Benperidol

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Structural formula
Benperidol.svg
General
Non-proprietary name Benperidol
other names

4-fluoro-4- [4- (2-oxo-1-benzimidazolinyl) piperidino] butyrophenone ( IUPAC )

Molecular formula C 22 H 24 FN 3 O 2
External identifiers / databases
CAS number
EC number 218-172-2
ECHA InfoCard 100.016.521
PubChem 16363
ChemSpider 15521
DrugBank DB12867
Wikidata Q424412
Drug information
ATC code

N05 AD07

Drug class

Antipsychotic , butyrophenones

properties
Molar mass 381.44 g · mol -1
Physical state

firmly

Melting point

170-171.8 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 302 + 332-362
P: 263-260-261-301 + 312-304 + 340-501
Toxicological data

432 mg kg −1 ( LD 50 ,  mouse ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Benperidol is a drug from the group of butyrophenones , which is used in psychiatry as a neuroleptic to treat schizophrenia .

Since the approval for the somewhat more potent trifluperidol (former commercial preparation triperidol ) expired in mid-2005 , benperidol is the substance with the highest neuroleptic potency of all neuroleptics available in Europe .

Mechanism of action

Like the other highly potent butyrophenones, benperidol has a particularly strong affinity for the D 2 receptor . Its blocking effect on dopaminergic transmission in the basal ganglia is so strong that when benperidol is administered, the patient almost always experiences the typical side effects - such as the extrapyramidal syndrome , e.g. B. Akathisias , Dyskinesias , Parkinsonoids etc. - has to suffer. Therefore, a Benperidol application often makes the administration of anticholinergics such. B. Biperiden necessary, whose possible hallucinogenic effects can weaken the originally intended effect.

A dangerous complication is the potentially fatal Neuroleptic Malignant Syndrome , which occurs more frequently with benperidol than with other neuroleptics due to its high neuroleptic potency.

Therapeutic value

Because of its usually very pronounced undesirable effects, benperidol is now only considered a reserve drug in the treatment of schizophrenia , the use of which is steadily declining, especially since strong atypical neuroleptics such as olanzapine have become available.

Commercial preparations

Benperidol is available in Germany under the name Glianimon and as a generic.

See also

Individual evidence

  1. ↑ a b Entry on benperidol in the ChemIDplus database of the United States National Library of Medicine (NLM) .
  2. ↑ a b lgcstandards: Benperidol ( Memento from October 31, 2016 in the Internet Archive )