Carl H. June

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Carl H. June (2015)

Carl H. June (* 1953 ) is an American immunologist . He teaches at the Pennsylvania Perelman School of Medicine ( University of Pennsylvania ).

Junes research group deals with the mechanisms of the activation of lymphocytes . This concerns in particular the development and testing of new forms of immunotherapy of cancer ( cancer immunotherapy ) or immunotherapy of chronic infections .

Life

June earned a bachelor's degree in biology from the United States Naval Academy in Annapolis , Maryland in 1971 and an MD from Baylor College of Medicine in Houston , Texas in 1979 . 1978/1979 he worked as a research assistant in the immunological research center of the World Health Organization in Geneva . He completed his specialist training in internal medicine between 1979 and 1983 at the National Naval Medical Center in Bethesda , Maryland, but also taught at the Uniformed Services University of the Health Sciences , also in Bethesda. Between 1983 and 1985 he was a postdoctoral fellow with E. Donnell Thomas at the Fred Hutchinson Cancer Research Center in Seattle , Washington .

In 1986 June received his first professorship ( Assistant Professor , 1990 Associate Professor ) for internal medicine at the Uniformed Services University of the Health Sciences , and in 1995 he became a full professor. In 1999 he moved to the University of Pennsylvania School of Medicine as Professor of Molecular and Cellular Engineering (e.g. bioengineering) . In 2001 he switched to a professorship for pathology and laboratory medicine there , and since 2004 he has also held a professorship for internal medicine. Today (as of 2014) June is Head of Translational Research at the Abramson Family Cancer Research Institute at the University of Pennsylvania .

Act

In the area of signal transduction in T cells , the work of Junes' group deals with CD28 and CTLA-4 , more recent work deals with the regulation of the expression of chemokine receptors on T cells. Further studies have examined the role of telomerase expression in the maintenance of telomeres and in the replicative aging of T cells. Novel lentivirus expression systems allow for the first time mechanistic investigations of T-cell costimulation of primary T-cells.

The potential of customized immunotherapy for cancer and HIV infection is the subject of June's research. Thus, techniques have been HIV-CD-4 polyclonal for efficient and large-scale cultivation + - and CD-8 + - helper T-cells developed. Clinical studies investigate adoptive immunotherapies with own (autologous) and foreign (allogeneic) T cells. Several studies use genetically modified T cells. June developed the CART-19 therapy for leukemia.

Awards (selection)

Web links

Individual evidence

  1. ^ William B. Coley Award. In: cancerresearch.org. Retrieved January 28, 2015 .
  2. ^ List of Past AABB Award Recipients. In: aabb.org. Retrieved January 28, 2015 .
  3. ↑ Book of Members 1780 – present (PDF, 199 kB) of the American Academy of Arts and Sciences (amacad.org); accessed on January 28, 2015.
  4. ↑ James P. Allison and Carl H. June receive the Paul Ehrlich and Ludwig Darmstaedter Prize 2015. Paul Ehrlich Foundation, January 29, 2015.
personal data
SURNAME June, Carl H.
ALTERNATIVE NAMES June, Carl
BRIEF DESCRIPTION American immunologist
DATE OF BIRTH 1953