1-aminopropan-2-ol

Structural formula
Simplified structural formula without stereochemistry
General
Surname	1-aminopropan-2-ol
other names	1-amino-2-propanol Isopropanolamine MIPA Monoisopropanolamine 2-hydroxypropylamine ISOPROPANOLAMINE ( INCI ) ( RS ) -1-aminopropan-2-ol (±) -1-aminopropan-2-ol
Molecular formula	C 3 H 9 NO
Brief description	colorless liquid with an ammonia-like odor
External identifiers / databases
CAS number 78-96-6 ( racemate ) EC number 201-162-7 ECHA InfoCard 100.001.057 PubChem 4th ChemSpider 3 Wikidata Q161580
properties
Molar mass	75.11 g mol −1
Physical state	liquid
density	0.96 g cm −3 (20 ° C)
Melting point	1 ° C
boiling point	159 ° C
Vapor pressure	1.9 h Pa (20 ° C) 3.04 hPa (38 ° C) 3.5 hPa (40 ° C) 36.7 hPa (80 ° C) 240 hPa (120 ° C)
solubility	completely miscible with water soluble in ethanol and benzene
Refractive index	1.4478 (20 ° C)
safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary danger H and P phrases H: 314-302-312 P: 280-305 + 351 + 338-310
MAK	2 ml m −3 or 5.8 mg m −3
Toxicological data	2098 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

1-aminopropan-2-ol is an organic compound from the group of alkanolamines . It is a colorless liquid with a faint ammonia- like odor.

Extraction and presentation

1-aminopropan-2-ol can be obtained by reacting ammonia with propylene oxide .

${\displaystyle \mathrm {C_{3}H_{6}O+NH_{3}\longrightarrow C_{3}H_{9}NO} }$

The reaction product is obtained as a 1: 1 mixture of the enantiomers ( R ) -1-aminopropan-2-ol and ( S ) -1-aminopropan-2-ol, i.e. as a racemate .

properties

The colorless liquid with an ammonia-like odor turns brown on prolonged contact with air or iron . The vapors of 1-aminopropan-2-ol are heavier (2.59 times) than air.

1-aminopropan-2-ol forms flammable vapor-air mixtures at elevated temperatures. The compound has a flash point of 71 ° C. The explosion range is between 1.9 vol.% As the lower explosion limit (LEL) and 10.4 vol.% As the upper explosion limit (UEL). The ignition temperature is 335 ° C. The substance therefore falls into temperature class T2.

use

1-aminopropan-2-ol is used

• as an intermediate product for the production of dyes and medicinal products , pesticides and esters , amides and salts of higher molecular weight fatty acids , which are suitable as detergents , oil-in-water emulsifiers (in cosmetics) and the like
• as a stabilizer for textile waxes and solubilizer
• as a corrosion inhibitor in cooling lubricants

safety instructions

The vapors of 1-aminopropan-2-ol can form explosive mixtures with air at elevated temperatures (flash point 71 ° C).

See also

• Diisopropanolamine
• Triisopropanolamine
• 3-aminopropan-1-ol (structural isomer of 1-aminopropan-2-ol)

Individual evidence

1. ↑ Entry on ISOPROPANOLAMINE in the CosIng database of the EU Commission, accessed on February 25, 2020.
2. ↑ ^{a b c d e f g h i j k l m n o} Entry on 1-aminopropan-2-ol in the GESTIS substance database of the IFA , accessed on April 19, 2020(JavaScript required) .
3. ↑ ^{a b c d} Federal Institute for Occupational Safety and Health (BAUA): 1-aminopropan-2-ol (monoisopropanolamine, MIPA) , accessed on April 8, 2015 (PDF file; 206 kB).
4. ↑ Amino-2-propanol data sheet from Sigma-Aldrich , accessed on September 20, 2010 ( PDF ).
5. ↑ Entry on 1-aminopropan-2-ol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
6. ↑ Chemsafe database for safety-related parameters in explosion protection, PTB Braunschweig / BAM Berlin, accessed on April 19, 2020.