Patrick S. Moore
Patrick S. Moore (born October 21, 1956 in Seattle ) is an American epidemiologist and virologist , known for the discovery of two human tumor viruses .
Life
Patrick Moore studied chemistry and biology at Westminster College in Salt Lake City from 1974 to 1977 to a bachelor's degree and from 1977 to 1980 chemistry at Stanford University to a master's degree. After moving to the University of Utah , he studied anatomy at the College of Medicine from 1980 to 1985 ( MD degree and also a Master of Philosophy degree, MPhil). After another move in 1989 to the University of California, Berkeley , Moore earned another degree in 1990 as a Master of Public Health (MPH).
In 1985 Moore worked at the Bawku Presbyterian Hospital in Ghana and in 1986 in an onchocerciasis research project in Liberia . From 1987 to 1989 he worked as an epidemiologist at the Centers for Disease Control and Prevention (CDC), where he rules against meningitis ( meningococcal - encephalitis ) developed; for this work he received the CDC's Langmuir Prize. He then went from 1989 to 1991 as a trainee at the Center for AIDS Prevention Studies (CAPS) in San Francisco , where he was involved in studies on AIDS prevention in California. From 1991 to 1993 he was head of the arbovirus group at the CDC in Fort Collins . As part of this employment relationship, he was u. a. temporarily posted to Chad (1988), Ethiopia (1989) and the Northern Mariana Islands (1991) in connection with meningococcal encephalitis epidemics . In November and December 1992 - during the Somali civil war - he led a team to avert the associated famine.
From 1993 to 1994 he worked as an epidemiologist for the City of New York City (Deputy Commissioner, NY City Department of Health), but in 1994 he turned to molecular genetic virus research as an assistant professor in the laboratory of his wife Yuan Chang at Columbia University . He was appointed Associate Professor in 1995 and finally Professor of Public Health in 1998 . In 2002, he and his wife, who also received a professorship in Pittsburgh , moved to the University of Pittsburgh , where he was appointed professor of microbiology and molecular genetics . Since 2012 his chair has been named Distinguished and American Cancer Society Professor .
research
At Columbia University, Moore and his wife Yuan Chang discovered one of the seven known cancer viruses in humans in 1994: human herpesvirus 8 (HHV-8), initially named Kaposi's sarcoma-associated herpesvirus , KSHV. They showed that the virus causes Kaposi's sarcoma and lymphoma of serous body cavities (Primary Effusion Lymphoma). In 2008 they found a second human cancer virus, Merkel cells - polyomavirus , the likely cause of Merkel cell carcinoma . They each sequenced the genome and identified oncogenes associated with it .
In connection with the discovery of the polyomavirus, they developed a new technique (Digital Transcriptome Subtraction, DTS) to detect the virus. The technique used in the search for the cause of Kaposi's sarcoma was based on the idea of subtracting the entire human genome from the total genome of the tumor cells, so that in the best case only that DNA remains as the "remainder" that does not belong to the genome of the Humans, but belongs to the genome of the virus. The polyomavirus was identified using a modified strategy in which only the mRNA was examined.
Honors
Together with Yuan Chang, Patrick Moore received the Meyenburg Prize in 1997 , the Robert Koch Prize in 1998 , the Charles S. Mott Prize for Cancer Research from General Motors in 2003 , the Carnegie Life Sciences Award in 2009 and both the Paul-Ehrlich- and Ludwig Darmstaedter Prize as well as the Passano Award .
Moore is an elected member of the American Academy of Microbiology, the National Academy of Sciences, and the Academy of American Physicians.
Since 2017, Clarivate Analytics has counted him among the favorites for a Nobel Prize in Physiology or Medicine ( Clarivate Citation Laureates , formerly Thomson Reuters Citation Laureates ) due to the number of his citations .
Web links
Individual evidence
- ↑ Background information on the awarding of the Paul Ehrlich and Ludwig Darmstaedter Prize 2017. On: uni-frankfurt.de of March 14, 2017
- ↑ The 2017 Clarivate Citation Laureates - Clarivate. In: clarivate.com. Retrieved September 21, 2017 .
| personal data | |
|---|---|
| SURNAME | Moore, Patrick S. |
| BRIEF DESCRIPTION | American virologist |
| DATE OF BIRTH | October 21, 1956 |
| PLACE OF BIRTH | Seattle |