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{{redirect|Babbage}}
{{Infobox_Company | <!-- infobox source: http://www.hoovers.com/glaxosmithkline/--ID__41781--/free-co-factsheet.xhtml -->
{{Infobox Scientist
company_name = GlaxoSmithKline |
| name = Charles Babbage
company_logo = [[Image:GlaxoSmithKline logo.png|220px|center|]] |
| image = CharlesBabbage.jpg
company_type = [[Public company|Public]] ({{lse|GSK}}<br />{{nyse|GSK}}) |
| image_width =
company_slogan = "Do more, feel better, live longer" |
| caption = Sketch by Henri Claudet, 1860s <ref>[http://www.npg.org.uk/live/search/portrait.asp?LinkID=mp00196&rNo=3 NPG Ax18347]</ref>
foundation = 2000, by merger of '''Glaxo Wellcome''' and '''SmithKline Beecham''' |
| birth_date = {{birth date|1791|12|26|df=y}}
location = {{flagicon|UK}} [[London]], [[England]], [[United Kingdom|UK]] |
| birth_place = [[London]], [[England]]
key_people = [[Sir Chris Gent]], [[Chairman]]<br />[[Andrew Witty]], [[Chief Executive]]<br />[[Julian Heslop]], [[Chief Financial Officer]]<br />[[Dr. Moncef Slaoui]], Chairman of [[Research and Development]]|
| death_date = {{death date and age|1871|10|18|1791|12|26|df=y}}
industry = [[Pharmaceutical industry|Pharmaceutical]]|
| death_place = [[Marylebone]], [[London]], [[England]]
revenue = {{profit}} £22.7 billion (2007) |
| nationality = [[United Kingdom]]
net_income = {{profit}} £7.8 billion (2007) |
| field = [[Mathematics]], [[analytic philosophy]], [[computer science]]
products = [[Central nervous system]], [[Respiration (physiology)|respiratory]], [[antiviral]], [[antibiotic]], [[oncology]] and [[emesis]], [[metabolic]], [[cardiovascular]], [[urogenital]], and [[over-the-counter drug|over-the-counter]] [[medicine]]s; [[vaccines]]; [[Wiktionary:oral|oral]] and [[nutrition]]al healthcare products |
| work_institutions = [[Trinity College, Cambridge]]
num_employees = 103,000 (2008)<ref name=zenobank>{{cite web |url=http://zenobank.com/index.php?symbol=GSK&page=quotesearch |title=Company Profile for GlaxoSmithKline PLC (GSK) |accessdate=2008-10-03}}</ref> |
homepage = [http://www.gsk.com www.gsk.com] |
| alma_mater = [[Peterhouse, Cambridge]]
| doctoral_advisor =
products = [[Imitrex]], [[Valtrex]], [[Boniva]], [[Requip]], [[Flonase]], [[Advair]],[[Veramyst]], [[Vesicare]], [[Zantac]], [[Alli]], [[Panadol night]], [[Tykerb]], [[Relenza]], [[Avandia]], [[Paxil]], [[Aquafresh]], [[Lucozade]], [[Horlicks]], [[Coreg]], [[Augmentin]], [[Levitra]], [[Avodart]], [[Sensodyne]], [[Panadol]], [[Zovirax]], [[Nicoderm]], [[Macleans]], [[Ribena]], [[Amerge]], [[Serodus]], [[Promacta]]
| doctoral_students =
| known_for =
| influences =
| influenced =
| prizes =
| footnotes =
| religion = Christian
}}
}}


'''Charles Babbage, [[Royal Society|FRS]]''' (December 26, 1791 [[London]], [[England]] &ndash; October 18, 1871 [[Marylebone]], [[London]], [[England]])<ref>GRO Register of Deaths: DEC 1871 1a 383 MARYLEBONE - Charles Babbage, aged 79</ref> was an [[England|English]] [[mathematician]], [[philosopher]], [[inventor]] and [[mechanical engineer]] who originated the concept of a programmable [[computer]]. Parts of his uncompleted mechanisms are on display in the [[London Science Museum]]. In 1991 a perfectly functioning [[difference engine]] was constructed from Babbage's original plans. Built to tolerances achievable in the 19th century, the success of the finished engine indicated that Babbage's machine would have worked. Nine years later, the Science Museum completed the [[Computer printer|printer]] Babbage had designed for the difference engine, an astonishingly complex device for the 19th century. Babbage is credited with inventing the first mechanical computer that eventually led to more complex designs.
''' GlaxoSmithKline plc ''' ({{lse|GSK}} {{nyse|GSK}}) is a [[United Kingdom]]-based [[pharmaceutical industry|pharmaceutical]], biological, and [[healthcare]] [[company]]. '''GSK''' is the world's second largest pharmaceutical company and a research-based company with a wide portfolio of pharmaceutical products covering anti-infectives, central nervous system (CNS), respiratory, gastro-intestinal/metabolic, oncology, and vaccines products. It also has a Consumer Healthcare operation comprising leading oral healthcare products, nutritional drinks, and over the counter (OTC) medicines.


==History==
==Biography==
===Birth===
GSK was formed by the merger of GlaxoWellcome (formed from the mergers of Burroughs Wellcome & Company and Glaxo Laboratories), and SmithKline Beecham (from Beecham, and SmithKline Beckman).
The birthplace of Charles Babbage is disputed, but he was most likely born in 44 Crosby Row, [[Walworth Road]], [[London]], [[England]]. A [[blue plaque]] on the junction of Larcom Street and Walworth Road commemorates the event.


Babbage's date of birth was given in his obituary in ''The Times'' as December 26, 1792. However, after the obituary appeared, a nephew wrote to say that Charles Babbage actually was born one year earlier, in 1791. The [[parish register]] of [[St. Mary]]'s [[Newington]], London, shows that Babbage was [[baptized]] on January 6, 1792, supporting a birth year of 1791.<ref>{{cite book | last = Hyman | first = Charles | title = Charles Babbage, Pioneer of the Computer | publisher = Princeton University Press | year = 1982 | page = 5 }}</ref><ref>{{cite book | last = Moseley | first = Maboth | title = Irascible Genius, The Life of Charles Babbage | publisher = Henry Regnery Company (Chicago) | year = 1964 | page = 29 }}</ref><ref>{{cite news | title = [[s:The Times/The Late Mr. Charles Babbage, F.R.S.|The Late Mr. Charles Babbage, F.R.S.]] | work = [[The Times]] | date = }}</ref>
===GlaxoWellcome===
In 1880, '''Burroughs Wellcome & Company''' was founded in London by American pharmacists [[Henry Wellcome]] and [[Silas Mainville Burroughs (pharmacist)|Silas Burroughs]].<ref name="history">[http://www.gsk.com/about/history-noflash.htm GSK History]</ref> The Wellcome Tropical Research Laboratories opened in 1902.<ref name="history"/> In 1959 the Wellcome Company bought McDougall & Robertson Inc. to become more active in animal health.<ref name="history"/> The Wellcome Company production centre was moved from New York to [[North Carolina]] in 1970 and the following year another research centre was built.


Charles' father, Benjamin Babbage, was a banking partner of the Praeds who owned the Bitton Estate in [[Teignmouth]]. His mother was Betsy Plumleigh Teape. In 1808, the Babbage family moved into the old Rowdens house in [[Teignmouth|East Teignmouth]], and Benjamin Babbage became a warden of the nearby St. Michael’s Church.
'''Glaxo''' was founded in [[Bunnythorpe]], [[New Zealand]] in 1904.<ref name="history"/> Originally Glaxo was a baby food manufacturer processing local milk into a baby food by the same name: the product was sold in the 1930s under the slogan "Glaxo builds bonny babies". Still visible on the main street of Bunnythorpe is a derelict dairy factory (factory for drying and processing cows' milk into powder) with the original Glaxo logo clearly visible, but nothing to indicate that this was the start of a major multinational company.


===Education===
Glaxo became Glaxo Laboratories, and opened new units in London in 1935.<ref name="history"/> Glaxo Laboratories bought two companies called '''Joseph Nathan''' and [[Allen & Hanburys]] in 1947 and 1958 respectively.<ref name="history"/> After the Company bought Meyer Laboratories in 1978,<ref name="history"/> it started to play an important role in the US market. In 1983 the American arm Glaxo Inc. moved to [[Research Triangle Park]] (US headquarters/research) and Zebulon (US manufacturing) in North Carolina. Burroughs Wellcome and Glaxo merged in 1995 to form '''GlaxoWellcome'''.<ref name="history"/> In the same year, GlaxoWellcome opened their Medicine Research Centre in Stevenage, England. Three years later GlaxoWellcome bought Polfa Poznan Company in Poland.
{{wikisource|The Times/The Late Mr. Charles Babbage, F.R.S.}}
His father's money allowed Charles to receive instruction from several schools and tutors during the course of his elementary education. Around the age of eight he was sent to a country school in [[Alphington, Devon|Alphington]] near [[Exeter]] to recover from a life-threatening fever. His parents ordered that his "brain was not to be taxed too much" and Babbage felt that "this great idleness may have led to some of my childish reasonings." For a short time he attended King Edward VI Grammar School in [[Totnes]], [[Devon|South Devon]], but his health forced him back to private tutors for a time.<ref>{{cite book | last = Moseley | first = Maboth | title = Irascible Genius, The Life of Charles Babbage | publisher = Henry Regnery Company (Chicago) | year = 1964 | page = 39 }}</ref> He then joined a 30-student Holmwood academy, in Baker Street, Enfield, Middlesexy under Reverend Stephen Freeman. The academy had a well-stocked library that prompted Babbage's love of mathematics. He studied with two more private tutors after leaving the academy. Of the first, a clergyman near [[Cambridge]], Babbage said, "I fear I did not derive from it all the advantages that I might have done." The second was an Oxford tutor from whom Babbage learned enough of the Classics to be accepted to Cambridge.


