Frank Hölzle

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Frank Hölzle

Frank Hölzle (born February 13, 1968 in Calw ) is a German doctor , dentist and university professor . He is full professor for oral and maxillofacial surgery at the Aachen University Hospital of the RWTH Aachen University and there director of the clinic and polyclinic for oral and maxillofacial surgery. Hölzle is known for his work in the fields of plastic-reconstructive facial surgery with a focus on microsurgery. It is also designated for the treatment of tumor diseases in the head and neck area as well as childhood malformations such as cleft lip and palate .

Life

Hölzle was born in Calw and grew up in the Black Forest. In Calw he attended the Herrmann-Hesse-Gymnasium. From 1989 to 1998, Hölzle studied medicine and dentistry at the Free University of Berlin , Humboldt University in Berlin , University of Glasgow and University College London Medical School. In 1995 he was awarded the title “An anatomical and histological examination of the vascular pedicles of various free transplants”. med is doing his doctorate. From 1995 to 1998 he was an intern and assistant doctor in Berlin . In 1998 he received his doctorate in dentistry with a thesis on the subject of "Conservation methods of allogeneic donor material with special consideration of the experimental glycerol preservation and lyophilization of vessels". From 1999–2000, Hölzle was a research assistant at the Clinic for Oral and Maxillofacial Surgery at the Charité University Clinic , Virchow Clinic Campus . From 2000 to 2007 he worked at the clinic for oral and maxillofacial surgery in the Knappschaftskrankenhaus Bochum-Langendreer of the Ruhr University Bochum , initially as an assistant doctor, from 2003 as senior physician and from 2004 as senior physician and deputy clinic director. In 2002 he graduated as a specialist in oral and maxillofacial surgery and a specialist dentist in oral surgery and in 2005 obtained the additional title of plastic surgery . In 2006 he completed his habilitation and venia legendi for the subject of oral and maxillofacial surgery with the subject "Monitoring and optimization of the perfusion of microsurgical transplants and development of retrograde perfusion for perforated flaps in the mouth, jaw and face". In 2006 he became a Fellow of the European Board of Oral & Maxillofacial Surgeons (FEBOMFS, Barcelona). Hölzle was positively influenced between 1992 and 2010 by Klaus-Dietrich Wolff , most recently at the Klinikum rechts der Isar of the Technical University of Munich . From 2007 to 2011 he was Senior Consultant and Deputy Clinic Director of the Clinic for Oral and Maxillofacial Surgery at the Klinikum rechts der Isar of the Technical University of Munich. In 2010 he received a call to the full professorship at the Clinic for Oral and Maxillofacial Surgery at the Paracelsus Medical University Salzburg - listed as primo loco . Since 2011 he has been professor for oral and maxillofacial surgery at the Aachen University Hospital of the RWTH Aachen University.

Scientific contribution

Hölzle dealt with the topics among other things

  • Examination of the anatomy of microsurgical transplants and their vascular courses and histology ,
  • Microcirculation and ischemic preconditioning of microsurgical grafts,
  • Monitoring of microsurgical transplants,
  • Computer planning and surgical guides for microsurgical bone reconstruction.
  • Automation in microsurgical bone reconstruction and osteoplastic cranioplasty.
  • Experimental and clinical evaluation of intraoral zirconium implants

Research into microsurgical tissue transplants was - in addition to his doctorates and habilitation - the focus of his scientific work. In addition, scientific publications appeared on an objectifying assessment of the vitality of the transplanted tissue and on the monitoring of differently composed tissue units. Furthermore, Hölzle dealt with the microcirculatory properties of these transplants and the phenomenon of reperfusion damage. After implementing the computer planning and template technology in microsurgical bone transfer, Hölzle dealt with the utilization for meaningful clinical indications. In Hölzle's clinic, the first computer-planned, template-guided, microsurgical and less invasive removal of an iliac crest transplant was developed by medial (A. Modabber et al., 2017). So far, only the lateral approach has been described. In addition, in his clinic he drove the further development of the automation of bony microsurgical reconstructions and their transfer for osteoplastic cranioplasties (S. Raith et al., 2018 and A. Modabber et al., 2019).

