Louis Sokoloff

from Wikipedia, the free encyclopedia

Louis Sokoloff (born October 14, 1921 in Philadelphia , Pennsylvania , † July 30, 2015 in Washington, DC ) was an American neuroscientist . He is considered a pioneer in functional brain imaging .

Live and act

Sokoloff's father was a Jewish immigrant from Ukraine, his mother from Russia. Sokoloff studied at the University of Pennsylvania , including with Lewis Heilbrunn (1892-1959), who encouraged him to join a medical degree. After internship in psychiatry and military service, Sokoloff went to Seymour S. Kety at the University of Pennsylvania in 1949 . Using Kety's method of determining cerebral blood flow (CBF) by measuring the difference in arterio-venous concentration of nitrous oxide (N 2 O), Sokoloff was able to show that in hyperthyroidism, cerebral blood flow is not increased, while the basal metabolic rate is approximately is doubled. This led to the hypothesis that thyroid hormones , the protein biosynthesis stimulate. In the following years, Sokoloff was able to make significant contributions to the understanding of the function of the thyroid hormones. Kety's group conducted numerous studies to measure CBF during mental activity, sleep, and anesthesia, and under the influence of various drugs .

In 1951, Sokoloff moved with Kety to the National Institutes of Health (NIH) in Bethesda , Maryland , where Sokoloff eventually became head of the laboratory for brain metabolism. He held this position for the next 35 years.

Together with Kety, William M. Landau , Lewis Rowland and Walter Freygang , Sokoloff developed methods for the quantitative determination of a regional CBF using autoradiography in experimental animals. For the first time he was able to establish a connection between functional activity and regional blood flow. It was the first publication of functional brain imaging . Using 2-deoxy-D- 14 C - glucose could Sokoloff also represent the energy metabolism of the brain, almost completely based on glucose.

14 C was later replaced by 18 F and fluorodeoxyglucose was used, which in collaboration with Martin Reivich , David Kuhl , Alfred P. Wolf and Michael E. Phelps laid the foundation for positron emission tomography . Sokoloff's work has found its way from basic research to clinical routine.

Awards (selection)


Web links

Individual evidence

  1. Louis Sokoloff, NIH scientist who created technique to detect and treat major brain disorders, dies at 93
  2. ^ Past Officers and Members of the Council at the American Society for Neurochemistry (asneurochem.org); Retrieved April 22, 2012
  3. ^ Albert Lasker Clinical Medical Research Award 1981 Winners at the Lasker Foundation (laskerfoundation.org); Retrieved April 22, 2012
  4. Book of Members 1780 – present (PDF, 443 kB) of the American Academy of Arts and Sciences (amacad.org); Retrieved April 22, 2012
  5. ^ The Thomas W. Salmon Award and Lecture: Previous Lecturers at the New York Academy of Medicine (nyam.org); accessed on April 27, 2019
  6. ^ NAS Award in the Neurosciences from the National Academy of Sciences (nasonline.org); Retrieved April 22, 2012
  7. K. Harby: Seymour S. Kety, Louis Sokoloff to receive Hevesy Pioneer Award. In: Journal of nuclear medicine: official publication, Society of Nuclear Medicine. Volume 29, Number 5, May 1988, pp. 583-585, ISSN  0161-5505 . PMID 3286834 . (PDF, 587 kB)
  8. Dr. Louis Sokoloff at the American Philosophical Society (amphilsoc.org); Retrieved April 22, 2012