Endrin

Structural formula
General
Surname	Endrin
other names	Hexachlorepoxyoctahydrobis (endomethylene) naphthalene; rel - (1 R , 4 S , 4a S , 5 S , 6 S , 7 R , 8 R , 8a R ) -1,2,3,4,10,10-hexachloro-6,7-epoxy-1, 4,4a, 5,6,7,8,8a-octahydro-1,4-endo-5,8-endodimethanonaphthalene; 3,4,5,6,13,13-hexachloro-10-oxapentacyclo [6.3.1.1 3,6 .0 2,7 .0 9,11 ] tridec-4-en;
Molecular formula	C 12 H 8 Cl 6 O
Brief description	white, crystalline solid
External identifiers / databases
EC number	200-775-7
ECHA InfoCard	100,000,705
PubChem	12358480
Wikidata	Q423354
properties
Molar mass	380.9 g mol −1
Physical state	firmly
density	1.77 g cm −3 (20 ° C)
Melting point	Decomposes at 245 ° C
solubility	practically insoluble in water (0.25 mg l −1 at 20 ° C)
safety instructions
H and P phrases	H: 300-311-410
	P: 264-273-280-301 + 310-312-501
MAK	DFG : 0.1 mg m −3 ; Switzerland: 0.05 mg m −3 ;
Toxicological data	3 mg kg −1 ( LD 50 , rat , oral ) ; 1.4 mg kg −1 ( LD 50 , mouse , oral ) ; 171 mg kg −1 ( LD Lo , male , oral ) ; 234 mg kg −1 ( LD Lo , woman , oral ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Endrin is an insecticide that was mainly used in cotton and grain cultivation . It was also used as a rodenticide to control voles (trade names: e.g. Mäuse-Kindrin, Fagazid-Vole remedy). However, this application has been prohibited since August 8, 1982.

Endrin is a powerful neurotoxin . In the body of humans and animals, endrin is less concentrated than the stereoisomeric dieldrin . The half-life in the soil can be up to twelve years. Endrin is very toxic to fish.

Analytical evidence

The chemical-analytical detection in environmental samples, food and animal feed is carried out after suitable sample preparation to separate the matrix and gas chromatographic separation of minor components by high-resolution mass spectrometry techniques such as flight mass spectrometry (Time-Of-Flight mass spectrometry).

Prohibition

In Stockholm Convention of 22 May 2001 for a worldwide ban on the manufacture, sale and use of twelve was persistent organic pollutants ( POP = persistent organic pollutants ) ratified. Among that " dirty dozen " is Endrin. Since May 17, 2004, following ratification by the 50th accession state, the Convention has gained global legal validity .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g Entry on Endrin in the GESTIS substance database of the IFA , accessed on February 13, 2017(JavaScript required) .
↑ Entry on Endrin in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 72-20-8 or Endrin ), accessed on September 19, 2019.
↑ ^a ^b ^c ^d Entry on endrin in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on July 28, 2019.
↑ Entry on Endrin. In: Römpp Online . Georg Thieme Verlag, accessed on March 22, 2015.
↑ Pesticides: Silent Spring . In: Der Spiegel . No. 21 , 1982, pp. 76-78 ( online ).
↑ Eric J. Reiner, Adrienne R. Boden, Tony Chen, Karen A. MacPherson and Alina M. Muscalu: Advances in the Analysis of Persistent Halogenated Organic Compounds . In: LC GC Europe . 23 (2010) 60-70.
↑ BMU : POPs - (Persistent Organic Pollutants) .
↑ General Directorate Health and Food Safety of the European Commission: Entry on Endrin in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 26, 2016.

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g Entry on Endrin in the GESTIS substance database of the IFA , accessed on February 13, 2017(JavaScript required) .

[CLP_100.000.705-2] Entry on Endrin in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[3] Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 72-20-8 or Endrin ), accessed on September 19, 2019.

[ChemID-4] Entry on endrin in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on July 28, 2019.

[5] Entry on Endrin. In: Römpp Online . Georg Thieme Verlag, accessed on March 22, 2015.

[6] Pesticides: Silent Spring . In: Der Spiegel . No. 21 , 1982, pp. 76-78 ( online ).

[Reiner-7] Eric J. Reiner, Adrienne R. Boden, Tony Chen, Karen A. MacPherson and Alina M. Muscalu: Advances in the Analysis of Persistent Halogenated Organic Compounds . In: LC GC Europe . 23 (2010) 60-70.

[8] BMU : POPs - (Persistent Organic Pollutants) .

[9] General Directorate Health and Food Safety of the European Commission: Entry on Endrin in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 26, 2016.