Holm Schneider

Holm Schneider (2010)

Holm Schneider (born January 1, 1969 in Leipzig ) is a German pediatrician , genetic researcher and author . He is professor and director of the Center for Ectodermal Dysplasia at the University Hospital Erlangen . His books on the life paths of people with disabilities and his commitment as the first deputy federal chairman of Aktion Lebensrecht für Alle (ALfA), the largest German organization for the rights of life , made him known outside of his academic work. He is also involved in the Forum of German Catholics and was a member of the board of trustees of ProLife Germany .

Life

Holm Schneider studied medicine at the Universities of Leipzig and London from 1989 to 1995 as a scholarship holder of the German National Academic Foundation and received his doctorate in Leipzig in 1996. After a year at the Leipzig University Hospital , he went to the University of London as a postdoctoral fellow for three years . In 1999 he moved to the Friedrich-Alexander-Universität Erlangen-Nürnberg , where he completed his habilitation and completed his training as a specialist in paediatrics. In 2006 he was appointed professor for experimental neonatology at the Medical University of Innsbruck , where he set up the research department of the same name. In March 2008 he accepted a professorship for paediatrics at the University Hospital Erlangen. He researches congenital diseases that are caused by genetic defects or a disturbed differentiation of body cells, especially genetic skin diseases (see genodermatosis ). Since March 2017 he has headed the expert group on ectodermal dysplasia and related hereditary diseases in the European Reference Network (ERN) Skin .

In April 2018, Schneider published the results of several attempts at healing the anhidrotic form of ectodermal dysplasia that he carried out in 2016 . Until then, there was no therapeutic option for this disease based on a genetic defect . The method used in the treatment of the affected children to smuggle a missing protein into the blood of the unborn child by coupling it to the Fc component of human antibodies as a transport aid is discussed as a possible basis for the treatment of other hereditary diseases.

Schneider is married and has six children.

Volunteering

Holm Schneider was a member of the administrative board of the health insurance company for industry, trade and insurance BKK IHV in Wiesbaden, which ended its controversial cooperation with ProLife Germany in June 2012. In December 2012 he left the Board of Directors.

He played a key role in the “Stop PGD” campaign, which wanted to prevent the introduction of pre-implantation diagnostics in Germany in 2010 . In lectures and press interviews, he expressed sharp criticism of the introduction of a controversial prenatal blood test for Down syndrome . In an interview with Welt am Sonntag , he spoke out against the planned inclusion of this test in the catalog of services of the statutory health insurance companies with the words "This is equivalent to a right to hunt children with Down syndrome". Real inclusion begins "before birth". In current lectures on "Why a perfect baby is an illusion and a disabled one is not a catastrophe", he advocates correcting the "images of disability in our heads".

Schneider is particularly committed to children with trisomy, is a volunteer in the Running Club 21, a sports club for people with Down syndrome, and in the medical advisory boards of the self-help groups Ectodermal Dysplasia e. V. and interest group Epidermolysis bullosa-DEBRA Germany e. V. and writes books about children and adults who look different from most of them. He also writes guest articles on bioethical topics for the Frankfurter Allgemeine Zeitung and Die Tagespost . He is a member of the editorial board of the Zeitschrift für Lebensrecht .

Awards

Schneider's first scientific work was awarded the Rolf Emmrich Prize of the Saxon Society for Internal Medicine (1996), the Dr. Carl Zeise Prize of the University of Leipzig (1996), the Advancement Prize of the Society for Thrombosis and Hemostasis Research (2002) and the Arthur Vick Prize (2004).

In 2006, together with Regina Betz from the University of Bonn, Holm Schneider was awarded the Gottron Just Science Prize for his approach to treating the hereditary disease epidermolysis bullosa .

In 2008 Schneider and his working group received the gold medal of the Union of European Neonatal and Perinatal Societies (UENPS) for the proof that bone, cartilage, skeletal muscle and heart muscle cells can be grown from certain stem cells of the umbilical cord blood.

In 2015 he received the Erlangen Inclusion Prize for his exceptional commitment to people with disabilities .

For his work on the prenatal therapy of ectodermal dysplasia, he received the 2018 Care-for-Rare Science Award 2019 in addition to the science award of the European Society for Pediatric Dermatology .

Publications (selection)

scientific publications

• H. Schneider, C. Coutelle: In utero gene therapy: the case for. In: Nature Medicine . Volume 5, Number 3, March 1999, pp. 256-257, ISSN  1078-8956 . doi: 10.1038 / 6458 . PMID 10086371 .
• SN Waddington, SM Buckley, M. Nivsarkar, S. Jezzard, H. Schneider, T. Dahse, G. Kemball-Cook, M. Miah, N. Tucker, MJ Dallman, M. Themis, C. Coutelle: In utero gene Transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor. In: Blood . Volume 101, Number 4, February 2003, pp. 1359-1366, ISSN  0006-4971 . doi: 10.1182 / blood-2002-03-0779 . PMID 12393743 .
• A. Akhmetshina, K. Palumbo, C. Dees, C. Bergmann, P. Venalis, P. Zerr, A. Horn, T. Kireva, C. Beyer, J. Zwerina, H. Schneider, A. Sadowski, MO Riener , OA MacDougald, O. Distler, G. Schett, JH Distler: Activation of canonical Wnt signaling is required for TGF-β-mediated fibrosis. In: Nature Communications . 3, Article number: 735 doi: 10.1038 / ncomms1734
• F. Pacho, G. Zambruno, V. Calabresi, D. Kiritsi, H. Schneider: Efficiency of translation termination in humans is highly dependent upon nucleotides in the neighborhood of a (premature) termination codon. In: Journal of Medical Genetics . Volume 48, Number 9, September 2011, pp. 640-644, ISSN  1468-6244 . doi: 10.1136 / jmg.2011.089615 . PMID 21693480 .
• K. Hermes, P. Schneider, P. Krieg, A. Dang, K. Huttner, H. Schneider: Prenatal therapy in developmental disorders: drug targeting via intra-amniotic injection to treat X-linked hypohidrotic ectodermal dysplasia . In: Journal of Investigative Dermatology . Volume 134, Number 12, December 2014, pp. 2985-2987, ISSN  0022-202X . doi: 10.1038 / jid.2014.264 . PMID 24950237 .
• H. Schneider et al .: Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia. In: The New England Journal of Medicine, April 26, 2018, 26; 378 (17): 1604-1610. doi: 10.1056 / NEJMoa1714322 PMID 29694819