Membership in international scientific associations

honors and awards

  • 2007 Martin Waßmund Prize of the German Society for Oral and Maxillofacial Surgery for the work "Monitoring and optimization of the perfusion of microsurgical transplants and development of retrograde perfusion for perforated flaps in the mouth, jaw and face area"
  • 2008 Scientific Award Journal of Cranio-Maxillo-Facial Surgery for “Top 10 Cited Papers 2006–2008”, second place
  • 2009 Scientific Award Journal of Cranio-Maxillo-Facial Surgery , "Top 25 Hottest Articles", third place
  • 2013 Fellow of the International Team of Implantology, ITI Switzerland
  • 2014 Prize of the Medical Faculty of RWTH Aachen for the best dissertation (as doctoral supervisor)
  • Borchers badge from RWTH Aachen University (as doctoral supervisor).

Numerous awards in teaching, including a. > 10 gold medals for the best clinical lecture in dentistry at RWTH Aachen University

Publications

Books

Hölzle is co-editor of three textbooks in the field of dental surgery and oral and maxillofacial surgery:

  • with Klaus-Dietrich Wolff (Ed.): Raising of Microvascular Flaps: A Systematic Approach. 2nd Edition. Springer, 2011.
  • with Jochen Jackowski and Hajo Peters (eds.): Practical Guide to Dental Surgery. Urban & Fischer Verlag / Elsevier, 2007.
  • with Jochen Jackowski, Hajo Peters and Frank Hölzle (eds.): Dental surgery. Springer-Verlag Berlin Heidelberg (2017)

Technical article

Hölzle published more than 200 scientific publications and book chapters; > 400 scientific lectures and posters, acquisition of> 4 million euros in third-party funding. Organization and management of over 100 national and international courses, workshops and conferences in the field of flap lifting, microsurgery, tumor surgery and implantology. Education> 1,000 doctors and dentists on courses in reconstructive surgery and implantology since 1994.

PubMed list of publications (excerpt) Frank Hölzle selection

  • F. Hölzle, M. Klein, O. Schwerdtner, T. Lueth, J. Albrecht, N. Hosten, R. Felix, J. Bier: Intraoperative computed tomography with the mobile CT Tomoscan M during surgical treatment of orbital floor fractures. Int J Oral Maxillofac Surg. (2001) 30: 26-31.
  • F. Hölzle, K.-D. Wolff: Anatomic position of the lingual nerve in the mandibular third molar region with special consideration of an atrophied mandibular crest: An anatomical study. Int J Oral Maxillofac Surg. (2001) 30: 333-338.
  • F. Hölzle, D. Löffelbein, D. Nolte, K.-D. Wolff: Free flap monitoring using simultaneous non-invasive laser Doppler flowmetry and tissue spectrophotometry. J Craniomaxillofac Surg. (2006) 34: 25-33.
  • F. Hölzle, K.-D. Wolff, C. Mohr: Reconstructive oral and maxillofacial surgery. Dtsch Arztebl Int. (2008) 47: 815-22.
  • F. Hölzle, A. Rau, DJ Loeffelbein, MR Kesting, T. Mücke, K.-D. Wolff: Results of monitoring fasciocutaneous, myocutaneous, osteocutaneous and perforator flaps: 4-year experience with 166 cases. Int J Oral Maxillofac Surg. (2010) 37: 21-28.
  • A. Modabber, SC Möhlhenrich, N. Ayoub, M. Hajji, S. Raith, S. Reich, T. Steiner, A. Ghassemi, F. Hölzle: Computer-Aided Mandibular Reconstruction with Vascularized Iliac Crest Bone Flap and Simultaneous Implant Surgery . J Oral Implantol. (2015) 41: e189-94.
  • A. Modabber, N. Ayoub, A. Bock, SC Möhlhenrich, B. Lethaus, A. Ghassemi, DA Mitchell, F. Hölzle: Medial approach for minimally-invasive harvesting of a deep circumflex iliac artery flap for reconstruction of the jaw using virtual surgical planning and CAD / CAM technology. Br J Oral Maxillofac Surg. (2017) 55: 946-951.
  • S. Raith, A. Rauen, SC Möhlhenrich, N. Ayoub, F. Peters, T. Steiner, F. Hölzle, A. Modabber: Introduction of an algorithm for planning of autologous fibular transfer in mandibular reconstruction based on individual bone curvatures. Int J Med Robot. (2018) 14 doi: 10.1002 / rcs.1894
  • A. Modabber, A. Rauen, N. Ayoub, SC Möhlhenrich, F. Peters, K. Kniha, F. Hölzle, S. Raith: Evaluation of a novel algorithm for automating virtual surgical planning in mandibular reconstruction using fibula flaps. J Craniomaxillofac Surg. (2019) 47: 1378-1386.

