Dodin

Structural formula
	Nonionic presentation of the structural formula of the acetic acid salt
General
Surname	Dodin
other names	(Dodecylguanidine) acetate; Cyprex; Lauryl guanidine acetate; Bilobran; Melprex; Questuran; Carpene; Dodecylguanidine monoacetate;
Molecular formula	C 15 H 33 N 3 O 2
Brief description	colorless solid
External identifiers / databases
EC number	219-459-5
ECHA InfoCard	100.017.690
PubChem	17110
Wikidata	Q424835
properties
Molar mass	287.45 g mol −1
Physical state	firmly
Melting point	136 ° C
solubility	almost insoluble in water; soluble in alcohols and acids;
safety instructions
H and P phrases	H: 302-315-319-410
	P: 273-301 + 312 + 330-302 + 352-305 + 351 + 338
Toxicological data	660 mg kg −1 ( LD 50 , rat , oral ) ; 2100 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Dodine is a chemical compound from the group of guanidine salts .

Extraction and presentation

Dodine can be obtained by reacting dodecylamine hydrochloride with cyanamide and further reacting the intermediate product formed with sodium acetate . It is also possible to obtain it by reacting dodecyl chloride with sodium cyanide and ammonia .

properties

Dodine is a colorless solid that is insoluble in water. It decomposes when heated before it reaches the boiling point.

use

Dodin is a fungicide brought onto the market in 1957 , which also has a low curative effect. For example, it is used in apple cultivation against apple scab ( Venturia inaequalis ).

Admission

After it had not been approved for a few decades, the now patent-free active ingredient was approved again by the Agriphar company in 2007 .

In Germany, Austria and Switzerland there are approved plant protection products (e.g. syllite) that contain dodine.

In Switzerland, spinach has a relatively high maximum residue level of 8 milligrams of dodine per kilogram.

Individual evidence

↑ ^a ^b ^c ^d ^e Entry on Dodin in the GESTIS substance database of the IFA , accessed on January 8, 2020(JavaScript required) .

↑ ^a ^b Joint Meeting on Pesticide Residues (JMPR), Monograph for Dodine , accessed December 9, 2014.

↑ ^a ^b Dodin data sheet at Sigma-Aldrich , accessed on May 20, 2017 ( PDF ).

↑ Entry on Dodine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

↑ Thomas A. Unger: Pesticide synthesis handbook . 1996, ISBN 978-0-8155-1401-5 ( page 892 in the Google book search).

↑ Entry on Dodine in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on August 1, 2013.

↑ Horst Börner et al .: Plant diseases and plant protection . Springer-Verlag , Berlin, Heidelberg 2009, ISBN 978-3-540-49067-8 ( limited preview in the Google book search).

↑ NZPPS pesticide resistance management strategy. Retrieved March 19, 2019 .

↑ Corporate Magazine Agriphar Group ( Memento of February 4, 2015 in the Internet Archive ) June 2012.

^ Directorate-General for Health and Food Safety of the European Commission: Entry on Dodine in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 12, 2016.

↑ Ordinance of the EDI on the maximum levels for pesticide residues in or on products of plant and animal origin. In: admin.ch . Retrieved February 6, 2020 .

[GESTIS-1] Entry on Dodin in the GESTIS substance database of the IFA , accessed on January 8, 2020(JavaScript required) .

[WHO-2] Joint Meeting on Pesticide Residues (JMPR), Monograph for Dodine , accessed December 9, 2014.