Babbage arrived at [[Trinity College, Cambridge]] in October 1810. He had read extensively in [[Leibniz]], [[Joseph Louis Lagrange]], [[Thomas Simpson]], and [[Lacroix]] and was seriously disappointed in the mathematical instruction available at Cambridge. In response, he, [[John Herschel]], [[George Peacock]], and several other friends formed the [[Analytical Society]] in 1812. Babbage, Herschel and Peacock were also close friends with future judge and patron of science [[Edward Ryan]]. Ultimately, Babbage and Ryan married sisters.<ref name="wilkes">Wilkes (2002) ''p.''355</ref>
===SmithKline Beecham===
In 1843, Thomas Beecham launched his [[Beecham's Pills]] laxative in England giving birth to the '''Beecham Group'''.<ref name="history"/> [[Beecham (pharmaceutical company)|Beechams]] opened its first factory in [[St Helens, Merseyside|St Helens]], [[Lancashire]], England for rapid production of medicines in 1859. By the 1960s it was extensively involved in pharmaceuticals.
[[Image:GSK HQ.jpg|thumb|right|The GSK Headquarters in [[Brentford]].]]


In 1812 Babbage transferred to [[Peterhouse, Cambridge]]. He was the top mathematician at Peterhouse, but failed to graduate with honors. He instead received an honorary degree without examination in 1814.
In 1830, John K. Smith opened its first pharmacy in Philadelphia.<ref name="history"/> Subsequently, in 1891, '''Smith, Kline and Company''' merged with French, Richard and Company.<ref name="history"/> It changed its name to [[SmithKline & French|Smith Kline & French Laboratories]] as it focused more on research in 1929. Years later, Smith Kline & French Laboratories opened a new laboratory in [[Philadelphia]]; it then bought Norden Laboratories, a business doing research into animal health.


===Marriage, family, death===
Smith Kline & French Laboratories bought [[Recherche et Industrie Thérapeutiques]] ([[Belgium]]) in 1963 to order to focus on vaccines.<ref name="history"/> The Company started to expand globally buying seven laboratories in Canada and the US in 1969. In 1982, it bought Allergan, a manufacturer of eye and skincare products.<ref name="history"/> The Company merged with Beckman Inc. later that year and then changed its name to SmithKline Beckman.<ref name="history"/>
[[Image:Babbage Charles grave.jpg|thumb|right|Grave of Charles Babbage at [[Kensal Green Cemetery]]]]


On July 25, 1814, Babbage married Georgiana Whitmore at St. Michael's Church in Teignmouth, Devon. The couple lived at [[Dudmaston Hall]]<ref>[http://www.visitbritain.co.uk/Attraction/Bridgnorth/Historic-House-or-Palace/157092/Dudmaston-Hall.htm Attraction information for Dudmaston Hall: VisitBritain<!-- Bot generated title -->]</ref>, Shropshire (where Babbage engineered the central heating system), before moving to 5 Devonshire Street, Portland Place, London.
In 1988, SmithKline Beckman bought its biggest competitor, International Clinical Laboratories,<ref name="history"/> and in 1989 merged with Beecham to form '''SmithKline Beecham''' plc.<ref name="history"/> The headquarters of the Company were then moved to England. To expand research & development in the US, SmithKline Beecham bought a new research center in 1995. Another new research centre at New Frontiers Science Park in Harlow, England was opened in 1997. But the main centre of focus operates in Dumfriesshire, Scotland.


Charles and Georgiana had eight children<ref>{{cite web | url = http://www.bavidge.co.uk/Babbage%20Family%20Tree%202005,%20InternetTree/wc03/wc03_074.htm | title = Babbage Family Tree 2005 | author = Valerie Bavidge-Richardson | accessdate = 2007-10-22}}</ref>, but only three — Benjamin Herschel, Georgiana Whitmore, and Henry Prevost — survived to adulthood. Georgiana died in [[Worcester]] on September 1, 1827. Charles' father, wife, and at least two sons all died in 1827. These deaths caused Babbage to go into a mental breakdown which delayed the construction of his machines.
In 2001, Glaxo Wellcome and SmithKline Beecham merged to form GlaxoSmithKline.<ref>[http://www.telegraph.co.uk/money/main.jhtml?xml=/money/2000/12/27/cnsmit27.xml Pharmaceutical giants Glaxo and SmithKline finally merge] Daily Telegraph, 2001</ref>


His youngest son, Henry Prevost Babbage (1824-1918), went on to create six working difference engines based on his father's designs<ref>[http://www.computerhistory.org/babbage/henrybabbage/ Henry Prevost Babbage - The Babbage Engine | Computer History Museum<!-- Bot generated title -->]</ref>, one of which was sent to [[Howard H. Aiken]], pioneer of the [[Harvard Mark I]]. Henry Prevost's 1910 Analytical Engine Mill, previously on display at [[Dudmaston Hall]], is now on display at [[Science Museum (London) | the Science Museum]]<ref>[http://www.sciencemuseum.org.uk/objects/computing_and_data_processing/1896-58.aspx Science Museum - Home - Henry Babbage's Analytical Engine Mill, 1910<!-- Bot generated title -->]</ref>.
==Operations==
As the second largest pharmaceutical company in the world, based on net income, the company had sales of £22.7 billion and made a profit of £7.8 billion in 2007.<ref>[http://www.gsk.com/investors/reps07/annual-report-2007.pdf GSK Annual Report 2007]</ref> It employs around 110,000 people worldwide, including over 40,000 in sales and marketing. Its global headquarters are GSK House in [[Brentford]], [[London]], [[United Kingdom]], with its [[United States]] headquarters based in [[Philadelphia]] and its consumer products division based in the [[Pittsburgh]] suburb of Moon Township, [[Pennsylvania]]. The research and development division has major headquarters in South East England, Philadelphia and [[Research Triangle Park]] (RTP) in [[North Carolina]].


Charles Babbage died at age 79 on October 18, 1871, and was buried in London's [[Kensal Green Cemetery]]. According to Horsley, Babbage died "of renal inadequacy, secondary to cystitis."<ref>{{cite journal | author = Horsley, Victor | title = Description of the Brain of Mr. Charles Babbage, F.R.S | journal = Philosophical Transactions of the Royal Society of London. Series B, Containing Papers of a Biological Character | year = 1909 | volume = 200 | pages = 117 &ndash; 132 | url = http://journals.royalsociety.org/content/xl7210623532p738/?p=daaddfe06dca444eafad36aab95177ea&pi=1 | doi = 10.1098/rstb.1909.0003 <!--Retrieved from url by DOI bot--> | accessdate=2007-12-07 }}- subscription required</ref> In 1983 the autopsy report for Charles Babbage was discovered and later published by one of his descendants.<ref>{{cite journal | author = Babbage, Neville | title = Autopsy Report on the Body of Charles Babbage ("the father of the computer") | journal = Medical Journal of Australia | year = 1991 | volume = 154 | pages = |}}</ref><ref>{{cite journal | author = Williams, Michael R. | title = The "Last Word" on Charles Babbage | doi = 10.1109/85.728225<!--Retrieved from URL by DOI bot-->| journal = IEEE Annals of the History of Computing | year = 1998 | volume = 20 | pages = 10 &ndash; 14 | url = http://csdl2.computer.org/persagen/DLAbsToc.jsp?resourcePath=/dl/mags/an/&toc=comp/mags/an/1998/04/a4toc.xml&DOI=10.1109/85.728225accessdate=2007-12-07 }}- subscription required</ref> A copy of the original is also available.<ref>[http://www.scienceandsociety.co.uk/results.asp?X9=BABBAGE,%20CHARLES Postmortem report by John Gregory Smith, F.R.C.S. (anatomist)]</ref> Babbage's brain is preserved at the Science Museum in London.<ref>[http://blogtobelet.blogspot.com/ Babbage's brain]</ref><ref>[http://www.danyey.co.uk/london.php Babbage's brain]</ref>
The company is listed on the London and New York [[stock exchange]]s. The single largest market is in the [[United States]] (approximately 45% of revenue), although the company has a presence in almost 70 countries.


==Design of computers==
==Products==
Babbage sought a method by which mathematical tables could be calculated mechanically, removing the high rate of human error. Three different factors seem to have influenced him: a dislike of untidiness; his experience working on [[logarithm|logarithmic tables]]; and existing work on calculating machines carried out by [[Wilhelm Schickard]], [[Blaise Pascal]], and [[Gottfried Leibniz]]. He first discussed the principles of a calculating engine in a letter to Sir [[Humphry Davy]] in 1822.
In 2007, pharmaceutical sales accounted for £19.2 billion (or 85%) of GSK's total sales. Sales are based around a broad range of products with the most successful (starting with highest sales) being:


