Georg Winterer

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Georg Winterer, 2020.

Georg Winterer (born July 9, 1961 in Hausach in the Black Forest ) is a German entrepreneur , neuroscientist and specialist in psychiatry and psychotherapy . He is an adjunct professor at Charité - Universitätsmedizin Berlin , where he heads the clinical neurosciences research group in the Experimental and Clinical Research Center (ECRC) of the Clinic for Anaesthesiology & Operative Intensive Care Medicine. He is the founder and managing director of the Berlin-based PI Solutions Group GmbH.

Career

Winterer studied human medicine , philosophy and German at the Free University of Berlin . He received his doctorate in 1991 with an experimental epidemiological work at the Institute for Medical Psychology and completed a specialist training from 1990 in neurology / intensive medicine , neurophysiology and psychiatry and in the emergency service at the Brandenburg State Hospital (Brandenburg an der Havel: 1990-92) and the Free University of Berlin .

From 1995 to 1997 he worked as a research assistant (W1) in the laboratory for psychophysiology at the Free University of Berlin (psychiatric clinic) as well as accompanying specialist outpatient and medical consultancy work. In 2001 Georg Winterer completed his habilitation with a thesis on the "Physiology of Prefrontal Function". As a Clinical Fellow and Fogarty Fellow of the Global Health Fellowship Program , he conducted research from 1997 to 2003 at the National Institutes of Health (NIMH / NIAAA) in Bethesda, USA .

At the NIMH ( Clinical Brain Disorder Branch , CBDB) he was head of the clinical research station / research outpatient department and sub-project leader of the National Schizophrenia Sibling Study . At the same time, he passed the three US state examinations (human medicine) and received the United States Permanent Resident Card (“Green Card”) in the Outstanding Scientist category . After his stay in the USA, Winterer returned to Germany for family reasons and worked as a senior physician in psychiatry at the University of Mainz .

In 2006, Vice-Rector Jürgen Schrader appointed Georg Winterer a lifetime W2 professor for psychiatry at the Clinic and Polyclinic for Psychiatry and Psychotherapy of the Heinrich Heine University in Düsseldorf , where he was the senior physician in charge of the clinic and head of the consultant psychiatry department at the university clinic.

From 2009 to 2012 he was a research group leader at the Cologne Center for Genomics (CCG) at the University of Cologne , and from 2006 to 2012 he was an Associate Scientist at the Research Center Jülich of the Helmholtz Association (Institute for Neurosciences). Georg Winterer has been a research group leader at the Experimental & Clinical Research Center at Charité - Universitätsmedizin Berlin (Campus Berlin-Buch) since 2012.

Research priorities

Georg Winterer's main focus is the risk prediction of the course of disease. His early publications are devoted to addiction research and schizophrenia ( electrophysiology , neuroimaging , pharmacology , genetics ). His more recent scientific publications focus on the deterioration of cognitive performance and neurodegeneration in critically ill elderly patients after surgery.

In the course of his earlier scientific work, Winterer discovered that in addiction disorders ( alcohol and tobacco ) a disturbed function of the frontal lobe (over-activation of the frontal lobe ) predicts an unfavorable course of the disease (especially relapse). In addition, Winterer discovered in more than ten years of research (1994-2007) that a disorder of the frontal brain function (reduced signal-to-noise ratio with increased noise during information processing) is associated with a (genetically) increased risk of schizophrenia. The corresponding studies are the basis of one to this day worldwide with the most frequently cited simulation model (Computational Neural Network Model) of impaired brain function in schizophrenia. Winterer is also the first to describe a risk signature (clinical, imaging, molecular) which increases the risk in older surgical patients of suffering from cognitive impairments after an operation, which in turn is associated with a significantly increased mortality (mortality) and considerable socio-economic costs.

Research projects

Georg Winterer currently heads two national and international research consortia at Charité - Universitätsmedizin Berlin .

The international research consortium “Biomarker Development for Postoperative Cognitive Impariment in the Elderly (BioCog)” was funded in the 7th Framework Program of the European Commission and is supported with funds from the Berlin Institute of Health (BIH). The aim of the world's largest clinical project on post-operative cognitive disorders to date is to enable a better prediction of the risk of acute and chronic post-operative cognitive impairments in older patients over 65 years of age with the help of clinical parameters , imaging methods and molecular examinations (biomarkers) . On this basis, an AI-supported application software (app) for risk prediction in clinical routine is currently being developed (certification class 2a is ongoing).

The multicentre, epidemiological (population representative) long-term project "National Cohort Nicotine study" poses the question of the determinants of smoking behavior in the German population from a socio-economic , medical , pathophysiological as well as molecular genetic and epidemiological point of view over the long term - and has been funded by the German Research Foundation (DFG) since 2006 - from 2006 initially within the framework of the translationally oriented DFG priority program SPP1226 (Nicotine - Molecular and pathophysiological effects in CNS) coordinated by Georg Winterer, most recently from 2019 to probably 2031 within the framework of the Collaborative Research Center SFB / TRR265: Loss and regaining of control in addiction disorders: courses , Mechanisms and interventions. As part of this project, too, an AI-supported app is being developed to predict the risk of the long-term course of addictive disorders in routine clinical practice.

