Cefacetrile
Structural formula | ||||||||||||||||||||||
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General | ||||||||||||||||||||||
Non-proprietary name | Cefacetrile | |||||||||||||||||||||
other names | ||||||||||||||||||||||
Molecular formula | C 13 H 13 N 3 O 6 S | |||||||||||||||||||||
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Drug information | ||||||||||||||||||||||
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Drug class | ||||||||||||||||||||||
Mechanism of action |
Disturbance of the cell wall synthesis of the bacteria |
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properties | ||||||||||||||||||||||
Molar mass | 339.32 g · mol -1 | |||||||||||||||||||||
Physical state |
firmly |
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Melting point |
168-170 ° C |
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solubility |
poor in water (2.43 mg l −1 ) |
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safety instructions | ||||||||||||||||||||||
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Toxicological data | ||||||||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Cefacetril is a semisynthetic antibiotic from the class of the cephalosporins of the first generation, which is used in veterinary medicine as an injection preparation for the treatment of infections . There are currently no veterinary medicinal products available in Germany that contain cefacetril as an active ingredient.
indication
Cefacetril is mainly used in cattle to treat udder infections.
Working principle
Cefacetril inhibits the build-up of the cell wall of bacteria by binding to specific penicillin-binding proteins within the bacterial cell wall and thus preventing the cell wall synthesis of the bacteria.
The antibiotic shows a high activity against gram-positive bacteria such as straphylococci and streptococci and less strong activity against gram-positive pathogens such as E. coli , Klebsiella and Salmonella . Cefacetril shows little or no activity against infections caused by Pseudomonas , Listeria and germs with resistance to penicillins and cephalosporins.
Application
Cefacetrile is parenterally administered, since oral only a small percentage of the active ingredient from the administration of the antibiotic digestive tract is taken.
Individual evidence
- ↑ a b c Entry on Cefacetrile in the DrugBank of the University of Alberta , accessed January 4, 2019.
- ↑ a b Data sheet Cefacetrile sodium from Sigma-Aldrich , accessed on January 4, 2019 ( PDF ).
- ↑ Entry on Cefacetril. In: Römpp Online . Georg Thieme Verlag, accessed on January 4, 2019.
- ↑ a b c d Cefacetrile Summary Report (2) . European Medicines Agency , Committee for Veterinary Medicinal Products. 2000. Retrieved January 4, 2019.