Michael Höckel

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Michael Höckel (* 1950 in Flörsheim ) is a German chemist , gynecologist and obstetrician .

Live and act

Michael Höckel first studied chemistry at Johannes Gutenberg University Mainz , where he obtained his diploma in 1973 and in 1978 he was awarded a Dr. rer. nat. received his doctorate .
Also in Mainz , he completed a second degree of Medicine and received in 1980 the approval of a doctor .
At the University Women's Clinic in Mainz, he received training from 1980 to 1986 under Volker Friedberg as a specialist in gynecology and obstetrics, and in 1982 he was awarded a Dr. med. PhD.
In 1985 Höckel completed a research stay at the Boston Children's Hospital and in 1986 at the Massachusetts General Hospital of Harvard Medical School .
Back in Mainz in 1987 he was appointed senior physician at the university women's clinic and qualified as a professor in 1988 in the field of gynecology and obstetrics.
In 1990 he was visiting physician at the Department of Reconstructive Surgery at Emory Clinic , Atlanta , and in 1991 at the Department of Radiation Oncology at Massachusetts General Hospital, Boston . In 1993 Michael Höckel became Visiting Professor at the Cross Cancer Institute , Edmonton and at the Tom Baker Cancer Center , Calgary ( Canada ).
The University of Mainz appointed him extraordinary professor for gynecology and obstetrics in 1994 .
In the same year he became Visiting Professor at Princess Margaret Hospital and Bayview Cancer Center , Toronto (Canada), in 1995 at the Department of Gynecology at Yale University , New Haven , and at the Departments of Gynecology, Pathology and Radiation Oncology at Duke University , Durham , and in 1996 at Harvard Medical School , Boston, Bowman Gray Medical School, Wake Forest University , Winston-Salem , at the National Cancer Institute , Bethesda , and at the European Institute of Oncology , Milan ( Italy ).
In 1998 Michael Höckel was appointed to the chair of gynecology at the University of Leipzig and head of the Trier Institute .
Höckel scientifically investigated the oxygen supply of malignant tumors and their effects.
On the basis of developmental and embryonic studies, he developed a new oncological principle of radicality in the treatment of cervical and vulvar cancer . From this he developed the method of total mesometrial resection of the uterus (TMMR) for the treatment of cervical carcinoma, in which the tumor is removed within the limits of the morphogenetic unit of its origin. Anatomical structures that do not belong to this unit derived from the embryonic development can be preserved despite the spatial proximity to the tumor .
He developed the laterally extended endopelvic resection (LEER) method to treat relapses of cervical carcinoma.
In 2005, Höckel founded the Leipzig School of Radical Pelvic Surgery to convey the principle of locoregional tumor spread derived from embryonic development and its implementation in radical surgical methods for tumors of the female genitalia.
Michael Höckel headed the clinic for 15 years until his retirement in 2017. His successor was Bahriye Aktas on July 1, 2017 .

Fonts (selection)

  • F1-ATPase from Micrococcus sp. (ATCC 398): Pure preparation and investigations into the structure and the enzymatic reaction mechanism. Dissertation Johannes Gutenberg University Mainz 1978
  • Determination of long-chain free fatty acids in the serum of young women in different phases of the menstrual cycle using a newly developed gas chromatographic micro-method. Dissertation Johannes Gutenberg University Mainz 1982
  • Therapeutic angiogenesis: Investigations into the biological mode of action of the monocytic angiogenesis factor angiotropin and the possibilities of its use in operative medicine. Habilitation thesis Johannes Gutenberg University Mainz 1989
  • Michael Höckel, Nadja Dornhöfer: The Hydra phenomenon of cancer: Why tumors recur locally after microscopically complete resection. Cancer Res, 65 (2005), pp. 2997-3002, PMID 15833823
  • Michael Höckel: Total Mesometrial Resection: A New Radicality Principle in the Surgical Therapy of Cervical Carcinoma. Onkologe 12 (2006), pp. 901-907, doi: 10.1007 / s00761-006-1110-y
  • Michael Höckel: Total Mesometrial Resection (TMMR): Surgical treatment of cervical cancer on the basis of a surgical anatomy derived from embryonic and fetal development. GebFra 62 (2003), pp. 1146-1152, doi: 10.1055 / s-2003-43458
  • Michael Höckel, L.-C. Horn, B. Hentschel, S. Höckel, G. Naumann: Total mesometrial resection: High resolution nerve-sparing radical hysterectomy based on developmentally defined surgical anatomy. Int J Gynecol Cancer 13 (2003), pp. 791-803, PMID 14675316
  • Michael Höckel: Total Mesometrial Resection (TMMR). Gynäkologe 41 (5) 2008, pp. 361-368, doi: 10.1007 / s00129-008-2133-9
  • Michael Höckel, L.-C. Horn, H. Fritsch: Association between the mesenchymal compartment of uterovaginal organogenesis and local tumor spread in stage IB-IIB cervical carcinoma: a prospective study. Lancet Oncol 6 (2005), pp. 751-56, PMID 16198980
  • Michael Höckel, LC Horn, N. Manthey, UD Braumann, U. Wolf, G. Teichmann, K. Frauenschläger, N. Dornhöfer, J. Einenkel: Resection of the embryologically defined uterovaginal (Müllerian) compartment and pelvic control in patients with cervical cancer: a prospective analysis. Lancet Oncology 10 (2009), pp. 683-692, doi: 10.1016 / S1470-2045 (09) 70100-7

Web links

Individual evidence

  1. ↑ Increasing aggressiveness of tumors. , Press release of the University of Leipzig from July 23, 2001
  2. Jump up ↑ Karlheinz Schlenger, Michael Höckel, Margarete Mitze, Uwe Schäffer, Wolfgang Weikel, Paul Georg Knapstein, Annette Lambert: Tumor vascularity - a novel prognostic factor in advanced cervical carcinoma. Gynecol Oncol 59 (1995), pp. 57-66, PMID 7557616 , doi: 10.1006 / gyno.1995.1268
  3. ↑ Michael Höckel: Total Mesometrial Resection (TMMR): Surgical therapy of cervical cancer on the basis of a surgical anatomy derived from embryonic and fetal development. GebFra 62, pp. 1146-1152, 2003 doi : 10.1055 / s-2003-43458
  4. ↑ New surgery to treat relapses of cervical cancer. Press release of the University of Leipzig from February 1, 2001
  5. ^ Michael Höckel: Laterally extended endopelvic resection (LEER) - Principles and practice. Gynecol Oncol 111 (2008), pp. S13-S17, PMID 18723213 , doi: 10.1016 / j.ygyno.2008.07.022
  6. ^ Philosophy of the Leipzig School of Radical Pelvic Surgery
  7. ↑ Prof. Bahriye Aktas takes over the management of the UKL Clinic for Gynecology , press release of the Leipzig University Medical Center from June 26, 2017
personal data
SURNAME Höckel, Michael
BRIEF DESCRIPTION German gynecologist and obstetrician, chemist
DATE OF BIRTH 1950
PLACE OF BIRTH Flörsheim