[[Image:BabbageDifferenceEngine.jpg|thumb|right|Part of Babbage's difference engine, assembled after his death by Babbage's son, using parts found in his laboratory.]]
* [[fluticasone/salmeterol]] [[Advair]] a combination of the bronchodilator [[salmeterol]] and the steroid [[fluticasone]] for treatment of [[asthma]].
* Other Products
* [[Avandia]] ([[rosiglitazone]]), a PPAR-gamma [[agonist]] anti diabetic. [[Avodart]], [[Avidart]], [[Avolve]], [[Duagen]], [[Dutagen]], [[Dutas]] ([[dutasteride]]), for hair loss in men.
* [[Boniva]], [[Bondronat]], / [[Bonviva]] ([[ibandronic acid]]), for [[osteoporosis]] co marketed by [[Roche Laboratories]].
* [[Lamictal]] ([[lamotrigine]]), an [[anticonvulsant]] used to treat various types of [[epilepsy]] and type I [[bipolar disorder]]
* [[Levitra]] ([[vardenafil]]), for (ED) [[erectile dysfunction]].
* [[Requip]] / [[Ropark]] ([[ropinirole]]), for (RLS) [[restless legs syndrome]].
* [[Valtrex]] / [[Zelitrex]] ([[valacyclovir]]), an antiviral drug used in the management of [[herpes simplex]] and [[herpes zoster]] (shingles) which is very useful in curing some fatal diseases.
* [[Imigran]] / [[Imitrex]] ([[sumatriptan]]), a triptan drug including a sulfonamide group for the treatment of [[migraine]]
* [[Flonase]] ([[Fluticasone]]), for treatment of [[asthma]].
* [[Coreg]] ([[carvedilol]]), a non-selective beta blocker indicated in the treatment of mild to moderate [[congestive heart failure]].
* [[Relenza]] ([[zanamivir]]), for [[Influenzavirus A]] and [[Influenzavirus B]].
* [[Seroxat]], [[Paxil]], [[ParoMerck]], [[Rexetin]], [[Aropax]], [[Parotin]] ([[Paroxetine]]), an [[SSRI]] [[anti-depressant]]. [[Amerge]] ([[naratriptan]]), a triptan drug including a sulfonamide group for the treatment of [[migrane]].
* [[Augmentin]], a combination anitbiotic containing [[Amoxicillin]] and [[Clavulanic acid]].
* [[Tykerb]] (lapatinib), a tyrosine kinase inhibitor for oral use.
* [[Veramyst]] (fluticasone), for treatment of asthma.
* [[Vesicare]] ([[solifenacin]]), for bladder control problems co marketed by [[Astellas Pharma]].
* [[Zantac]], / [[Zinetac]] ([[ranitidine]]),for heartburn.
* [[Serodus]] ([[piboserod]]), for receptor [[antagonist]].
The Consumer Healthcare portfolio contributed sales of £3.4 billion in 2007, in three main areas:
* OTC medicines (e.g. [[Panadol]], [[Zovirax]], [[orlistat|alli]], [[Nicoderm]])
* Oral care ([[Aquafresh]], [[Macleans]], [[Sensodyne]])
* Nutritional healthcare ([[Lucozade]], [[Ribena]], [[Horlicks]])


Babbage's engines were among the first mechanical computers, although they were not actually completed, largely because of funding problems and personality issues. He directed the building of some steam-powered machines that achieved some success, suggesting that calculations could be mechanized. Although Babbage's machines were mechanical and unwieldy, their basic architecture was very similar to a modern computer. The data and program memory were separated, operation was instruction based, the control unit could make conditional jumps and the machine had a separate [[Input/output|I/O]] unit.
==Work in the community==
For many years now GSK has been a leading contributor to a multinational government and industry alliance to rid the world of [[filariasis|lymphatic filariasis]] ([[elephantiasis]]). LF threatens over one billion people in 83 countries. Approximately 120 million people are infected with the parasites, 40 million of whom have clinical symptoms of the disease. The Global Alliance to Eliminate LF was formed with the support of the pharmaceutical companies GlaxoSmithKline and [[Merck & Co.|Merck]] to help countries with LF respond. GSK has donated over 440 million [[albendazole]] tablets to date, which serve as a cornerstone of the program.


===Difference engine===
Jean-Pierre (JP) Garnier, former CEO of GlaxoSmithKline added, “The Egyptian data shows that we can now eliminate a disease that has plagued the world for centuries. We remain committed to donating as much albendazole as required to eliminate this disabling disease, but ultimate success will depend on continued long-term commitments by all partners across the globe.”
{{Main|Difference engine}}
In Babbage’s time, numerical tables were calculated by humans who were called ‘computers’, meaning "one who computes", much as a conductor is "one who conducts". At Cambridge, he saw the high error-rate of this human-driven process and started his life’s work of trying to calculate the tables mechanically. He began in 1822 with what he called the difference engine, made to compute values of polynomial functions. Unlike similar efforts of the time, Babbage's difference engine was created to calculate a series of values automatically. By using the method of [[finite difference]]s, it was possible to avoid the need for multiplication and division.


[[Image:050114 2529 difference.jpg|thumb|left|220px|The [[Science Museum (London)|London Science Museum]]'s [[replica]] Difference Engine, built from Babbage's design.]]
In addition Glaxo has been short-listed for awards such as The Worldaware Business Award for its work to eliminate malaria in Kenya.<ref>[http://www.worldaware.org.uk/awards/awards1999/glaxo.html The Shell Technology for Development Award] Worldware Business Award</ref>


The first difference engine was composed of around 25,000 parts, weighed fifteen [[short ton|tons]] (13,600 kg), and stood {{Convert| 8|ft|m| 1|abbr=on}} high. Although he received ample funding for the project, it was never completed. He later designed an improved version, "Difference Engine No. 2", which was not constructed until 1989-1991, using Babbage's plans and 19th-century manufacturing tolerances. It performed its first calculation at the London Science Museum returning results to 31 digits, far more than the average modern pocket calculator.
GlaxoSmithKline recently donated money to the British flood appeal, and was ranked first on the 2006 UK Corporate Citizenship Index for donations.<ref>[http://www.icharter.org/list/corporate_citizenship/index.html UK Corporate Citizenship rankings]</ref>


==Global locations==
*Global Pharmaceutical Operations headquarters in [[Brentford]], [[United Kingdom]] with US operations based at Franklin Plaza in [[Philadelphia, Pennsylvania|Philadelphia]], [[Pennsylvania]] and [[Research Triangle Park, North Carolina|Research Triangle Park]], [[North Carolina]].
*Consumer Products headquarters in [[Moon Township, Pennsylvania|Moon Township]], [[Pennsylvania]] suburb of [[Pittsburgh]]
*Major [[R&D]] sites in [[Greenford]], United Kingdom; [[Stevenage]], United Kingdom; [[Harlow]], United Kingdom; [[Ware]], United Kingdom; [[Beckenham]], United Kingdom; [[Verona]], Italy; [[Zagreb]], Croatia; [[Evreux]], France; [[Research Triangle Park]], North Carolina; and Upper Merion and Collegeville, Pennsylvania
*Major centre for [[biopharmaceutical]] products in [[Belgium]] ([[Wavre]] and [[Rixensart]])
*New R&D centres in [[Shanghai]], China and [[Boston]], USA
[[Image:Glaxo ulverston.JPG|thumb|Factory in Ulverston]]
*Major manufacturing sites for prescription products in [[Irvine, North Ayrshire|Irvine]], United Kingdom; [[Ware]], United Kingdom; [[Evreux]], France; [[Montrose, Angus|Montrose]], United Kingdom; [[Barnard Castle]], United Kingdom; [[Crawley]], United Kingdom; [[Ulverston]], United Kingdom; [[Bristol, Tennessee|Bristol]], [[Tennessee]]; [[King of Prussia, Pennsylvania|King of Prussia]], [[Pennsylvania]]; [[Zebulon, North Carolina|Zebulon]], [[North Carolina]]; [[Cidra]], [[Puerto Rico]]; Jurong [[Singapore]]; [[Cork (city)|Cork]], [[Ireland]]; and [[Parma]], Italy.
*Major manufacturing sites for consumer products in [[Maidenhead]], United Kingdom; [[Dungarvan]], Ireland; [[Mississauga, Ontario|Mississauga]], [[Ontario]]; [[Aiken, South Carolina|Aiken]], [[South Carolina]]; [[Clifton, New Jersey|Clifton]], [[New Jersey]]; and [[St. Louis, Missouri|St. Louis]], [[Missouri]]
*GSK has a presence in 99 cities across 39 countries


==Corporate governance==
Current members of the [[board of directors]] of GlaxoSmithKline are:
*[[Chris Gent|Sir Christopher Gent]] (Non-Executive Chairman);
*[[Andrew Witty]] (Chief Executive Officer);
*[[Stephanie Burns|Dr Stephanie Burns]] (Non-Executive Director);
*[[Lawrence Culp]] (Non-Executive Director);
*[[Crispin Davis|Sir Crispin Davis]] (Non-Executive Director);
*[[Julian Heslop]] (Chief Financial Officer);
*[[Deryck Maughan|Sir Deryck Maughan]] (Non-Executive Director);
*[[Ian Prosser|Sir Ian Prosser]] (Senior Independent Non-Executive Director);
*[[Ronaldo Schmitz|Dr Ronaldo Schmitz]] (Non-Executive Director);
*[[Moncef Slaoui]] (Executive Director, Chairman, Research & Development);
*[[Robert Wilson (businessman)|Robert Wilson]] (Non-Executive Director);
*[[Daniel Podolsky|Dr Daniel Podolsky]] (Non-Executive Director);
*[[Tom De Swaan]] (Independent Non-Executive Director).


====Replicas====
On October 8, 2007 it was announced that Dr Garnier would be succeeded as Chief Executive by Mr [[Andrew Witty]]. Mr Witty, 43, has taken up the position in May 2008 and joined the Board.
Two full-scale modern replicas of the Difference Engine have been constructed by the London Science Museum. One is owned by the museum and the other, owned by technology millionaire [[Nathan Myhrvold]], went on exhibit at the [[Computer History Museum]]<ref>[http://www.computerhistory.org/babbage/ Overview - The Babbage Engine | Computer History Museum<!-- Bot generated title -->]</ref> in [[Mountain View, California]] on May 10, 2008. <ref>{{cite web | last = Shiels | first = Maggie | title = Victorian 'supercomputer' is reborn | url = http://news.bbc.co.uk/2/hi/technology/7391593.stm |access-date = 2008-05-11 }}</ref> It will remain there until April, 2009, after which it will move to Myhrvold's personal collection.<ref>{ url = http://www.computerhistory.org/babbage/ |access-date = 2008-09-26 }}</ref>


===Analytical engine===
David Stout, president of Pharmaceuticals operations, and Chris Viehbacher, president of the US Pharmaceuticals division, who lost out to Mr Witty in the succession race, might possibly quit the company. However it was reported in the UK press on 5 December that both executives would receive retention packages worth £2m in the form of shares over the next 2 to 3 years plus a small amount of cash to stay at GlaxoSmithKline.
{{Main|Analytical engine}}
Soon after the attempt at making the difference engine crumbled, Babbage started designing a different, more complex machine called the [[Analytical Engine]]. The engine is not a single physical machine but a succession of designs that he tinkered with until his death in 1871. The main difference between the two engines is that the Analytical Engine could be programmed using [[punch cards]]. He realized that programs could be put on these cards so the person had only to create the program initially, and then put the cards in the machine and let it run. The analytical engine would have used loops of [[Jacquard loom|Jacquard]]'s punched cards to control a mechanical calculator, which could formulate results based on the results of preceding computations. This machine was also intended to employ several features subsequently used in modern computers, including sequential control, branching, and looping, and would have been the first mechanical device to be [[Turing-complete]].


