Gerhard Ehninger

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Gerhard Ehninger (born June 11, 1952 in Simmozheim ) is a German medic . From 1994 to 2018 he taught as a professor of internal medicine at the TU Dresden .

life and work

After graduating from the Hermann-Hesse-Gymnasium in Calw , Ehninger studied medicine at the Eberhard-Karls-Universität in Tübingen and obtained his doctorate. This was followed by the activity as a scientific assistant, the habilitation and the specialist certification as an internist. Then he worked there as a senior physician. The areas of hematology and oncology have been his main focus since 1978. Numerous clinical studies with accompanying pharmacological examinations for the first time described the pharmacokinetics and metabolism and the effectiveness of mitoxantrone in combination with cyclophosphamide in patients with breast cancer . Further work on the application in leukemia followed.

From 1986 he took over the management of the bone marrow transplant department at the Medical Clinic in Tübingen. Particular emphasis was placed on the transfer of blood stem cells from unrelated donors, avoiding the reaction of the transferred blood stem cells against patient tissue, the diagnosis and treatment of viral infections and the pharmacological properties of the drugs used. The first successful transfers of unrelated blood stem cells in Germany were carried out under his leadership.

The lack of unrelated donors in Germany prompted him, as secretary of the German Working Group for Bone Marrow and Blood Stem Cell Transplantation, to submit an application to the German Cancer Aid in 1987 to set up a donor database from among the blood donors . Ehninger then founded the German Bone Marrow Donor Center (DKMS) together with Peter Harf in 1991 . After one year, 100,000 volunteers were already registered. An important step towards the quick referral of donors was the complete typing of the relevant HLA characteristics. Today the DKMS is the world's largest single file with subsidiaries in Poland, England and the USA.

In 1994 he was appointed to the chair of internal medicine at the Technical University of Dresden . With the support of the German Cancer Aid, it was possible to improve the care of patients with cancer and to set up an interdisciplinary top center for the treatment of tumor diseases. The Mildred Scheel building is now one of the largest European transplant centers. Many new treatments have been developed there.

Numerous improvements in leukemia therapy have been achieved in national and international study groups. Today, Ehninger heads the Leukemia Study Alliance with over 50 clinics in Germany and the Czech Republic. Since 2005 he has been the spokesman for the DFG Collaborative Research Center 655 from cells to tissues.

In 2002 Ehninger founded the company Cellex and in 2011 together with Michael Bachmann the company GEMoab Monoclonals . In these companies, new drugs are developed from their scientific work on immunotherapy with new antibodies and genetically modified immune cells.

In 2018, Ehninger retired from the TU Dresden .

Other engagement

Ehninger has been involved in numerous committees such as the German Medical Association, the German Research Foundation and specialist societies. From 2004 to 2012 he was executive chairman of the German Society for Hematology and Oncology (DGHO). In 2010 he pointed out that the changes in the blood count in Claudia Pechstein were caused by congenital spheroid cell anemia and not by doping.

Ehninger took a stand against the demonstrations against the “Islamization of the West”, known as Pegida , and organized with the Dresden-Place to be! a festival with, among others, Herbert Grönemeyer , Keimzeit and Silly .

With numerous other events he advocates a cosmopolitan and tolerant Dresden. After the events in front of the Frauenkirche on October 3, 2016, he formed the alliance Dresden.Respekt under the motto “What unites us” with broad participation from citizens, associations, churches, cultural institutions, parties and representatives of the city.

Awards

  • Scholarship from the German National Academic Foundation 1971–1978
  • Prize for transfusion medicine of the blood donation services of the German Red Cross for its scientific achievements in the entire field of bone marrow and stem cell transplantation as well as cell therapy 2006
  • Erich Kästner Prize 2017
  • Honorary member of the German Society for Hematology and Oncology 2017