Entrepreneurial activity

In the mid-1990s, Winterer worked as a senior study doctor (CNS) and consultant (phase 1 / phase 2 studies) at the clinical research organization Parexel , initially in Berlin and later in Washington DC. After returning to Germany, he founded Pharmaimage Biomarker Solutions GmbH. In the first few years, the company's business model consisted primarily of supporting the research-based pharmaceutical industry in Germany and the European Union with the implementation of drug studies (approval studies phase 1/2: first-in-man and first-in-patient studies) . In 2016, the subsidiary Pharmaimage Biomarker Solutions Inc. was founded in Cambridge (Kendall Square) near Boston (USA). In 2019, Winterer founded PI Health Solutions GmbH and PI Insure Solutions GmbH under the umbrella of the PI Solutions Group GmbH holding. PI Health Solutions GmbH is a developer of AI-supported diagnostic software for the risk prediction of the course of diseases (e.g. BioCog software). At the same time, the company provides logistical service for the implementation of studies in the health sector (excluding pharmaceuticals), e.g. B. currently in the context of the study "SARS-CoV-2: A dynamic nationwide representative study (Corona-BUND study) ", financed by the Federal Ministry of Health since June 2020 .

Publications

  • with Zacharias N, Musso F, Müller F, Lammers F, Saleh A, London M, de Boer P (2020): Ketamine effects on default mode network activity and vigilance: A randomized, placebo-controlled crossover simultaneous fMRI / EEG study . 9 Hum Brain Mapp. 2020 Jan; 41 (1): 107-119. doi: 10.1002 / hbm.24791.
  • with Lammers F, Mobascher A, Musso F, Shah NJ, Warbrick T, Zaborszky L (2015): Effect of the Nucleus basalis of Meynert on attention shows hemispheric asymmetry. Brain & Behav (in press). doi: 10.1002 / brb3.421.
  • with Reinthaler EM (2014): 16p11.2 European Consortium, Lerche H, Nürnberg P, Mefford H, Scheffer IE, Berkovic SF, Beckmann JS; EPICURE Consortium; EuroEPINOMICS Consortium, Sander T, Jacquemont S, Reymond A, Zimprich F, Neubauer BA (2014). 16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy. Hum Mol Genet 23: 6069-80
  • with Quednow, BB, Brinkmeyer J, Mobascher A, Nothnagel M, Musso F, founder G, Savary N, Petrovsky N, Frommann I, Lennertz L, Spreckelmeyer KN, Wienker TF, Dahmen N, Thuerauf N, Clepce M, Kiefer F, Majic T, Mössner R, Maier W, Gallinat J, Diaz-Lacava A, Toliat MR, Thiele H, Nürnberg P, Wagner M (2012): Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. PNAS 109: 6271-6
  • with Musso F, Brinkmeyer J, Ecker D, London MK, Thieme G, Warbrick T, Wittsack HJ, Saleh A, Greb W, de Boer P (2011): Ketamine effects on brain function - simultaneous fMRI / EEG during a visual oddball task. Neuroimage. 2011 Sep 15; 58 (2): 508-25. doi: 10.1016 / j.neuroimage.2011.06.045.
  • with Rolls ET, Loh M, Deco G (2008): Schizophrenia and computational models of dopamine modulation in the prefrontal cortex. Nature Reviews Neuroscience 9: 696-709
  • with Musso F, Konrad A,…. Sander T, Gallinat, J. (2007): Association of attentional network function and exon 5 variations of the CHRNA4 gene. Human Mol Genet 16: 2165-2174
  • with Klöppel B, Heinz A, Ziller M, Dufeu P, Schmidt LG, Herrmann WM (1998a): Quantitative EEG (QEEG) Predicts Relapse in Patients With Chronic Alcoholism and Points to a Frontally Pronounced Cerebral Disturbance. Psychiatry Res. 1998a Mar 20; 78 (1-2): 101-13. doi: 10.1016 / s0165-1781 (97) 00148-0.
  • with Ziller M, Klöppel B, Heinz A, Schmidt LG, Herrmann WM (1998b): Analysis of Quantitative EEG With Artificial Neural Networks and Discriminant Analysis - A Methodological Comparison. Neuropsychobiology. 1998b; 37 (1): 41-8. doi: 10.1159 / 00002647

