Maryland, but also taught at the Uniformed Services University of the Health Sciences , also in Bethesda. Between 1983 and 1985 he was a postdoctoral fellow with E. Donnell Thomas at the Fred Hutchinson Cancer Research Center in Seattle , Washington .

In 1986 June received his first professorship ( Assistant Professor , 1990 Associate Professor ) for internal medicine at the Uniformed Services University of the Health Sciences , and in 1995 he became a full professor. In 1999 he moved to the University of Pennsylvania School of Medicine as Professor of Molecular and Cellular Engineering (e.g. bioengineering) . In 2001 he switched to a professorship for pathology and laboratory medicine there , and since 2004 he has also held a professorship for internal medicine. Today (as of 2014) June is Head of Translational Research at the Abramson Family Cancer Research Institute at the University of Pennsylvania .


In the area of signal transduction in T cells , the work of Junes' group deals with CD28 and CTLA-4 , more recent work deals with the regulation of the expression of chemokine receptors on T cells. Further studies have examined the role of telomerase expression in the maintenance of telomeres and in the replicative aging of T cells. Novel lentivirus expression systems allow for the first time mechanistic investigations of T-cell costimulation of primary T-cells.

The potential of customized immunotherapy for cancer and HIV infection is the subject of June's research. Thus, techniques have been HIV-CD-4 polyclonal for efficient and large-scale cultivation + - and CD-8 + - helper T-cells developed. Clinical studies investigate adoptive immunotherapies with own (autologous) and foreign (allogeneic) T cells. Several studies use genetically modified T cells. June developed the CART-19 therapy for leukemia.

Awards (selection)

Web links

Individual evidence

  1. ^ William B. Coley Award. In: Retrieved January 28, 2015 .
  2. ^ List of Past AABB Award Recipients. In: Retrieved January 28, 2015 .
  3. Book of Members 1780 – present (PDF, 199 kB) of the American Academy of Arts and Sciences (; accessed on January 28, 2015.
  4. James P. Allison and Carl H. June receive the Paul Ehrlich and Ludwig Darmstaedter Prize 2015. Paul Ehrlich Foundation, January 29, 2015.