[[Ada Lovelace]], an impressive mathematician, and one of the few people who fully understood Babbage's ideas, created a program for the Analytical Engine. Had the Analytical Engine ever actually been built, her program would have been able to calculate a sequence of [[Bernoulli numbers]]. Based on this work, Lovelace is now widely credited with being the first [[programmer|computer programmer]].<ref>J. Fuegi and J. Francis, "Lovelace & Babbage and the creation of the 1843 'notes'." Annals of the History of Computing 25 #4 (Oct-Dec 2003): 19, 25. [http://dx.doi.org/10.1109/MAHC.2003.1253887 Digital Object Identifier]</ref> In 1979, a contemporary programming language was named [[Ada programming language|Ada]] in her honour. Shortly afterward, in 1981, a satirical article by Tony Karp in the magazine ''Datamation'' described the Babbage programming language as the "language of the future".<ref>{{cite web | title = Babbage - The language of the future | author = Karp, Tony | url = http://www.tlc-systems.com/babbage.htm | access-date = 2008-05-11 }}</ref>
On December 7, 2007, it was announced that Andrew Witty, CEO Designate, and Chris Viehbacher, President US Pharmaceuticals, have been appointed Executive Directors and will join the Board of the Company with effect from January 31, 2008. It was also announced that David Stout will leave the company in February 2008 after coming third in the competition to succeed JP Garnier.


=== Modern adaptations ===
Tachi Yamada resigned as head of research and development at GSK during 2007 to take up a position working for Bill Gates' charitable foundation. He was replaced by Moncef Slaoui.
While the abacus and mechanical calculator have been replaced by electronic calculators using [[microchips]], the recent advances in [[MEMS]] and [[nanotechnology]] have led to recent high-tech experiments in mechanical computation. The benefits suggested include operation in [http://findarticles.com/p/articles/mi_m0WVI/is_1999_Oct_11/ai_56912203/print high radiation or high temperature] environments.


These modern versions of mechanical computation were highlighted in the magazine [[The Economist]] in its special "end of the millennium" black cover issue in an article entitled [http://www.economist.com/diversions/millennium/displaystory.cfm?story_id=E1_PNQGVQ Babbage's Last Laugh] (requires paid subscription). The article highlighted work done at [[University of California Berkeley]] by [[Ezekiel Kruglick]]. In this [http://www-bsac.eecs.berkeley.edu/publications/search/zoom.php?urltimestamp=1042574398 Doctoral Dissertation]the researcher reports mechanical logic cells and architectures sufficient to implement the Babbage Analytical engine (see above) or any general logic circuit. Carry-shift digital adders and various logic elements are detailed as well as modern analysis on required performance for microscopic mechanical logic.
==Diversity==
GlaxoSmithKline was named one of the 100 Best Companies for Working Mothers in 2007 by Working Mother magazine<ref>[http://www.workingmother.com/web?service=vpage/859 Working mother]</ref> and was recognized by the International Charter for its efforts. GSK also received a perfect score of 100 percent from the ''[[Human Rights Campaign]]'' Foundation's 2008 ''[[Corporate Equality Index]]'', an annual report card of corporate America's treatment of gay, lesbian, bisexual, and transgender (GLBT) employees, customers and investors. GSK also supports employee diversity networks for groups such as ECN, PTPN, GLBT, AAA, etc.


==Other accomplishments==
==Controversy==
In 1824, Babbage won the [[Gold Medal of the Royal Astronomical Society]] "for his invention of an engine for calculating mathematical and astronomical tables."
*'''[[Paroxetine]] (Seroxat, Paxil)''' is an [[SSRI]] antidepressant released in 1992 by GlaxoSmithKline. In March 2004 the FDA ordered a black box warning placed on SSRI and other antidepressants, warning of the risk for potential suicidal thinking in children and adolescents. Since the FDA approved paroxetine in 1992, approximately 5,000 U.S. citizens have sued GSK. On January 29 2007, the [[BBC]] in the UK broadcast a fourth documentary in its 'Panorama' series about Seroxat.<ref>{{cite web|url=http://news.bbc.co.uk/1/hi/programmes/panorama/6291773.stm|title=Secrets of the drug trials|date=2007-01-29|accessdate=2007-08-15|publisher=[[BBC]]}}</ref>


From 1828 to 1839 Babbage was [[Lucasian Professor of Mathematics]] at Cambridge. He contributed largely to several scientific periodicals, and was instrumental in founding the Astronomical Society in 1820 and the Statistical Society in 1834. However, he dreamt of designing mechanical calculating machines.
*In November 2007, a [[United States Congressional committee]] released a report <ref>{{cite web|title=Committee staff report to the chairman and ranking member. Committee on Finance United States Senate. The intimidation of Dr John Buse and the diabetes drug Avandia. November 2007.|accessdate=2008-01-22|publisher=[[United States Congressional committee]]|url=http://www.senate.gov/~finance/press/Bpress/2007press/prb111507a.pdf}}</ref> describing intimidation of Dr [[John Buse]] ([[University of North Carolina at Chapel Hill]]<ref>{{cite web|url=http://www.unc.edu/depts/uncspeak/busejohn.html|title=Speakers at Carolina|accessdate=2008-01-22}}</ref><ref>{{cite web|url=http://www.diabetes.org/aboutus.jsp?WTLPromo=HEADER_aboutus|title=About the American Diabetes Association|publisher=[[American Diabetes Association]]}}</ref>) by GlaxoSmithKline over his concerns about the cardiovascular risks associated with the company's antidiabetes drug [[Rosiglitazone]] (Avandia).<ref>{{cite web|url=http://www.guardian.co.uk/business/2007/nov/22/pharmaceuticals.glaxosmithklinebusiness|publisher=[[The Guardian]]|title=GSK accused of trying to intimidate critic}}</ref>


<blockquote>“... I was sitting in the rooms of the Analytical Society, at Cambridge, my head leaning forward on the table in a kind of dreamy mood, with a table of logarithms lying open before me. Another member, coming into the room, and seeing me half asleep, called out, "Well, Babbage, what are you dreaming about?" to which I replied "I am thinking that all these tables" (pointing to the logarithms) "might be calculated by machinery. " </blockquote>
*In March 2006, [[California Attorney General]] [[Bill Lockyer]] announced that "GlaxoSmithKline (GSK) will pay $14 million to resolve allegations that state-government programs paid inflated prices for the firm’s anti-depressant drug Paxil because GSK engaged in patent fraud, antitrust violations and frivolous litigation to maintain a monopoly and block generic versions from entering the market."<ref>{{cite web|title=Attorney General Lockyer Announces $14 Million National Settlement with GlaxoSmithKline to Resolve Patent Fraud, Antitrust Allegations|url=http://www.ag.ca.gov/newsalerts/release.php?id=1279|publisher=[[California Attorney General]]}}</ref>


In 1837, responding to the ''[[Bridgewater Treatises]]'', of which there were eight, he published his ''Ninth Bridgewater Treatise'', ''"On the Power, Wisdom and Goodness of God, as manifested in the Creation"'', putting forward the thesis that God had the omnipotence and foresight to create as a divine legislator, making laws (or programs) which then produced species at the appropriate times, rather than continually interfering with ''[[ad hoc]]'' miracles each time a new species was required. The book is a work of [[natural theology]], and incorporates extracts from correspondence he had been having with [[John Herschel]] on the subject.
*At the [[Annual General Meeting|AGM]] on [[19 May]] [[2003]], GSK shareholders rejected a motion regarding a £22 million pay and benefits package for CEO, JP Garnier. This was the first time such a rebellion by shareholders against a major British company has occurred, but was regarded as a possible turning point against other so-called "[[wikt:fat cat|fat cat]]" deals within executive pay structure.