Web links

Individual evidence

  1. ↑ Prof. Dr. med. Georg Winterer in 80331 Munich, specialist in neurology, psychiatry and psychotherapy - sanego. Retrieved July 14, 2020 .
  2. ↑ Susanne Donner: When memory fails after the operation. DER SPIEGEL, accessed on July 14, 2020 .
  3. ↑ a b c Wolf Blaum: Clinical Neurosciences. Retrieved July 14, 2020 .
  4. ↑ a b team. Retrieved July 14, 2020 .
  5. ↑ Andreas Heinz: Somato-psychosomatic development and therapy of chronic pain . Königshausen & Neumann, 2001, ISBN 978-3-8260-2004-9 .
  6. ↑ Georg Winterer, Richard Coppola, Michael F. Egan, Terry E. Goldberg, Daniel R. Weinberger: Functional and effective frontotemporal connectivity and genetic risk for schizophrenia . In: Biological Psychiatry . tape 54 , no. 11 , December 1, 2003, ISSN  0006-3223 , p. 1181-1192 , doi : 10.1016 / s0006-3223 (03) 00532-8 , PMID 14643085 .
  7. ↑ Johannes Gutenberg University Mainz: Mainz psychiatrist makes a pioneering contribution to the clarification of the schizophrenic brain dysfunction. Retrieved July 14, 2020 .
  8. ^ University of Düsseldorf: Prof. Dr. Georg Winterer appointed. Retrieved July 14, 2020 .
  9. ↑ Georg Winterer: Risk gene variants for nicotine dependence: a success story in neuropsychiatric genetics with possible applications to drug development . In: Pharmacogenomics . tape 11 , no. October 10 , 2010, ISSN  1744-8042 , p. 1353-1357 , doi : 10.2217 / pgs.10.144 , PMID 21047198 .
  10. ↑ Forschungszentrum Jülich - News - Epoch versus impulse models in the analysis of parametric fMRI studies. Retrieved July 14, 2020 .
  11. ^ A b Wolf Blaum: Clinical Neurosciences. Retrieved July 14, 2020 .
  12. ↑ a b c d CV Georg Winterer. In: PI Pharmaimage Solutions GmbH. PI Pharmaimage Solutions GmbH, February 1, 2017, accessed on July 14, 2020 .
  13. ↑ DFG priority program: Effects of nicotine in the central nervous system. Retrieved July 14, 2020 .
  14. ^ University of Düsseldorf: Effects of nicotine in the central nervous system. Retrieved July 14, 2020 .
  15. ^ University of Düsseldorf: Discovery of immunological abnormalities in the blood of patients with schizophrenia. Retrieved July 14, 2020 .
  16. ^ A b Norman Zacharias, Francesco Musso, Felix Müller, Florian Lammers, Andreas Saleh: Ketamine effects on default mode network activity and vigilance: A randomized, placebo-controlled crossover simultaneous fMRI / EEG study . In: Human Brain Mapping . tape 41 , no. 1 , 2020, ISSN  1097-0193 , p. 107–119 , doi : 10.1002 / hbm.24791 , PMID 31532029 , PMC 7268043 (free full text).
  17. ↑ G. Winterer, B. Klöppel, A. Heinz, M. Ziller, P. Dufeu: Quantitative EEG (QEEG) predicts relapse in patients with chronic alcoholism and points to a frontally pronounced cerebral disturbance . In: Psychiatry Research . tape 78 , no. 1-2 , March 20, 1998, ISSN  0165-1781 , pp. 101-113 , doi : 10.1016 / s0165-1781 (97) 00148-0 , PMID 9579706 .
  18. ^ G. Winterer, M. Ziller, B. Klöppel, A. Heinz, LG Schmidt: Analysis of quantitative EEG with artificial neural networks and discriminant analysis - a methodological comparison . In: Neuropsychobiology . tape 37 , no. 1 , 1998, ISSN  0302-282X , p. 41-48 , doi : 10.1159 / 000026475 , PMID 9438271 .
  19. ↑ Christian Eggers: Schizophrenia of childhood and adolescence . MWV, 2015, ISBN 978-3-95466-173-2 .
  20. ^ Edmund T. Rolls, Marco Loh, Gustavo Deco, Georg Winterer: Computational models of schizophrenia and dopamine modulation in the prefrontal cortex . In: Nature Reviews Neuroscience . tape 9 , no. 9 , September 2008, ISSN  1471-0048 , p. 696-709 , doi : 10.1038 / nrn2462 .
  21. ^ Biomarker Development for Postoperative Cognitive Impairment in the Elderly. In: Community Research and Development Information Service (CORDIS). European Commission, accessed July 14, 2020 .
  22. ↑ Program Summary. Retrieved July 14, 2020 .
  23. ↑ A. Mobascher, G. Winterer: Mechanisms of nicotine dependence . In: Pneumology . tape 62 , no. 9 , 2008, ISSN  0934-8387 , p. 553-561 , doi : 10.1055 / s-2008-1038159 .
  24. ^ Marcus Rothkirch: Team. Retrieved July 14, 2020 .
  25. ↑ Westdeutsche Zeitung: Düsseldorf researchers are looking for the smoking gene. Retrieved July 14, 2020 .
  26. ↑ PI Insure Solutions GmbH, Berlin - Health, Wellness & Fitness. Retrieved July 14, 2020 .
  27. ↑ Medical students wanted for Corona BUND study! July 6, 2020, accessed on July 14, 2020 .


personal data
SURNAME Winterer, Georg
BRIEF DESCRIPTION German entrepreneur, doctor and university lecturer
DATE OF BIRTH July 9, 1961
PLACE OF BIRTH Hausach