Web links

Individual evidence

  1. ↑ Prof. Frank Hölzle is the new director of the Clinic for Oral and Maxillofacial Surgery , portrait and short biography on the pages of Management & Krankenhaus
  2. ↑ F. Hölzle, D. Löffelbein, D. Nolte, K.-D. Wolff: Free flap monitoring using simultaneous non-invasive laser Doppler flowmetry and tissue spectrophotometry. In: J Craniomaxillofac Surg. 34, 2006, pp. 25-33.
  3. ↑ F. Hölzle, A. Rau, DJ Loeffelbein, MR Kesting, T. Mücke, K.-D. Wolff: Results of monitoring fasciocutaneous, myocutaneous, osteocutaneous and perforator flaps: 4-year experience with 166 cases. In: Int J Oral Maxillofac Surg. 37, 2010, pp. 21-28.
  4. ↑ TT Sönmez, O. Al-Sawaf, G. Brandacher, I. Kanzler, N. Tuchscheerer, M. Tohidnezhad, A. Kanatas, M. Knobe, A. Fragoulis, R. Tolba, D. Mitchell, T. Pufe, CJ Wruck, F. Hölzle, EA Liehn: A novel laser-Doppler flowmetry assisted murine model of acute hindlimb ischemia-reperfusion for free flap research. In: PLoS One. 8 (6), 2013 Jun 20, p. E66498. doi: 10.1371 / journal.pone.0066498 .
  5. ^ O. Al-Sawaf, A. Fragoulis, C. Rosen, N. Keimes, EA Liehn, F. Hölzle, YW Kan, T. Pufe, TT Sönmez, CJ Wruck: Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury. In: J Pathol. 234 (4), 2014 Dec, pp. 538-547. doi: 10.1002 / path.4418 .
  6. ↑ A. Modabber, M. Gerressen, N. Ayoub, D. Elvers, JP Stromps, D. Riediger, F. Hölzle, A. Ghassemi: Computer-assisted zygoma reconstruction with vascularized iliac crest bone graft. In: Int J Med Robot. 9 (4), 2013 Dec, pp. 497-502. doi: 10.1002 / rcs.1557 .
  7. ↑ A. Modabber, SC Möhlhenrich, N. Ayoub, M. Hajji, S. Raith, S. Reich, T. Steiner, A. Ghassemi, F. Hölzle: Computer-Aided Mandibular Reconstruction with Vascularized Iliac Crest Bone Flap and Simultaneous Implant Surgery. In: J Oral Implantol. (2014)
personal data
SURNAME Hölzle, Frank
BRIEF DESCRIPTION German oral and maxillofacial surgeon
DATE OF BIRTH February 13, 1968
PLACE OF BIRTH Calw