4- tert- butylphenol

Structural formula
General
Surname	4-tert-butylphenol
other names	1- tert- butyl-4-hydroxybenzene; p - tert -butylphenol;
Molecular formula	C 10 H 14 O
Brief description	white solid with a phenolic odor
External identifiers / databases
EC number	202-679-0
ECHA InfoCard	100.002.436
PubChem	7393
Wikidata	Q2306557
properties
Molar mass	150.22 g mol −1
Physical state	firmly
density	0.908 g cm −3 (20 ° C)
Melting point	100 ° C
boiling point	237 ° C
Vapor pressure	1.30 hPa (60 ° C)
solubility	very heavy in water (0.6 g l −1 at 20 ° C)
safety instructions
H and P phrases	H: 315-318-361f-410
	P: 201-281-301 + 330 + 331-305 + 351 + 338-310
Authorization procedure under REACH	Of particular concern: there are likely to be serious effects on the environment
MAK	Switzerland: 0.08 ml m −3 or 0.5 mg m −3
Toxicological data	2950 mg kg −1 ( LD 50 , rat , oral ) ; 2290 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

4- tert -Butylphenol is a chemical compound from the group of phenols .

Extraction and presentation

4- tert- butylphenol can be obtained by reacting phenol with tert- butanol in water at high pressure and temperatures around 250 ° C, whereby 2- tert- butylphenol is also formed. It can also be obtained by reacting phenol with isobutylene , which also produces 3- tert- butylphenol .

properties

4- tert- butylphenol is a flammable white solid with a phenol-like odor that is very sparingly soluble in water. It decomposes when heated, producing carbon monoxide and carbon dioxide .

use

4- tert- butylphenol is used in the manufacture of synthetic resins , mainly as a monomer for the manufacture of polycarbonates , phenolic resins and epoxy resins .

safety instructions

4- tert- butylphenol has depigmenting properties and can trigger allergies and leukoderma-like changes. There is evidence that 4- tert- butylphenol acts as a hormonal disruptor in the environment .

4- tert- butylphenol was included in the EU's ongoing action plan ( CoRAP ) in 2014 in accordance with Regulation (EC) No. 1907/2006 (REACH) as part of substance evaluation . The effects of the substance on human health and the environment are re-evaluated and, if necessary, follow-up measures are initiated. The reasons for the uptake of 4- tert- butylphenol were concerns about high (aggregated) tonnage and as a potential endocrine disruptor . The reassessment took place from 2014 and was carried out by Germany .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Entry on 4-tert-butylphenol in the GESTIS substance database of the IFA , accessed on November 9, 2019(JavaScript required) .
↑ ^a ^b OECD : Screening Information Dataset (SIDS) Initial Assessment Report (SIAR) for phenol, 4-tert-butyl- , accessed on April 19, 2015.
↑ Entry on 4-tert-butylphenol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on November 9, 2019. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Entry in the SVHC list of the European Chemicals Agency , accessed on July 16, 2019.
↑ Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 98-54-4 or 4-tert-butylphenol ), accessed on November 2, 2015.
^ U. Marcus Lindstrom: Organic Reactions in Water: Principles, Strategies and Applications . John Wiley & Sons, 2008, ISBN 0-470-99424-X , pp. 280 ( limited preview in Google Book search).
↑ George E. Totten: Handbook of Hydraulic Fluid Technology, Second Edition . CRC Press, 2011, ISBN 978-1-4200-8527-3 , pp. 840 ( limited preview in Google Book search).
↑ ^a ^b Umweltbundesamt: Substance assessments under REACH , accessed on April 20, 2015.
↑ J. Geier, H. Lessmann, u. a .: Effects of occupational sensitization to p-tert-butylphenol-formaldehyde resin ( Memento from May 14, 2018 in the Internet Archive ). In: Dermatology in Work and Environment , Volume 58, No. 4/2010, pp. 190–192, accessed on April 20, 2015.
↑ Community rolling action plan ( CoRAP ) of the European Chemicals Agency (ECHA): 4-tert-butylphenol , accessed on March 26, 2019.Template: CoRAP status / 2014

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Entry on 4-tert-butylphenol in the GESTIS substance database of the IFA , accessed on November 9, 2019(JavaScript required) .

[SIDS-2] OECD : Screening Information Dataset (SIDS) Initial Assessment Report (SIAR) for phenol, 4-tert-butyl- , accessed on April 19, 2015.

[CLP_100.002.436-3] Entry on 4-tert-butylphenol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on November 9, 2019. Manufacturers or distributors can expand the harmonized classification and labeling .

[SVHC-4] Entry in the SVHC list of the European Chemicals Agency , accessed on July 16, 2019.

[5] Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 98-54-4 or 4-tert-butylphenol ), accessed on November 2, 2015.

[U._Marcus_Lindstrom-6] U. Marcus Lindstrom: Organic Reactions in Water: Principles, Strategies and Applications . John Wiley & Sons, 2008, ISBN 0-470-99424-X , pp. 280 ( limited preview in Google Book search).

[George_E._Totten-7] George E. Totten: Handbook of Hydraulic Fluid Technology, Second Edition . CRC Press, 2011, ISBN 978-1-4200-8527-3 , pp. 840 ( limited preview in Google Book search).

[Umweltbundesamt-8] Umweltbundesamt: Substance assessments under REACH , accessed on April 20, 2015.

[9] J. Geier, H. Lessmann, u. a .: Effects of occupational sensitization to p-tert-butylphenol-formaldehyde resin ( Memento from May 14, 2018 in the Internet Archive ). In: Dermatology in Work and Environment , Volume 58, No. 4/2010, pp. 190–192, accessed on April 20, 2015.

[10] Community rolling action plan ( CoRAP ) of the European Chemicals Agency (ECHA): 4-tert-butylphenol , accessed on March 26, 2019.Template: CoRAP status / 2014