Patricia A. Jacobs

Patricia Ann Jacobs (* 8. October 1934 ) is a British geneticist at Salisbury District Hospital of the University of Southampton .

Life

Jacobs received a Masters degree from Mount Holyoke College in South Hadley , Massachusetts . From 1957/1958 Jacobs worked for Michael Court Brown in the working group for clinical radiation effects at the British Medical Research Council in Edinburgh , Scotland . In 1970 she went to the United States and from 1972 had a professorship in anatomy and reproductive biology at the University of Hawaii School of Medicine . From 1985 to 1987 she headed the Department of Human Genetics in Pediatrics at Cornell University in the City of Ithaca , New York . In 1988 she returned to the UK to head the Wessex Genetics Laboratory Service in Salisbury and has since been a professor of human genetics at the University of Southampton .

Act

In 1959 Jacobs was the first to describe a chromosomal aberration of the sex chromosomes : Klinefelter's syndrome with the karyotype 47, XXY, that is, an additional X chromosome . Since this discovery, the Y chromosome has been considered to determine the male sex in humans. In the period that followed, Jacobs dealt with a wide variety of issues relating to human cytogenetics : the frequency, causes and epidemiology of numerical chromosome aberrations (too large or too small a number of chromosomes); with the phenotype in structural chromosomal aberrations (especially the deletion ); with cytogenetic causes of miscarriages and with the fragile X syndrome as the “prototype” of trinucleotide diseases .

Awards (selection)

• 1977 Fellow of the Royal Society of Edinburgh
• 1981 William Allan Award from the American Society of Human Genetics
• 1993 Fellow of the Royal Society
• 1998 member of the Academy of Medical Sciences
• 1999 Officer of the Order of the British Empire
• 2002 Honorary Doctorate from the University of St Andrews
• 2009 Foreign member of the National Academy of Sciences
• 2011 March of Dimes Prize in Developmental Biology

Web links

• Patricia Jacobs at the University of Southampton (southampton.ac.uk)
• Jacobs, Patricia Ann: Archives and Manuscripts at wellcomelibrary.org
• Prof. Patricia Jacobs, OBE, FRS's Biography at debretts.com

Individual evidence

1. ^ PA Jacobs, JA Strong: A case of human intersexuality having a possible XXY sex-determining mechanism. In: Nature . Volume 183, Number 4657, January 1959, pp. 302-303, ISSN  0028-0836 . PMID 13632697 .
2. ↑ RSE Fellows (PDF, 218 kB) at the Royal Society of Edinburgh (royalsoced.org.uk); Retrieved March 25, 2013
3. ^ PA Jacobs: The William Allan Memorial Award address: human population cytogenetics: the first twenty-five years. In: American Journal of Human Genetics . Volume 34, Number 5, September 1982, pp. 689-698, ISSN  0002-9297 . PMID 6751075 . PMC 1685430 (free full text).
4. ^ Fellows of the Royal Society (royalsociety.org); Retrieved March 25, 2013
5. ↑ Professor Patricia Jacobs OBE FRS FRSE FMedSci at the Academy of Medical Sciences (acmedsci.ac.uk); accessed on May 6, 2019.
6. ↑ Patricia A. Jacobs at the National Academy of Sciences (nasonline.org); Retrieved March 25, 2013
7. ↑ March of Dimes Awards $ 250,000 Prize to Scientists Who Explained Human Sex Chromosomes - March of Dimes. In: marchofdimes.org. Retrieved February 20, 2016 .