Aluminum orthophosphate

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Structural formula
Aluminum ion Phosphate ion
General
Surname Aluminum orthophosphate
other names

Berlinite

Molecular formula AlPO 4
Brief description

white, odorless solid

External identifiers / databases
CAS number
  • 7784-30-7 (anhydrous)
  • 22784-12-9 (tri hydrate )
EC number 232-056-9
ECHA InfoCard 100.029.142
PubChem 16693906
ChemSpider 58204
DrugBank DB14517
Wikidata Q419503
Drug information
ATC code

A02 AB03

Drug class

Antacid

properties
Molar mass 121.95 g mol −1
Physical state

firmly

density

2.57 g cm −3 

Melting point

> 1500 ° C

solubility

almost insoluble in water

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 315-319-335
P: 261-302 + 352-305 + 351 + 338-321-405-501
Thermodynamic properties
ΔH f 0

−1733.8 kJ / mol

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Aluminum orthophosphate , also called aluminum phosphate for short , is an aluminum salt that forms rhombic crystals . In this connection is aluminum as a triply positively charged cation (Al 3+ before) connected to the phosphate - anion (PO 4 3- ) in electrostatic stands interaction.

Occurrence

In nature, aluminum orthophosphate occurs as so-called berlinite , a colorless to light pink mineral that is found in the Urals and Sweden .

synthesis

Aluminum orthophosphate

The orthophosphate can be obtained from sodium phosphate and an aluminum salt solution, e.g. B .:

use

Aluminum orthophosphate is used as a flux in the manufacture of glasses , ceramics and glazes . In a mixture with calcium sulfate and sodium silicates it is known under the term cement .

Gels containing aluminum orthophosphate are used as antacids in medicine .

It is also used as an adjuvant in some vaccines , for example in the pneumococcal vaccine Synflorix or Prevnar 13 or as a combination for AS04 in hepatitis B and HPV vaccines . It is in a chemically amorphous form in which some OH groups have been replaced with phosphate groups. This leads to a large surface and absorption capacity. The isoelectric point of the commercially available adjuvant is in the range from 4.5 to 5.5.

Trade names

Aluminum phosphate is commercially available in Germany under the name Phosphalugel.

Individual evidence

  1. a b c data sheet aluminum orthophosphate from AlfaAesar, accessed on January 7, 2010 ( PDF )(JavaScript required) .
  2. a b c Entry on aluminum phosphate in the GESTIS substance database of the IFA , accessed on January 30, 2013(JavaScript required) .
  3. David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Standard Thermodynamic Properties of Chemical Substances, pp. 5-5.
  4. Synflorix. In: European Medicines Agency . September 17, 2018, accessed February 4, 2020 .
  5. ^ Prevenar 13. In: European Medicines Agency. March 26, 2020, accessed April 20, 2020 .
  6. H. Ronneberger: Adjuvants in human vaccines . In: H. Schöffl et al. (Ed.): Research without animal experiments 1996 . Springer, Vienna 1997, p. 218-223 , doi : 10.1007 / 978-3-7091-6833-2_28 .
  7. Ralf Wagner and Eberhard Hildt: Composition and mechanisms of action of adjuvants in approved viral vaccines . In: Federal Health Gazette . tape 62 , no. 4 , April 1, 2019, ISSN  1437-1588 , p. 462-471 , doi : 10.1007 / s00103-019-02921-1 .
  8. ^ Stanley A. Plotkin et al .: Plotkin's Vaccines . 7th edition. Elsevier, 2017, ISBN 978-0-323-35761-6 , pp. 64 ( elsevier.com ).