Babbage also achieved notable results in [[cryptography]]. He broke Vigenère's [[autokey cipher]] as well as the much weaker cipher that is called [[Vigenère cipher]] today. The autokey cipher was generally called "the undecipherable cipher", though owing to popular confusion, many thought that the weaker polyalphabetic cipher was the "undecipherable" one. Babbage's discovery was used to aid English military campaigns, and was not published until several years later; as a result credit for the development was instead given to [[Friedrich Kasiski]], a Prussian infantry officer, who made the same discovery some years after Babbage.<ref>{{Cite book | author=Kahn, David L. | authorlink= | coauthors= | title=The Codebreakers: The Story of Secret Writing | date=1996 | publisher=Scribner | location=New York | isbn=978-0-684-83130-5 | pages=}}
*The company and its shareholders have been targeted by [[animal rights]] activists because it is a customer of the controversial animal-testing company, [[Huntingdon Life Sciences]] (HLS).<ref>[[BBC]] – [http://news.bbc.co.uk/1/hi/business/4988858.stm ''"Glaxo 'won't be driven out of UK'"'']. 17 May 2006</ref> HLS has been the subject since 1999 of an international campaign by [[Stop Huntingdon Animal Cruelty]] (SHAC) and the [[Animal Liberation Front]] (ALF), ever since footage shot covertly by [[People for the Ethical Treatment of Animals]] (PETA), which was shown on British television, showed staff punching, kicking, screaming and laughing at the animals in their care. On [[September 7]], [[2005]], the ALF detonated a bomb containing two litres of fuel and four pounds of explosives on the doorstop of the [[Buckinghamshire]] home of Paul Blackburn, GSK's corporate controller, causing minor damage.
</ref>


In 1838, Babbage invented the [[pilot (locomotive)|pilot]] (also called a cow-catcher), the metal frame attached to the front of locomotives that clears the tracks of obstacles. He also constructed a [[dynamometer car]] and performed several studies on [[Isambard Kingdom Brunel]]'s [[Great Western Railway]] in about 1838.<ref name="passages">{{cite web |url=http://books.google.com/books?id=2T0AAAAAQAAJ&printsec=frontcover&dq=charles+babbage&as_brr=1#PPR3,M2 |title=Babbage, Charles - "Passages from the Life of a Philosopher", page 317-318.}}</ref> Babbage's eldest son, Benjamin Herschel Babbage, worked as an engineer for Brunel on the railways before emigrating to Australia in the 1850s<ref name=BBH>{{cite web |url=http://www.asap.unimelb.edu.au/bsparcs/biogs/P000074b.htm |title=Babbage, Benjamin Herschel - Bright Sparcs Biographical entry |format= |work= |accessdate=2008-05-15}}</ref>
*In November 2005, AIDS Healthcare Foundation accused the company of boosting its short-term monopoly profit by not increasing production of the anti-[[AIDS]] drug [[AZT]] despite a surge in demand, hence creating a shortage that affected many AIDS patients in Africa. GSK announced that it had halted clinical trials of the CCR5 entry inhibitor, aplaviroc (GW873140), in HIV-infected, treatment-naive patients because of concerns about severe hepatotoxicity.<ref>[http://aids-clinical-care.jwatch.org/cgi/content/full/2005/928/1 Trials of Aplaviroc Halted in Treatment-Naive Patients] Journal Watch September 15, 2005</ref> In June of 2006 GSK said it was further cutting, by about 30%, the not-for-profit prices it charges for some of these medicines in the world's poorest countries.<ref>[http://pubs.acs.org/cen/news/84/i23/8423Glaxo.html Glaxo Will Cut AIDS Drug Prices For Poor Nations] Chemical & Engineering News. June 1, 2006</ref>


Babbage also invented an [[ophthalmoscope]], but although he gave it to a physician for testing it was forgotten, and the device only came into use after being independently invented by [[Hermann von Helmholtz]].<ref>[http://www.discoveriesinmedicine.com/Ni-Ra/Ophthalmoscope.html Medical Discoveries, Ophthalmoscope]</ref> <!-- it's in the BBC article but looks fanciful -- is also credited with the invention of [[Standard gauge|standard railroad gauge]], uniform [[penny post|postal rates]], [[occulting light]]s for lighthouses, the [[heliograph]],[http://news.bbc.co.uk/2/hi/technology/7391593.stm Victorian 'supercomputer' is reborn - BBC article]-->
===Legal===
In 2003 GSK signed a corporate integrity agreement and paid $88 million in a civil fine for overcharging [[Medicaid]] for the antidepressant [[Paxil]], and nasal-allergy spray [[Flonase]]. Later that year GSK also ran afoul of the [[Internal Revenue Service]] (IRS) and was facing a demand for $7.8 billion in backdated taxes and interest, the highest in IRS history.


Babbage twice stood for Parliament as a candidate for the borough of [[Finsbury]]. In 1832 he came in third among five candidates, but in 1834 he finished last among four.<ref>{{cite book | author = Crowther, J. G.| title = Scientific Types | year = 1968 | publisher = Barrie & Rockliff | location = London | pages = 266}}</ref><ref>{{cite book | author = Hyman Anthony | title = Charles Babbage, Pioneer of the Computer | year = 1982 | publisher = Prineton University Press | location = Princeton, New Jersey | pages = 82 &ndash; 87 }}</ref><ref>{{cite book | author = Moseley | title = Irascible Genius, The Life of Charles Babbage | year = 1964 | publisher = Henery Regnery | location = Chicago | pages = 120 &ndash; 121 }}- Note some confusion as to the dates.</ref>
On [[September 12]] [[2006]] GSK settled the largest tax dispute in IRS history agreeing to pay $3.1 billion. At issue in the case were Zantac and the other Glaxo Group heritage products sold from 1989–2005. The case was about an area of taxation dealing with intracompany "transfer pricing"—determining the share of profit attributable to the US subsidiaries of GSK and subject to tax by the IRS. Taxes for large multi-divisional companies are paid to revenue authorities based on the profits reported in particular tax jurisdictions, so how profits were allocated among various legacy Glaxo divisions based on the functions they performed was central to the dispute in this case.<ref>[http://business.timesonline.co.uk/article/0,,13129-2353321,00.html GSK settles largest tax dispute in history for $3.1bn] Times UK Online Sept 12 2006</ref>


In [[On the Economy of Machine and Manufacture]], Babbage described what is now called the Babbage principle, which describes certain advantages with division of labour. Babbage noted that highly skilled - and thus generally highly paid - workers spend parts of their job performing tasks that are 'below' their skill level. If the labour process can be divided among several workers, it is possible to assign only high-skill tasks to high-skill and -cost workers and leave other working tasks to less-skilled and paid workers, thereby cutting labour costs. This principle was criticised by [[Karl Marx]] who argued that it caused labour segregation and contributed to [[Social alienation|alienation]]. The Babbage principle is an inherent assumption in [[Frederick Winslow Taylor]]'s [[scientific management]].
In February 2007, the Serious Fraud Office in the UK launched an investigation into allegations of GSK being involved in the discredited oil-for-food sanctions regime in Iraq. They are accused of paying bribes to Saddam Hussein's regime.<ref>[http://www.guardian.co.uk/Iraq/Story/0,,2012485,00.html Guardian Unlimited February 14, 2007]</ref>


====Paroxetine====
==Eccentricities==
On [[December 22]] [[2006]], a US court decided in Hoorman, et al. v. SmithKline Beecham Corp that individuals who purchased [[Paxil]](R) or Paxil CR(TM) ([[paroxetine]]) for a minor child may be eligible for benefits under a $63.8 million Proposed Settlement.<ref>[http://www.paxilpediatricsettlement.com/ Pediatric Settlement] Paxil Pediatric Settlement Web site</ref>
The lawsuit stemmed from a consumer advocate protest against Paroxetine manufacturer GSK. Since the FDA approved paroxetine in 1992, approximately 5,000 U.S. citizens – and thousands more worldwide – have sued GSK. Most of these people feel they were not sufficiently warned in advance of the drug's side effects and addictive properties.


* Babbage once counted all the broken panes of glass of a factory, publishing in 1857 a "Table of the Relative Frequency of the Causes of Breakage of Plate Glass Windows": Of 464 broken panes, 14 were caused by "drunken men, women or boys".<ref>
According to the Paxil Protest website,<ref>[http://www.paxilprotest.com Paxil Protest Site]</ref>, hundreds more lawsuits have been filed against GSK. The Paxil Protest website was launched August 8, 2005 to offer both information about the protest and information on Paxil previously unavailable to the public. Just three weeks after its launch, the site received more than a quarter of a million hits. The original Paxil Protest website was removed from the internet in 2006. It is understood that the action to take down the site was undertaken as part of a confidentiality agreement or 'gagging order' which the owner of the site entered into as part of a settlement of his action against GlaxoSmithKline. (However, in March 2007, the website Seroxat Secrets<ref>[http://seroxatsecrets.wordpress.com/2007/03/03/the-paxil-protest-time-machine/ Seroxat Secrets]</ref> discovered that an archive of Paxil Protest site <ref>[http://web.archive.org/web/20060519170044/http://paxilprotest.com/ Paxil Protest]</ref> was still available on the internet via Archive.org) Gagging orders are common in such cases and can extend to documents that defendants wish to remain hidden from the public. However in some cases, such documents can become public at a later date, such as those made public by Dr. Peter Breggin in February of 2006.<ref>[http://www.breggin.com/courtfiling.pbreggin.2006.html A press release by Dr. Peter Breggin]</ref>


{{cite journal | title = Table of the Relative Frequency of Occurrence of the Causes of Breaking of Plate Glass Windows | author = Babbage, Charles | journal = Mechanics Magazine | year = 1857 | volume = 66 | pages = 82}}</ref><ref>{{cite book |author = Babbage, Charles | title = The Works of Charles Babbage, Volume V | year = 1989 | publisher = William Pickering | location = London | page = 137 | editor = Martin Campbell}}</ref><ref>See [http://books.google.com/books?vid=OCLC05633593&id=cScKAAAAIAAJ&pg=PA417&lpg=PA417&dq=Table+of+the+Relative+Frequency+of+the+Causes+of+Breakage+of+Plate+Glass+Windows this web site] for Babbage's table of causes of broken glass panes.</ref>
In January 2007, according to the Seroxat Secrets website,<ref>[http://seroxatsecrets.wordpress.com seroxat secrets website]</ref> the national group litigation in the United Kingdom, on behalf of several hundred people who allege withdrawal reactions through their use of the drug Seroxat, against GlaxoSmithKline plc, moved a step closer to the High Court in London, with the confirmation that Public Funding had been reinstated following a decision by the Public Interest Appeal Panel. The issue at the heart of this particular action claims Seroxat is a defective drug in that it has a propensity to cause a withdrawal reaction. Hugh James Solicitors have confirmed this news.<ref>[http://www.hughjames.com/lifestyle/groupactions/seroxt.html Hugh James Solicitors seroxat news]</ref>


* Babbages's distaste for commoners ("the Mob") included writing "Observations of Street Nuisances" in 1864, as well as tallying up 165 "nuisances" over a period of 80 days. He especially hated [[busking|street music]], and in particular the music of [[organ grinder]]s, against whom he railed in various venues. The following quotation is typical:
In March 2008 The Medicines and Healthcare Products Regulatory Agency concluded that GSK should have warned of the possible ill effects of taking Seroxat a lot sooner<ref>[http://www.mirror.co.uk/news/topstories/2008/03/07/suicide-pills-firm-slammed-89520-20343028/ 'Suicide' pills firm slammed]</ref>. GSK could not be prosecuted under the old legislation, but the law has now been changed.


