Stuart H. Orkin

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Stuart Holland Orkin (born 1946 ) is an American geneticist , hematologist and pediatric oncologist at Harvard Medical School , the Dana-Farber Cancer Institute and the Boston Children's Hospital .

Life

Orkin grew up in Manhattan . He began studying at the Massachusetts Institute of Technology , where he earned a bachelor's degree in life sciences in 1967 . He then moved to Harvard Medical School , where he completed his medical degree with an MD in 1972 . As a postdoctoral fellow with Philip Leder at the National Institutes of Health (NIH), he completed his clinical training in paediatrics and hematology / oncology at Boston Children's Hospital and the Dana-Farber Cancer Institute (DFCI) until 1978 .

Orkin has been a member of the DFCI faculty since 1978. In the same year he also received a first professorship (assistant professor) at Harvard Medical School , in 1986 a full professorship. Today (as of 2016) he is the David G. Nathan Professor of Pediatrics and Head of the Department of Pediatric Oncology.

Orkin has also been doing research for the Howard Hughes Medical Institute since 1986 . Orkin is married and has one daughter.

Act

Orkin deals with gene regulation and differentiation of the hematopoietic stem cells , hereditary diseases of the blood cells and oncogenesis , especially of the cells of hematopoiesis .

Orkin and co-workers were able to identify important regulatory genes for hematopoiesis. His work on the pathology of hereditary disorders of blood formation contributed significantly to the improved diagnosis and therapy of these diseases. Orkin's research group defined various mutations that lead to the various forms of thalassemia , cloned the gene that leads to neptic granulomatosis , and characterized the switch that makes the switch from fetal to adult hemoglobin and demonstrated its regulation.

Orkin's recent work deals with the prenatal diagnosis of genetic disorders or the molecular genetics and biochemistry of phagocytes .

Orkin published (as of 2014) more than 500 scientific publications , of which 225 were cited more than 100 times . Its h-index is 185 (as of May 2019).

Awards (selection)

Web links

Individual evidence

  1. ^ A b Haig H. Kazazian: 2014 William Allan Award Introduction: Stuart Orkin. In: The American Journal of Human Genetics. 96, 2015, p. 352, doi: 10.1016 / j.ajhg.2014.11.018 .
  2. ↑ 1040 Highly Cited Researchers (h> 100) according to their Google Scholar Citations public profiles - Ranking Web of Universities. In: webometrics.info. Retrieved April 16, 2016 .
  3. ^ Stuart Orkin - Google Scholar Citations. In: scholar.google.de. Retrieved May 16, 2019 .
  4. ^ William Dameshek Prize Recipients. In: hematology.org. Retrieved April 16, 2016 .
  5. ↑ Elaine Fuchs, Mark M. Davis, Lily Yeh Jan, Tony Hunter, Yuh Nung Jan, Paul B. Sigler, Peter G. Schultz: The Harvey Lectures . John Wiley & Sons, 2000, ISBN 978-0-471-40125-4 ( limited preview in Google Book Search).
  6. ↑ Stuart Orkin. In: nasonline.org. Retrieved April 10, 2016 .
  7. ^ Stuart Orkin: Health and Medicine Division. (No longer available online.) In: nationalacademies.org. Archived from the original on April 16, 2016 ; accessed on April 16, 2016 .
  8. ↑ Stuart H. Orkin - warrenalpert.org. In: warrenalpert.org. Retrieved April 10, 2016 .
  9. ↑ Book of Members 1780 – present, Chapter O. (PDF; 289 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved May 16, 2019 .
  10. ↑ Jessie Stevenson Kovalenko Medal. In: nasonline.org. Retrieved April 10, 2016 .
  11. ^ Past ASHG Award Recipients - ASHG. In: ashg.org. Retrieved April 10, 2016 .
  12. ^ ASHG Honors Stuart H. Orkin with William Allan Award - ASHG. In: ashg.org. June 26, 2014, accessed April 16, 2016 .
  13. ↑ International König Faisal Prize 2020
personal data
SURNAME Orkin, Stuart H.
ALTERNATIVE NAMES Orkin, Stuart; Orkin, Stuart Holland
BRIEF DESCRIPTION American geneticist, hematologist, and oncologist
DATE OF BIRTH 1946