Mezzadri became a professional tennis player in 1983. The following year he reached a quarter-finals on the ATP World Tour for the first time in Florence . With Gianni Ocleppo he was in a double final for the first time in 1986. 1987 was his most successful year in professional tennis. He won his first and only individual title in Geneva by beating Tomáš Šmíd in the final ; He was also able to win two double titles, including the Masters tournament in Paris . Two more times he was in a double final. In the following two years he won two more double titles and took part in two other finals. In 1992 he was in the singles final of Charlotte , but lost to MaliVai Washington . He reached his highest ranking in the tennis world rankings in 1987 with position 26 in singles and 1988 with position 23 in doubles.
Mezzadri played 15 singles and five doubles games for the Swiss Davis Cup team between 1987 and 1991 , including defeating Henri Leconte in the first round match of the world group in 1988, which Switzerland lost 4-1 to France .