Leuprorelin

Structural formula
General
Non-proprietary name	Leuprorelin
other names	5-Oxo-Pro-His-Trp-Ser-Tyr-d-Leu-Leu-Arg-Pro-NH-C2H5
Molecular formula	C 59 H 84 N 16 O 12
External identifiers / databases
EC number	633-395-9
ECHA InfoCard	100.161.466
PubChem	657181
ChemSpider	571356
DrugBank	DB00007
Wikidata	Q907160
Drug information
ATC code	L02 AE02
Drug class	Antiandrogens
properties
Molar mass	1209.40 g · mol -1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Acetate salt;	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
Toxicological data	137 mg kg −1 ( LD 50 , mouse , iv , acetate)
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Leuprorelin is a GnRH analog that stops hormone production and is used to artificially lower testosterone or estrogen levels in the blood. It is a peptide made up of nine amino acids .

indication

Leuprorelin is used among other things at

the treatment of fibroids of the uterus ,
the therapy of breast cancer ,
Endometriosis ,
the therapy of metastatic prostate cancer ,
early onset of puberty ( pubertas praecox ) in girls and boys,
Sex drive offenders due to the inhibition of sex hormone production.
Cluster headache

Others

Leuprorelin is subject to a prescription in Germany. When protected from light and stored below 25 ° C, two-chamber syringes have a shelf life of 36 months. The application interval for monthly deposits may not exceed 32 days. Takeda achieved net sales of around EUR 8 billion with leuprorelin products in the 2012 financial year.

Trade names

Monopreparations

Enantone (D, A), Trenantone (D, A), Sixantone (D, A), Lucrin (CH), various generics (D, CH)

Individual evidence

↑ Data sheet Leuprolide acetate salt from Sigma-Aldrich , accessed on May 29, 2011 ( PDF ).
↑ Entry on leuprorelin in the ChemIDplus database of the United States National Library of Medicine (NLM) .
↑ GenScript catalog ( Memento of 17 October 2006 at the Internet Archive ), accessed on June 13 of 2007.
↑ Hartmut Göbel: Cluster headache and other trigemino-autonomic headache disorders . In: The headache . Springer Berlin Heidelberg, Berlin, Heidelberg 2012, ISBN 978-3-642-20694-8 , pp. 497-538 , doi : 10.1007 / 978-3-642-20695-5_9 ( springer.com [accessed October 22, 2019]).
^ Takeda Pharmaceutical Company Limited .

[Sigma-1] Data sheet Leuprolide acetate salt from Sigma-Aldrich , accessed on May 29, 2011 ( PDF ).

[ChemIDplus-2] Entry on leuprorelin in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[3] GenScript catalog ( Memento of 17 October 2006 at the Internet Archive ), accessed on June 13 of 2007.

[4] Hartmut Göbel: Cluster headache and other trigemino-autonomic headache disorders . In: The headache . Springer Berlin Heidelberg, Berlin, Heidelberg 2012, ISBN 978-3-642-20694-8 , pp. 497-538 , doi : 10.1007 / 978-3-642-20695-5_9 ( springer.com [accessed October 22, 2019]).

[5] Takeda Pharmaceutical Company Limited .