Books

• Why vampires don't like to run. Stachelbart, Erlangen 2011; 3rd edition 2015, ISBN 978-3-9814210-1-9 (translated into several languages).
• How the bankrupt vulture disappeared. Stachelbart, Erlangen 2012, ISBN 978-3-9814210-7-1 .
• “What should become of this child?” 7 résumés of people with Down syndrome. Neufeld Verlag , Schwarzenfeld 2014; 2nd edition, ISBN 978-3-86256-047-9 .
• New nests for the swallows. Stachelbart, Erlangen 2014, ISBN 978-3-9814210-8-8 .
• A baby in the belly. Neufeld Verlag, Cuxhaven 2019, 3rd edition, ISBN 978-3-86256-058-5 .
• Daring relationships. Neufeld Verlag, Schwarzenfeld 2016, ISBN 978-3-86256-070-7 .

Individual evidence

1. ↑ Kürschner's German Scholar Calendar . 2012, p. 3562.
2. ↑ Federal Board . Action Right to Live for All; Retrieved July 2, 2016.
3. ↑ Holm Schneider ( Memento from May 5, 2012 in the Internet Archive ), website of the Forum of German Catholics.
4. ^ Kuratorium ( Memento of July 2, 2016 in the Internet Archive ), ProLife Germany website, accessed on July 2, 2016.
5. ^ Annual report 2009 of the German Academic Scholarship Foundation , p. 179.
6. ↑ Presented: Prof. Holm Schneider , Innsbruck Medical University , January 16, 2007, accessed on July 2, 2016.
7. ↑ Prof. Dr. H. Schneider heads European expert group , Erlangen University Hospital , September 29, 2017, accessed on January 3, 2018.
8. ↑ Press release from the Friedrich-Alexander-Universität Erlangen-Nürnberg : The world's first successful therapy attempts for the hereditary disease ectodermal dysplasia. Three children out of danger thanks to prenatal protein injection. dated April 26, 2018, accessed on April 26, 2018 and press release from the University Hospital Erlangen : The world's first successful therapeutic attempts for the hereditary disease ectodermal dysplasia. dated April 26, 2018, accessed April 26, 2018
9. ↑ Holm Schneider et al .: Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia . In: The New England Journal of Medicine , April 26, 2018, 26,378 (17), pp. 1604-1610, PMID 29694819 , doi: 10.1056 / NEJMoa1714322
10. ↑ Christina Berndt: Doctors treat genetic defects in the womb for the first time . In: Süddeutsche Zeitung , April 25, 2018.
11. ^ Richard Friebe: German doctors treat hereditary disease in the womb . In: Der Tagesspiegel , April 27, 2018.
12. ↑ Twins treated for genetic disorder in the womb . CNN , May 18, 2018.
13. ↑ Holm Schneider . Neufeld Verlag ; accessed on January 4, 2015.
14. ↑ Katrin Elger: Health: Holy Alliance . In: Der Spiegel . No. 7 , 2012 ( online ).
15. ↑ press release. ( Memento from June 30, 2012 in the Internet Archive ) BKK IHV , June 21, 2012.
16. ↑ Board of Directors and Administrative Board ( Memento of the original from December 3, 2013 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. BKK IHV , accessed on January 29, 2013 
17. ↑ Holm Schneider . Stop PID website, accessed December 1, 2013.
18. ↑ Interventions before birth . In: Trierischer Volksfreund , July 20, 2012.
19. ↑ Sabine Menkens: “That is a right to hunt disabled children” . In: Welt am Sonntag , February 26, 2017.
20. ↑ Heike Duczek: “A perfect baby is an illusion”: Before appearing in Rosenheim, the doctor demands inclusion instead of selection . In: Oberbayerisches Volksblatt , October 22, 2019.
21. ↑ I can walk like you . In: Pharmazeutische Zeitung , edition 03/2013.
22. ↑ Medical Advisory Board ( Memento from December 3, 2013 in the Internet Archive ), Self-Help Group Ectodermal Dysplasia e. V.
23. ^ Medical Advisory Board , Interest Group Epidermolysis bullosa e. V.
24. ↑ Holm Schneider: Nico, Chiara and Daniela . In: FAZ , October 19, 2010.
25. ↑ Holm Schneider: Today I'm going to buy children . In: Die Tagespost , April 9, 2016.
26. ↑ Erlangen physicians grow cells from umbilical cord blood .
27. ↑ Erlangen: Lebenshilfe distinguishes living inclusion . In: Nürnberger Nachrichten , November 24, 2015.
28. ↑ Pro.Movere 2019: Awards to Prof. Dr. Holm Schneider and Georg Randlkofer Care-for-Rare Foundation ; accessed on November 28, 2019.