:: ''It is difficult to estimate the misery inflicted upon thousands of persons, and the absolute pecuniary penalty imposed upon multitudes of intellectual workers by the loss of their time, destroyed by organ-grinders and other similar nuisances.''<ref>Babbage, Charles (1864) ''Passages from the Life of a Philosopher'', London: Longman, Green, Longman, Roberts, & Green, Chapter 26, page 342. ISBN 1-85196-040-6</ref>
====Ribena====
On March 27, 2007, GSK pleaded guilty in an Auckland District Court to 15 charges relating to misleading conduct brought against them under the Fair Trading Act by New Zealand's Commerce Commission. The charges related to a popular [[blackcurrant]] fruit drink [[Ribena]] which the company had led consumers to believe contained high levels of [[vitamin C]]. As part of a school science project, two 14-year-old school girls (Anna Devathasan and Jenny Suo) from [[Pakuranga College]] in [[Auckland]] ([[New Zealand]]) discovered that ready-to-drink juice sold in 100ml containers contained very little vitamin C. Approaches by the two teens to the company didn't resolve the issue but after the matter was publicised on a national consumer affairs television show ([[Fair Go]]) the matter came to the attention of the Commerce Commission (a government funded 'consumer watch-dog'). The commission's testing found that ready-to-drink Ribena contained no detectable vitamin C.


* Babbage once contacted the poet [[Alfred Tennyson]] in response to his poem [[Alfred Tennyson, 1st Baron Tennyson#Partial_list_of_works|"The Vision of Sin"]]. Babbage wrote, "In your otherwise beautiful poem, one verse reads,
The company was fined $217,000 for the 15 charges. The number of charges was reduced from 88 and covered a period from March 2002 to March 2006. GSK maintains that it did not intend to mislead consumers and that the advertising claims were based on testing procedures that have since been changed. It was ordered to run an advertising campaign to provide the facts after it admitted misleading the public about the vitamin C component in its Ribena drink. Through its lawyer, Adam Ross, the company accepted Commerce Commission allegations that claims that ready-to-drink Ribena contained 7mg of vitamin C per 100ml, or 44 per cent of the recommended daily intake, were incorrect. The company also agreed television advertising claiming the blackcurrants in Ribena had four times the vitamin C of oranges, while literally true, were likely to mislead consumers about the relative levels of vitamin C in Ribena.<ref>[http://www.nzherald.co.nz/section/1/story.cfm?c_id=1&objectid=10431253 Judge orders Ribena to fess up]</ref>


:: ''Every moment dies a man,''
==See also==
:: ''Every moment one is born.''
* [[Recherche et Industrie Thérapeutiques]] (R.I.T.)
* [[Quest Diagnostics]]


: ... If this were true, the population of the world would be at a standstill. In truth, the rate of birth is slightly in excess of that of death. I would suggest [that the next version of your poem should read]:
==References==
{{Reflist}}


:: ''Every moment dies a man,''
==External links==
:: ''Every moment 1 1/16 is born.''
*[http://www.gsk.com/about/history.htm Historical timeline including mergers that led to GlaxoSmithKline]
*[http://www.asia-manufacturing.com/perspectives_article.php?itemID=4gsk-corporate%20social%20responsibility-csr_report-GlaxoSmithKline GSK Providing Answers To Corporate Social Responsibility Questions], Apr 01 2008, Asia Manufacturing Pharma
*[http://www.hoovers.com/glaxosmithkline/--ID__41781--/free-co-factsheet.xhtml Hoovers profile]
*[http://www.lexdon.com/profile/GlaxoSmithKline_PLC/gsk.html Lexdon Business Library profile]
*[[Financial Times]] [http://briefings.ft.com/company/news.html?extelID=00044814&query=UK:GSK&region=&industry= Quote, profile & news]
*[[London Stock Exchange]] [http://www.londonstockexchange.com/en-gb/pricesnews/prices/System/DetailedPrices.htm?sym=GB0009252882GBGBXSET10925288GSK Quote, regulatory filings & news]
*[[New York Stock Exchange]] [http://www.nyse.com/about/listed/lcddata.html?ticker=GSK Quote, profile, regulatory filings & news]
*[http://www.cervicalcancerinfo.co.uk GlaxoSmithKline promoting greater awareness to Cervical Cancer]


: Strictly speaking, the actual figure is so long I cannot get it into a line, but I believe the figure 1 1/16 will be sufficiently accurate for poetry."<ref>See {{cite book | author = Swade, Doron | title = The Difference Engine | year = 2000 | publisher = Viking | location = New York | pages = 77}}</ref>
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== Quotations ==
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{{cquote|On two occasions I have been asked, &ndash; "Pray, Mr. Babbage, if you put into the machine wrong figures, will the right answers come out?" In one case a member of the [[House of Lords|Upper]], and in the other a member of the [[House of Commons of the United Kingdom|Lower]] House put this question. I am not able rightly to apprehend the kind of confusion of ideas that could provoke such a question.<ref>Babbage, Charles (1864) ''Passages from the Life of a Philosopher'', London: Longman, Green, Longman, Roberts, & Green, Chapter 5, page 67. ISBN 1-85196-040-6</ref>}}


== Commemoration==
Babbage has been commemorated by a number of references, as shown on [[Babbage (disambiguation)|this list]]. In particular, the [[Babbage (crater)|Babbage crater]] on the [[Moon]], and the [[Charles Babbage Institute]], an information technology archive and research center, were named after him. The large Babbage lecture theatre at [[Cambridge University]], used for undergraduate science lectures, commemorates his time at the university.


[[British Rail]] named a [[Class_60|locomotive]] after him in the 1990s as part of a program of naming locomotives after famous and significant scientists.
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* {{cite book | last = Babbage | first = Charles | title = A Comparative View of the Various Institutions for the Assurance of Lives | publisher = J. Mawman | year = 1826 | location = London| url = http://books.google.com/books?id=teGjS4XfpbMC&printsec=frontcover&dq=charles+babbage&as_brr=1#PPR1,M2}}
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* {{cite book | last = Babbage | first = Charles | title = Reflections on the Decline of Science in England, and on Some of Its Causes | publisher = B. Fellowes | year = 1830 | location = London| url = http://books.google.com/books?id=3bgPAAAAMAAJ&printsec=frontcover&dq=charles+babbage&as_brr=1#PPR1,M2}}
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* {{cite book | last = Babbage | first = Charles | title = On the Economy of Machinery and Manufactures | publisher = Charles Knight | year = 1835 | edition = 4 | location = London| url = http://books.google.com/books?id=wUQeMa0MFnkC&printsec=frontcover&dq=charles+babbage&as_brr=1#PPR1,M2}}
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* {{cite book | last = Babbage | first = Charles | title = The Ninth Bridgewater Treatise, a Fragment
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| publisher = John Murray | year = 1837 | location = London| url = http://books.google.com/books?id=RlgEAAAAQAAJ&printsec=frontcover&dq=charles+babbage&as_brr=1#PPP7,M2}}
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* {{cite book | last = Babbage | first = Charles | title = Table of the Logarithms of the Natural Numbers from 1 to 108000 | publisher = William Clowes and Sons | year = 1841 | location = London| url = http://books.google.com/books?id=teMGAAAAYAAJ&printsec=frontcover&dq=charles+babbage&as_brr=1#PPT8,M2}}
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* {{cite book | last = Babbage | first = Charles | title = The Exposition of 1851 | publisher = John Murray | year = 1851 | location = London| url = http://books.google.com/books?id=NZcBAAAAQAAJ&printsec=frontcover&dq=charles+babbage&as_brr=1#PPR3,M2}}
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* {{cite book | last = Babbage | first = Charles | title = Passages from the Life of a Philosopher | publisher = Longman | year = 1864 | location = London| url = http://books.google.com/books?id=2T0AAAAAQAAJ&printsec=frontcover&dq=charles+babbage&as_brr=1#PPR3,M2}}
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== References ==
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== External links ==
* [http://www-groups.dcs.st-and.ac.uk/~history/Mathematicians/Babbage.html Charles Babbage]
* [http://books.google.com/books?id=0CMYAAAAMAAJ&pg=PA57&dq=charles+babbage&as_brr=1#PPA57,M2 Mr. Charles Babbage] - obituary from [[The Times|''The Times'']] (1871)
* [http://www.cbi.umn.edu/about/babbage.html Charles Babbage Institute] - pages on "Who Was Charles Babbage?" including biographical note, description of Difference Engine No. 2, publications by Babbage, archival and published sources on Babbage, sources on Babbage and Ada Lovelace.
* [http://www.projects.ex.ac.uk/babbage/ The Babbage Pages]
* [http://www.satyam.com.ar/Babbage/en/index.html The Babbage Difference Engine] - an overview of how it works.
* [http://historical.library.cornell.edu/kmoddl/toc_babbage1.html "On a Method of Expressing by Signs the Action of Machinery"] , 1826. - Original edition
* {{NRA|P1076}}