Web links

Individual evidence

  1. ↑ G. Ehninger, B. Proksch et al. a .: The pharmacokinetics and metabolism of mitoxantrone in man. In: Investigational New Drugs . Volume 3, Number 2, 1985, pp. 109-116, PMID 4019115 .
  2. ↑ G. Ehninger, U. Schuler u. a .: Pharmacokinetics and metabolism of mitoxantrone. A review. In: Clinical Pharmacokinetics . Volume 18, Number 5, May 1990, pp. 365-380, PMID 2185907 (review).
  3. ↑ G. Ehninger, KH Weible u. a .: Mitoxantrone and cyclophosphamide in patients with advanced breast cancer. In: Cancer Treatment Reports. Volume 68, Number 10, October 1984, pp. 1283-1284, PMID 6525600 .
  4. ^ AD Ho, T. Lipp et al. a .: Combination of mitoxantrone and etoposide in refractory acute myelogenous leukemia - an active and well-tolerated regimen. In: Journal of Clinical Oncology . Volume 6, Number 2, February 1988, pp. 213-217, doi : 10.1200 / JCO.1988.6.2.213 , PMID 3422260 .
  5. ↑ H. Einsele, G. Ehninger u. a .: Polymerase chain reaction to evaluate antiviral therapy for cytomegalovirus disease. In: The Lancet . Volume 338, Number 8776, November 1991, pp. 1170-1172, PMID 1682592 .
  6. ↑ U. Schuler, P. Waidelich u. a .: Pharmacokinetics and metabolism of cyclophosphamide administered after total body irradiation of bone marrow transplant recipients. In: European Journal of Clinical Pharmacology . Volume 40, Number 5, 1991, pp. 521-523, PMID 1884728 .
  7. ↑ G. Ehninger, R. Dopfer and a .: [Transplantation of bone marrow from unrelated donors in chronic myeloid leukemia]. In: German Medical Weekly . Volume 114, Number 25, June 1989, pp. 986-988, doi : 10.1055 / s-2008-1066705 , PMID 2661185 .
  8. ↑ G. Ehninger, CM Rutt u. a .: [Accumulation of German bone marrow donor data]. In: German Medical Weekly . Volume 119, Number 40, October 1994, pp. 1359-1364, doi : 10.1055 / s-2008-1058846 , PMID 7924941 (review).
  9. ^ Frankfurter Allgemeine Zeitung December 22, 1992, page N2 The national register for bone marrow donors is growing
  10. ↑ U. Schuler, C. Rutt u. a .: Approaches to managing volunteer marrow donor registry HLA data. Algorithms for directing donor center-initiated HLA-DR typing of selected donors. In: Reviews in Immunogenetics. Volume 2, Number 4, 2000, pp. 541-546, PMID 12361095 (review).
  11. ↑ DKMS. In: dkms.de. Retrieved October 14, 2018 .
  12. ^ University Hospital Carl Gustav Carus Dresden. In: uniklinikum-dresden.de. April 29, 2020, accessed April 29, 2020 .
  13. ↑ The cooperative study platform introduces itself. - SAL Study Alliance Leukemia. In: sal-aml.org. Retrieved October 14, 2018 .
  14. ↑ Collaborative Research Center 655 (funding period 2005-2017) - SFB 655. In: sfb655.de. Retrieved October 14, 2018 .
  15. ↑ C. Arndt, M. von Bonin u. a .: Redirection of T cells with a first fully humanized bispecific CD33-CD3 antibody efficiently eliminates AML blasts without harming hematopoietic stem cells. In: Leukemia. Volume 27, number 4, April 2013, pp. 964-967, doi : 10.1038 / leu.2013.18 , PMID 23325142 .
  16. ↑ M. Cartellieri, A. Feldmann a. a .: Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts. In: Blood Cancer Journal . Volume 6, number 8, 08 2016, p. E458, doi : 10.1038 / bcj.2016.61 , PMID 27518241 , PMC 5022178 (free full text).
  17. ↑ 3sat.online: With killer cells against cancer - First tests on 12 patients this year - 3sat.Mediathek. In: 3sat.de. April 20, 2017. Retrieved October 14, 2018 .
  18. ↑ Wolfgang Borgmann: Doping: spherical cell anemia with consequences. In: stuttgarter-zeitung.de. March 19, 2012, accessed October 14, 2018 .
  19. ↑ What unites us. Call to all Democrats, Demo: What unites us. Appeal to all democrats - Dresden.Respect. In: dresdenrespekt.de. June 13, 2017. Retrieved October 14, 2018 .
personal data
SURNAME Ehninger, Gerhard
BRIEF DESCRIPTION German medic
DATE OF BIRTH June 11, 1952
PLACE OF BIRTH Simmozheim