{{Lucasian Professors of Mathematics}}

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[[Category:1791 births]]
[[Category:1871 deaths]]
[[Category:Alumni of Peterhouse, Cambridge]]
[[Category:Alumni of Trinity College, Cambridge]]
[[Category:Burials at Kensal Green Cemetery]]
[[Category:Computer pioneers]]
[[Category:English engineers]]
[[Category:English mathematicians]]
[[Category:English philosophers]]
[[Category:English Christians]]
[[Category:Fellows of the Royal Society of Edinburgh]]
[[Category:Fellows of the Royal Society]]
[[Category:Lucasian Professors of Mathematics]]

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Revision as of 19:54, 12 October 2008

Charles Babbage
Sketch by Henri Claudet, 1860s [1]
Born(1791-12-26)26 December 1791
Died18 October 1871(1871-10-18) (aged 79)
Nationality (legal)United Kingdom
Alma materPeterhouse, Cambridge
Scientific career
FieldsMathematics, analytic philosophy, computer science
InstitutionsTrinity College, Cambridge

Charles Babbage, FRS (December 26, 1791 London, England – October 18, 1871 Marylebone, London, England)[2] was an English mathematician, philosopher, inventor and mechanical engineer who originated the concept of a programmable computer. Parts of his uncompleted mechanisms are on display in the London Science Museum. In 1991 a perfectly functioning difference engine was constructed from Babbage's original plans. Built to tolerances achievable in the 19th century, the success of the finished engine indicated that Babbage's machine would have worked. Nine years later, the Science Museum completed the printer Babbage had designed for the difference engine, an astonishingly complex device for the 19th century. Babbage is credited with inventing the first mechanical computer that eventually led to more complex designs.

Biography

Birth

The birthplace of Charles Babbage is disputed, but he was most likely born in 44 Crosby Row, Walworth Road, London, England. A blue plaque on the junction of Larcom Street and Walworth Road commemorates the event.

Babbage's date of birth was given in his obituary in The Times as December 26, 1792. However, after the obituary appeared, a nephew wrote to say that Charles Babbage actually was born one year earlier, in 1791. The parish register of St. Mary's Newington, London, shows that Babbage was baptized on January 6, 1792, supporting a birth year of 1791.[3][4][5]

Charles' father, Benjamin Babbage, was a banking partner of the Praeds who owned the Bitton Estate in Teignmouth. His mother was Betsy Plumleigh Teape. In 1808, the Babbage family moved into the old Rowdens house in East Teignmouth, and Benjamin Babbage became a warden of the nearby St. Michael’s Church.

Education

His father's money allowed Charles to receive instruction from several schools and tutors during the course of his elementary education. Around the age of eight he was sent to a country school in Alphington near Exeter to recover from a life-threatening fever. His parents ordered that his "brain was not to be taxed too much" and Babbage felt that "this great idleness may have led to some of my childish reasonings." For a short time he attended King Edward VI Grammar School in Totnes, South Devon, but his health forced him back to private tutors for a time.[6] He then joined a 30-student Holmwood academy, in Baker Street, Enfield, Middlesexy under Reverend Stephen Freeman. The academy had a well-stocked library that prompted Babbage's love of mathematics. He studied with two more private tutors after leaving the academy. Of the first, a clergyman near Cambridge, Babbage said, "I fear I did not derive from it all the advantages that I might have done." The second was an Oxford tutor from whom Babbage learned enough of the Classics to be accepted to Cambridge.

Babbage arrived at Trinity College, Cambridge in October 1810. He had read extensively in Leibniz, Joseph Louis Lagrange, Thomas Simpson, and Lacroix and was seriously disappointed in the mathematical instruction available at Cambridge. In response, he, John Herschel, George Peacock, and several other friends formed the Analytical Society in 1812. Babbage, Herschel and Peacock were also close friends with future judge and patron of science Edward Ryan. Ultimately, Babbage and Ryan married sisters.[7]

In 1812 Babbage transferred to Peterhouse, Cambridge. He was the top mathematician at Peterhouse, but failed to graduate with honors. He instead received an honorary degree without examination in 1814.

Marriage, family, death

Grave of Charles Babbage at Kensal Green Cemetery

On July 25, 1814, Babbage married Georgiana Whitmore at St. Michael's Church in Teignmouth, Devon. The couple lived at Dudmaston Hall[8], Shropshire (where Babbage engineered the central heating system), before moving to 5 Devonshire Street, Portland Place, London.

Charles and Georgiana had eight children[9], but only three — Benjamin Herschel, Georgiana Whitmore, and Henry Prevost — survived to adulthood. Georgiana died in Worcester on September 1, 1827. Charles' father, wife, and at least two sons all died in 1827. These deaths caused Babbage to go into a mental breakdown which delayed the construction of his machines.

His youngest son, Henry Prevost Babbage (1824-1918), went on to create six working difference engines based on his father's designs[10], one of which was sent to Howard H. Aiken, pioneer of the Harvard Mark I. Henry Prevost's 1910 Analytical Engine Mill, previously on display at Dudmaston Hall, is now on display at the Science Museum[11].

Charles Babbage died at age 79 on October 18, 1871, and was buried in London's Kensal Green Cemetery. According to Horsley, Babbage died "of renal inadequacy, secondary to cystitis."[12] In 1983 the autopsy report for Charles Babbage was discovered and later published by one of his descendants.[13][14] A copy of the original is also available.[15] Babbage's brain is preserved at the Science Museum in London.[16][17]

Design of computers

Babbage sought a method by which mathematical tables could be calculated mechanically, removing the high rate of human error. Three different factors seem to have influenced him: a dislike of untidiness; his experience working on logarithmic tables; and existing work on calculating machines carried out by Wilhelm Schickard, Blaise Pascal, and Gottfried Leibniz. He first discussed the principles of a calculating engine in a letter to Sir Humphry Davy in 1822.

Part of Babbage's difference engine, assembled after his death by Babbage's son, using parts found in his laboratory.

Babbage's engines were among the first mechanical computers, although they were not actually completed, largely because of funding problems and personality issues. He directed the building of some steam-powered machines that achieved some success, suggesting that calculations could be mechanized. Although Babbage's machines were mechanical and unwieldy, their basic architecture was very similar to a modern computer. The data and program memory were separated, operation was instruction based, the control unit could make conditional jumps and the machine had a separate I/O unit.

Difference engine

In Babbage’s time, numerical tables were calculated by humans who were called ‘computers’, meaning "one who computes", much as a conductor is "one who conducts". At Cambridge, he saw the high error-rate of this human-driven process and started his life’s work of trying to calculate the tables mechanically. He began in 1822 with what he called the difference engine, made to compute values of polynomial functions. Unlike similar efforts of the time, Babbage's difference engine was created to calculate a series of values automatically. By using the method of finite differences, it was possible to avoid the need for multiplication and division.

The London Science Museum's replica Difference Engine, built from Babbage's design.

The first difference engine was composed of around 25,000 parts, weighed fifteen tons (13,600 kg), and stood 8 ft (2.4 m) high. Although he received ample funding for the project, it was never completed. He later designed an improved version, "Difference Engine No. 2", which was not constructed until 1989-1991, using Babbage's plans and 19th-century manufacturing tolerances. It performed its first calculation at the London Science Museum returning results to 31 digits, far more than the average modern pocket calculator.


Replicas

Two full-scale modern replicas of the Difference Engine have been constructed by the London Science Museum. One is owned by the museum and the other, owned by technology millionaire Nathan Myhrvold, went on exhibit at the Computer History Museum[18] in Mountain View, California on May 10, 2008. [19] It will remain there until April, 2009, after which it will move to Myhrvold's personal collection.[20]

Analytical engine

Soon after the attempt at making the difference engine crumbled, Babbage started designing a different, more complex machine called the Analytical Engine. The engine is not a single physical machine but a succession of designs that he tinkered with until his death in 1871. The main difference between the two engines is that the Analytical Engine could be programmed using punch cards. He realized that programs could be put on these cards so the person had only to create the program initially, and then put the cards in the machine and let it run. The analytical engine would have used loops of Jacquard's punched cards to control a mechanical calculator, which could formulate results based on the results of preceding computations. This machine was also intended to employ several features subsequently used in modern computers, including sequential control, branching, and looping, and would have been the first mechanical device to be Turing-complete.

Ada Lovelace, an impressive mathematician, and one of the few people who fully understood Babbage's ideas, created a program for the Analytical Engine. Had the Analytical Engine ever actually been built, her program would have been able to calculate a sequence of Bernoulli numbers. Based on this work, Lovelace is now widely credited with being the first computer programmer.[21] In 1979, a contemporary programming language was named Ada in her honour. Shortly afterward, in 1981, a satirical article by Tony Karp in the magazine Datamation described the Babbage programming language as the "language of the future".[22]

Modern adaptations

While the abacus and mechanical calculator have been replaced by electronic calculators using microchips, the recent advances in MEMS and nanotechnology have led to recent high-tech experiments in mechanical computation. The benefits suggested include operation in high radiation or high temperature environments.

These modern versions of mechanical computation were highlighted in the magazine The Economist in its special "end of the millennium" black cover issue in an article entitled Babbage's Last Laugh (requires paid subscription). The article highlighted work done at University of California Berkeley by Ezekiel Kruglick. In this Doctoral Dissertationthe researcher reports mechanical logic cells and architectures sufficient to implement the Babbage Analytical engine (see above) or any general logic circuit. Carry-shift digital adders and various logic elements are detailed as well as modern analysis on required performance for microscopic mechanical logic.

Other accomplishments

In 1824, Babbage won the Gold Medal of the Royal Astronomical Society "for his invention of an engine for calculating mathematical and astronomical tables."

From 1828 to 1839 Babbage was Lucasian Professor of Mathematics at Cambridge. He contributed largely to several scientific periodicals, and was instrumental in founding the Astronomical Society in 1820 and the Statistical Society in 1834. However, he dreamt of designing mechanical calculating machines.

“... I was sitting in the rooms of the Analytical Society, at Cambridge, my head leaning forward on the table in a kind of dreamy mood, with a table of logarithms lying open before me. Another member, coming into the room, and seeing me half asleep, called out, "Well, Babbage, what are you dreaming about?" to which I replied "I am thinking that all these tables" (pointing to the logarithms) "might be calculated by machinery. "

In 1837, responding to the Bridgewater Treatises, of which there were eight, he published his Ninth Bridgewater Treatise, "On the Power, Wisdom and Goodness of God, as manifested in the Creation", putting forward the thesis that God had the omnipotence and foresight to create as a divine legislator, making laws (or programs) which then produced species at the appropriate times, rather than continually interfering with ad hoc miracles each time a new species was required. The book is a work of natural theology, and incorporates extracts from correspondence he had been having with John Herschel on the subject.

Babbage also achieved notable results in cryptography. He broke Vigenère's autokey cipher as well as the much weaker cipher that is called Vigenère cipher today. The autokey cipher was generally called "the undecipherable cipher", though owing to popular confusion, many thought that the weaker polyalphabetic cipher was the "undecipherable" one. Babbage's discovery was used to aid English military campaigns, and was not published until several years later; as a result credit for the development was instead given to Friedrich Kasiski, a Prussian infantry officer, who made the same discovery some years after Babbage.[23]

In 1838, Babbage invented the pilot (also called a cow-catcher), the metal frame attached to the front of locomotives that clears the tracks of obstacles. He also constructed a dynamometer car and performed several studies on Isambard Kingdom Brunel's Great Western Railway in about 1838.[24] Babbage's eldest son, Benjamin Herschel Babbage, worked as an engineer for Brunel on the railways before emigrating to Australia in the 1850s[25]

Babbage also invented an ophthalmoscope, but although he gave it to a physician for testing it was forgotten, and the device only came into use after being independently invented by Hermann von Helmholtz.[26]

Babbage twice stood for Parliament as a candidate for the borough of Finsbury. In 1832 he came in third among five candidates, but in 1834 he finished last among four.[27][28][29]

In On the Economy of Machine and Manufacture, Babbage described what is now called the Babbage principle, which describes certain advantages with division of labour. Babbage noted that highly skilled - and thus generally highly paid - workers spend parts of their job performing tasks that are 'below' their skill level. If the labour process can be divided among several workers, it is possible to assign only high-skill tasks to high-skill and -cost workers and leave other working tasks to less-skilled and paid workers, thereby cutting labour costs. This principle was criticised by Karl Marx who argued that it caused labour segregation and contributed to alienation. The Babbage principle is an inherent assumption in Frederick Winslow Taylor's scientific management.

Eccentricities

  • Babbage once counted all the broken panes of glass of a factory, publishing in 1857 a "Table of the Relative Frequency of the Causes of Breakage of Plate Glass Windows": Of 464 broken panes, 14 were caused by "drunken men, women or boys".[30][31][32]
  • Babbages's distaste for commoners ("the Mob") included writing "Observations of Street Nuisances" in 1864, as well as tallying up 165 "nuisances" over a period of 80 days. He especially hated street music, and in particular the music of organ grinders, against whom he railed in various venues. The following quotation is typical:
It is difficult to estimate the misery inflicted upon thousands of persons, and the absolute pecuniary penalty imposed upon multitudes of intellectual workers by the loss of their time, destroyed by organ-grinders and other similar nuisances.[33]
Every moment dies a man,
Every moment one is born.
... If this were true, the population of the world would be at a standstill. In truth, the rate of birth is slightly in excess of that of death. I would suggest [that the next version of your poem should read]:
Every moment dies a man,
Every moment 1 1/16 is born.
Strictly speaking, the actual figure is so long I cannot get it into a line, but I believe the figure 1 1/16 will be sufficiently accurate for poetry."[34]

Quotations

On two occasions I have been asked, – "Pray, Mr. Babbage, if you put into the machine wrong figures, will the right answers come out?" In one case a member of the Upper, and in the other a member of the Lower House put this question. I am not able rightly to apprehend the kind of confusion of ideas that could provoke such a question.[35]

Commemoration

Babbage has been commemorated by a number of references, as shown on this list. In particular, the Babbage crater on the Moon, and the Charles Babbage Institute, an information technology archive and research center, were named after him. The large Babbage lecture theatre at Cambridge University, used for undergraduate science lectures, commemorates his time at the university.

British Rail named a locomotive after him in the 1990s as part of a program of naming locomotives after famous and significant scientists.

Publications

  • Babbage, Charles (1826). A Comparative View of the Various Institutions for the Assurance of Lives. London: J. Mawman.
  • Babbage, Charles (1830). Reflections on the Decline of Science in England, and on Some of Its Causes. London: B. Fellowes.
  • Babbage, Charles (1835). On the Economy of Machinery and Manufactures (4 ed.). London: Charles Knight.
  • Babbage, Charles (1837). The Ninth Bridgewater Treatise, a Fragment. London: John Murray.
  • Babbage, Charles (1841). Table of the Logarithms of the Natural Numbers from 1 to 108000. London: William Clowes and Sons.
  • Babbage, Charles (1851). The Exposition of 1851. London: John Murray.
  • Babbage, Charles (1864). Passages from the Life of a Philosopher. London: Longman.

References

  1. ^ NPG Ax18347
  2. ^ GRO Register of Deaths: DEC 1871 1a 383 MARYLEBONE - Charles Babbage, aged 79
  3. ^ Hyman, Charles (1982). Charles Babbage, Pioneer of the Computer. Princeton University Press. p. 5.
  4. ^ Moseley, Maboth (1964). Irascible Genius, The Life of Charles Babbage. Henry Regnery Company (Chicago). p. 29.
  5. ^ "The Late Mr. Charles Babbage, F.R.S." . The Times.
  6. ^ Moseley, Maboth (1964). Irascible Genius, The Life of Charles Babbage. Henry Regnery Company (Chicago). p. 39.
  7. ^ Wilkes (2002) p.355
  8. ^ Attraction information for Dudmaston Hall: VisitBritain
  9. ^ Valerie Bavidge-Richardson. "Babbage Family Tree 2005". Retrieved 2007-10-22.
  10. ^ Henry Prevost Babbage - The Babbage Engine | Computer History Museum
  11. ^ Science Museum - Home - Henry Babbage's Analytical Engine Mill, 1910
  12. ^ Horsley, Victor (1909). "Description of the Brain of Mr. Charles Babbage, F.R.S". Philosophical Transactions of the Royal Society of London. Series B, Containing Papers of a Biological Character. 200: 117–132. doi:10.1098/rstb.1909.0003. Retrieved 2007-12-07.- subscription required
  13. ^ Babbage, Neville (1991). "Autopsy Report on the Body of Charles Babbage ("the father of the computer")". Medical Journal of Australia. 154. {{cite journal}}: Cite has empty unknown parameter: |1= (help)
  14. ^ Williams, Michael R. (1998). "The "Last Word" on Charles Babbage". IEEE Annals of the History of Computing. 20: 10–14. doi:10.1109/85.728225.- subscription required
  15. ^ Postmortem report by John Gregory Smith, F.R.C.S. (anatomist)
  16. ^ Babbage's brain
  17. ^ Babbage's brain
  18. ^ Overview - The Babbage Engine | Computer History Museum
  19. ^ Shiels, Maggie. "Victorian 'supercomputer' is reborn". Retrieved 2008-05-11.
  20. ^ { url = http://www.computerhistory.org/babbage/ |access-date = 2008-09-26 }}
  21. ^ J. Fuegi and J. Francis, "Lovelace & Babbage and the creation of the 1843 'notes'." Annals of the History of Computing 25 #4 (Oct-Dec 2003): 19, 25. Digital Object Identifier
  22. ^ Karp, Tony. "Babbage - The language of the future". Retrieved 2008-05-11.
  23. ^ Kahn, David L. (1996). The Codebreakers: The Story of Secret Writing. New York: Scribner. ISBN 978-0-684-83130-5. {{cite book}}: Cite has empty unknown parameter: |coauthors= (help)
  24. ^ "Babbage, Charles - "Passages from the Life of a Philosopher", page 317-318".
  25. ^ "Babbage, Benjamin Herschel - Bright Sparcs Biographical entry". Retrieved 2008-05-15.
  26. ^ Medical Discoveries, Ophthalmoscope
  27. ^ Crowther, J. G. (1968). Scientific Types. London: Barrie & Rockliff. p. 266.
  28. ^ Hyman Anthony (1982). Charles Babbage, Pioneer of the Computer. Princeton, New Jersey: Prineton University Press. pp. 82–87.
  29. ^ Moseley (1964). Irascible Genius, The Life of Charles Babbage. Chicago: Henery Regnery. pp. 120–121.- Note some confusion as to the dates.
  30. ^ Babbage, Charles (1857). "Table of the Relative Frequency of Occurrence of the Causes of Breaking of Plate Glass Windows". Mechanics Magazine. 66: 82.
  31. ^ Babbage, Charles (1989). Martin Campbell (ed.). The Works of Charles Babbage, Volume V. London: William Pickering. p. 137.
  32. ^ See this web site for Babbage's table of causes of broken glass panes.
  33. ^ Babbage, Charles (1864) Passages from the Life of a Philosopher, London: Longman, Green, Longman, Roberts, & Green, Chapter 26, page 342. ISBN 1-85196-040-6
  34. ^ See Swade, Doron (2000). The Difference Engine. New York: Viking. p. 77.
  35. ^ Babbage, Charles (1864) Passages from the Life of a Philosopher, London: Longman, Green, Longman, Roberts, & Green, Chapter 5, page 67. ISBN 1-85196-040-6

External links